Our Science – Schmidt Website
Laura S. Schmidt, Ph.D.
Dr. Schmidt's research is focused on the identification of new renal cancer susceptibility genes through the study of families with inherited renal cell carcinoma. She was part of the NCI research teams that cloned the VHL tumor suppressor gene, identified germline c-MET proto-oncogene mutations in patients with hereditary papillary renal carcinoma type I, and recently identified mutations in a novel gene, BHD, that predispose to increased renal neoplasia in the Birt-Hogg-Dube' syndrome. Currently she is studying the Birt-Hogg-Dube' (BHD) protein, encoded by the BHD gene, to determine how the mutant protein contributes to the development of renal tumors. Dr. Schmidt is participating in recruitment of new renal cancer families in order to perform genome-wide linkage analysis to identify new renal cancer-causing genes. She is involved in the development and phenotype evaluation of several mouse models of renal cancer including conditional knockout of the VHL gene and conditional knockout of the BHD gene.
This page was last updated on 3/5/2013.