Jordan L. Meier, Ph.D.

Jordan L. Meier, Ph.D.
Senior Investigator
Head, Epigenetics and Metabolism Section

Epigenetic mechanisms—factors other than an individual’s DNA sequence—play a critical role in the regulation of gene expression and undergo routine disruption in cancer. Dr. Meier’s work focuses on the development of chemical approaches to study epigenetic signaling and its relationship to cellular metabolism. The goal of these studies is to better elucidate the underlying logic linking gene expression and metabolism, and apply this knowledge towards new approaches to cancer therapy, diagnosis, and chemoprevention.

Link to additional information about Dr. Meier's  research.

Areas of Expertise

1) chemistry, 2) biochemistry, 3) assay development, 4) metabolism, 5) epigenetics, 6) chemical proteomics

Contact Info

Jordan L. Meier, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 538, Room 245
Frederick, MD 21702-1201
Ph: 301-228-4889
jordan.meier@nih.gov

Metabolic Regulation of Epigenetic Signaling

Recent studies have shown that many enzymes active in epigenetic mechanisms of genomic regulation are sensitive to the metabolic state of the cell. A major aim of the lab is to understand the mechanisms by which metabolic perturbations influence genomic signaling mediated by chromatin modifying enzymes. Long term goals of this work include: 1) the discovery of biological mechanisms underlying oncometabolite-driven cancers, 2) the development of new diagnostics for cancers driven by metabolic mutations, and 3) the identification of small molecules which inhibit epigenetic modifications through metabolic disruption.

New Acetylation-Based Signaling Mechanisms

Acetyl-CoA links metabolism and signaling by mediating protein and nucleic acid modifications known as acetylations, whose modulation is an emerging paradigm in cancer treatment. A major focus of the laboratory is applying chemical approaches to discover and characterize new enzymatic and non-enzymatic acetylation mechanisms involved in fundamental biology and disease. By expanding the pharmacological map of acetylation-based signaling mechanisms in cancer, these studies aim to uncover new avenues for therapeutic development.

NIH Scientific Focus Areas:
Chemical Biology, Chromosome Biology, Molecular Pharmacology, RNA Biology
  1. Montgomery DC, Sorum AW, Meier JL.
    J. Am. Chem. Soc. 136: 8669-76, 2014. [ Journal Article ]
  2. Meier JL.
    ACS Chem. Biol. 8: 2607-2621, 2013. [ Journal Article ]
  3. Kang JS, Meier JL, Dervan PB.
    J. Am. Chem. Soc. 136: 3687-94, 2014. [ Journal Article ]
  4. Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB.
    J. Am. Chem. Soc. 134: 17814-22, 2012. [ Journal Article ]
  5. Meier JL, Mercer AC, Rivera H, Burkart MD.
    J. Am. Chem. Soc. 128: 12174-84, 2006. [ Journal Article ]

Dr. Meier received his undergraduate degree in chemistry from Creighton University in 2004, getting introduced to research as an National Science Foundation REU student. Following graduation he moved to the University of California-San Diego, performing graduate research in natural products biochemistry and proteomics under the mentorship of Professor Michael D. Burkart. After receiving his Ph.D. in chemistry in 2009, he moved to the California Institute of Technology. His research as an American Cancer Society postdoctoral fellow in the laboratory of Professor Peter B. Dervan focused on the development of high-throughput sequencing methods to analyze small molecule-DNA interactions. In 2013, Dr. Meier joined the NCI, where his research focuses on the development of synthetic probes to investigate metabolic and epigenetic signaling pathways in cancer.

Name Position
David Lee Bartee Ph.D. Postdoctoral Fellow (CRTA)
Keri M. Bryson Postbaccalaureate Fellow (CRTA)
Jared A. Grooms Postbaccalaureate Fellow (CRTA)
Yihang Jing Ph.D. Postdoctoral Fellow (Visiting)
Jose Montano Postbaccalaureate Fellow (CRTA)
Kellie Nance Ph.D. Postdoctoral Fellow (CRTA)
Minervo Perez Ph.D. Postdoctoral Fellow (CRTA)
Supuni Thalalla Gamage Ph.D. Postdoctoral Fellow (Visiting)
David Montgomery Postdoctoral Fellow 2013-2017

Current Position: Scientist II, Revolution Medicines, San Francisco CA

Allison Roberts Postbaccalaureate Fellow 2014-2015

PhD, UC-Berkeley, 2018, Current position: Scientist, Frontier Medicines, San Francisco CA

Thomas Zengeya Postdoctoral Fellow 2013-2017

Current position: Director of Manufacturing and Analytics at NeuBase Therapeutics, Pittsburgh PA

Rhushi Kulkarni Postdoctoral Fellow 2013-2018

Current position: Senior Scientist, Pfizer, La Jolla CA

Jonathan Shrimp Postdoctoral Fellow 2014-2019

Current Position: Senior Scientist, NCATS, Rockville MD

Jeff Lopez Postdoctoral Fellow 2017-2019

Current Position: Senior Scientist, Abzena, Bristol PA

Justin Thomas Postdoctoral Fellow 2017-2019

Current Position: Senior Scientist, Beam Therapeutics, Cambridge MA

Alexander Sorum Postbaccalaureate Fellow 2013-2015

Current position: Graduate student, Hsieh Wilson group, California Institute of Technology, Pasadena CA

Wilson Sinclair Postbaccalaureate Fellow 2015-2017

Current position: Graduate student, Bertozzi Group, Stanford University, Palo Alto CA

Julie Garlick Postbaccalaureate Fellow 2015-2016

Current position: Graduate student, Mapp group, University of Michigan, Ann Arbor MI

Abbey Thorpe Postbaccalaureate Fellow 2017-2018

Current position: Leidos Postbaccalaureate fellow, Frederick National Laboratory for Cancer Research, Frederick MD

Sarah Bergholtz Postbaccalaureate Fellow 2017-2019

Current position: Graduate student, University of Michigan, Ann Arbor MI

Chloe Briney Postbaccalaureate Fellow 2017-2019

Current position: MD/PhD student, University of Colorado, Denver CO

Fumarate Chemoproteomic Reactivity Database

To enable community efforts we have developed a web searchable database of FH-regulated cysteines identified by Kulkarni et al. (“A chemoproteomic portrait of the oncometabolite fumarate,” Nat. Chem Biol., 2019). It can be accessed at: https://ccr2.cancer.gov/resources/Cbl/Proteomics/Fumarate/