Our Science – O'Huigin Website
Colm S. O'Huigin, Ph.D.
A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity. To what extent are rapidly evolving pathogens (HIV, HCV) shaped to escape host immunity? Given the disparity of mutation rates compared with their host, can pathogens or commensals shape host immunity?
This page was last updated on 2/28/2013.