Our Science – Singh Website
Shree Ram Singh, Ph.D.
1998- Guest Scientist -Johann Wolfgang Goethe University, Frankfurt, Germany
2001-UNESCO-BAC Fellow Johann Wolfgang Goethe University, Frankfurt, Germany
2002-2003 - Postdoctoral Fellow, University of Haifa, Israel
2003-2008 -Postdoctoral Fellow, NCI-Frederick
2008-2011- Research Fellow, NCI-Frederick
Since 2011, Staff Scientist, Mouse Cancer Genetics Program at NCI-Frederick
Stem cells have the inherent abilities to self-renew and to differentiate into several specialized cell types as well as control the maintenance of our tissues and organs. Failure of such maintenance results in several degenerative diseases and cancer. Stem cells have recently attracted significant attention mainly because of their potential medical benefits in the fields of therapeutic cloning and regenerative medicine.
Our current research directed toward understanding the molecular genetic mechanism by which stem cells regulate tissues homeostasis, regeneration, and tumorigenesis. We are utilizing Drosophila and mouse models to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways regulate stem cell behavior and tumor formation. The knowledge gained from stem cells regulation in Drosophila and mouse models will provide a basis to understand how human adult stem cells response during normal and pathological conditions.
This page was last updated on 11/21/2013.