Yinling Hu, Ph.D.

Yinling  Hu, Ph.D.
Senior Investigator
Head, Inflammation and Tumorigenesis Section

Dr. Hu's research focuses on understanding the physiological activities of IKKα in skin tumorigenesis and inflammation and in revealing the mechanisms by which IKKα regulates these functions by using genetic animal models, including Ikkα conditional knockout, Ikkα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.

Areas of Expertise
1) IKKα, 2) tumorigenesis 3) inflammation

Contact Info

Yinling Hu, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 567, Room 252
Frederick, MD 21702-1201
Ph: 301-846-1478
huy2@mail.nih.gov

The research interests of the Inflammation and Tumorigenesis Section are to understand the physiological activities of IKKα in skin tumorigenesis and inflammation and to reveal the mechanisms by which IKKα regulates these functions using genetic animal models, including Ikkα conditional knockout, Ikkα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.

Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Immunology, Molecular Biology and Biochemistry
  1. Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y.
    Proc Natl Acad Sci U S A. [Epub ahead of print], 2018. [ Journal Article ]
  2. Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y.
    Cell Host Microbe. 21(4): 478-493.e7, 2017. [ Journal Article ]
  3. Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y
    Cell Rep. 5(5): 1243-55, 2013. [ Journal Article ]
  4. Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y.
    Cancer Cell. 23(4): 527-40, 2013. [ Journal Article ]
  5. Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y.
    Cancer Cell. 14(3): 212-25, 2008. [ Journal Article ]

Dr. Hu received her undergraduate degree from the Chinese Academy of Medical Science (Beijing, China) and received her Ph.D from the University of Melbourne, (Melbourne, Australia). She was a postdoctoral fellow in Michael Karin's laboratory, University of California at San Diego from 1996 to 2001. Dr. Hu established her own laboratory in 2001 when she became an assistant professor at the Science Park Research Division, MD Anderson Cancer Center.  In 2008 she became a principal investigator in the Laboratory of Experimental Immunology, Cancer and Inflammation Program at NCI at Frederick.

Name Position
Sayantan Banerjee Ph.D. Postdoctoral Fellow (Visiting)
Zane Gray B.S. Postbaccalaureate Fellow
Weidong Li Ph.D. Research Collaborator
Gongping Shi Ph.D. Postdoctoral Fellow (Visiting)
Na-Young Song Ph.D. Postdoctoral Fellow (Visiting)
Jami Willette-Brown M.S. Research Microbiologist
Feng Zhu Ph.D. Research Fellow