Our Science – Lautenberger Website
James A. Lautenberger, Ph.D.
My research involves discovering associations between human genes and disease outcomes. I recently have participated in the analysis of genome-wide association studies (GWAS) for AIDS and nasopharyngeal carcinoma (NPC) in the NCI Laboratory of Human Diversity (LGD). The LGD AIDS GWAS has detected a novel association between several SNPs in the PARD3B gene on chromosome 2 and the rate of progression to AIDS-defining clinical conditions. A plausible role for PARD3B in HIV/AIDS biology exists since the PARD3B product has been shown to bind several SMAD proteins including SMAD3 and SMAD4 that are associated with tat-mediated transcription of the HIV-1 LTR. A paper describing this association has recently been accepted for publication (Troyer et al., J. Inf. Dis., in press). In addition to the PARD3B association, several SNPs near the CCR5 gene on chromosome 3 were found to be significantly associated with infection susceptibility reconfirming this previously described association. In performing these analyses I have developed expertise in the management of large clinical data sets, the management of large sets of genotypic data, and the detection of genotype-phenotype associations with categorical and survival analysis techniques.
This page was last updated on 2/27/2013.