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CCR-AMI Rodent List (CARL) - Model Details
Strain Information
Model Descriptor:
BDNF knockout
Common Gene Name:
BDNF
Official Gene Name:
Brain Derived Neurotrophic Factor
Mutation Type:
Null
Strain Background:
C57BL/6
Species:
Mouse
Phenotype:
Central and Peripheral nervous system defects including loss of sensory neurons in the inner ear. memory and learning defects. Heterozygous animals develop obesity and males show aggressive behavior. Homozygous mutants die at about 2-3 weeks.
References:
Pubmed ID:
10681461
Pubmed ID:
10611369
Additional Comments:
Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302 Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15239-44
Contact Information
NCI Investigator Name:
Lino Tessarollo
Phone Number:
301-846-1202
E-mail:
tessarol@mail.nih.gov
