Craig J. Thomas, Ph.D.

Craig J. Thomas, Ph.D.
Adjunct Investigator

Craig Thomas serves as the group leader of chemistry technologies at the NIH Center for Advancing Translational Sciences (NCATS).  Dr. Thomas uses high-throughput technologies to make novel discoveries at the interface of chemistry and biology. His research interests include the production of novel screening libraries, the development of biologically active small molecules, the association of phenotype to pharmacology, the phenotypic screening of mechanistically annotated small molecule libraries, the development of novel drug combinations, and the progression of agents into advanced pre-clinical and clinical studies.

Link to additional information about Dr. Thomas's research.

Areas of Expertise

chemical biology, chemistry technologies

Contact Info

Craig J. Thomas, Ph.D.
Center for Cancer Research
National Cancer Institute
Building B, Room 3005
Rockville, MD 20850-3370
Ph: 301-217-4079
  1. Lionakis MS, Dunleavy K, Roschewski M, Widemann BC, Butman JA, Schmitz R, Yang Y, Cole DE, Melani C, Higham CS, Desai JV, Ceribelli M, Chen L, Thomas CJ, Little RF, Gea-Banacloche J, Bhaumik S, Stetler-Stevenson M, Pittaluga S, Jaffe ES, Heiss J, Lucas N, Steinberg SM, Staudt LM, Wilson WH.
    Cancer Cell. 31(6): 833-843.e5, 2017. [ Journal Article ]
  2. Gryder BE, Yohe ME, Chou HC, Zhang X, Marques J, Wachtel M, Schaefer B, Sen N, Song YK, Gualtieri A, Pomella S, Rota R, Cleveland A, Wen X, Sindiri S, Wei JS, Barr FG, Das S, Andresson T, Guha R, Lal-Nag M, Ferrer M, Shern JF, Zhao K, Thomas CJ, Khan J.
    Cancer Discov. [Epub ahead of print], 2017. [ Journal Article ]
  3. Mathews Griner LA, Zhang X, Guha R, McKnight C, Goldlust IS, Lal-Nag M, Wilson K, Michael S, Titus S, Shinn P, Thomas CJ, Ferrer M.
    Cell Death Dis. 7(12): e2492, 2016. [ Journal Article ]
  4. Li Y, Bouchlaka MN, Wolff J, Grindle KM, Lu L, Qian S, Zhong X, Pflum N, Jobin P, Kahl BS, Eickhoff JC, Wuerzberger-Davis SM, Miyamoto S, Thomas CJ, Yang DT, Capitini CM, Rui L.
    Oncogene. 35(48): 6223-6234, 2016. [ Journal Article ]
  5. Chen L, Wilson K, Goldlust I, Mott BT, Eastman R, Davis MI, Zhang X, McKnight C, Klumpp-Thomas C, Shinn P, Simmons J, Gormally M, Michael S, Thomas CJ, Ferrer M, Guha R.
    Sci Rep. 6: 37741, 2016. [ Journal Article ]

Craig Thomas received his B.S. from the University of Indianapolis in 1995 and his Ph.D. from Syracuse University in 2000. He then completed postdoctoral work in the laboratories of Sidney Hecht, where he earned a fellowship through the American Cancer Society. In 2003, Thomas joined NIH as director of the chemical biology core at the National Institute of Diabetes and Digestive and Kidney Diseases. In 2007, he moved to the NIH Chemical Genomics Center, which was supported by the National Human Genome Research Institute. The center now is supported by the NIH National Center for Advancing Translational Sciences (NCATS) and is called the NCATS Chemical Genomics Center. He is an adjunct member of the National Cancer Institute’s Chemical Biology Laboratory and an adjunct associate professor at the Georgetown University School of Medicine and the Temple University School of Medicine. Thomas is an editor of Current Protocols in Chemical Biology and a member of the SciFinder (Chemical Abstracts Service) advisory board. He has published more than 100 peer-reviewed manuscripts, is an inventor on more than 15 patents and has given numerous invited lectures.