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CCR-AMI Rodent List (CARL) - Model Details

Strain Information
   
Model Descriptor: WAP3-Int3sh
Common Gene Name: Notch4
Official Gene Name: Notch4
Mutation Type: Transgenic
Strain Background: FVB/N
Species: Mouse 
   
Phenotype: Females lactate and develop mammary tumors as well as tumors of organs that express WAP during pregnancy.
   
Additional Comments: The RAM23 region of the intracellular domain of human Notch4 has been deleted.
 
   
Contact Information
   
NCI Investigator Name: Robert Callahan
Phone Number: 301-496-9871
E-mail: callahro@mail.nih.gov