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Sergei Pletnev, Ph.D.

Portait Photo of Sergei Pletnev
Macromolecular Crystallography Laboratory
Synchrotron Radiation Research Section
Staff Scientist (Contr)
Center for Cancer Research
National Cancer Institute
Argonne National Laboratory
Building 202, Room E-179
9700 S. Cass Avenue
Argonne, IL 60439


Dr. Pletnev received his Ph.D. in 1997 from the Shubnikov Institute for Crystallography, Russian Academy of Sciences, under the supervision of Professor Emil Harutyunyan. He received his postdoctoral training in the laboratory of Professor Michael Rossmann at Purdue University working, among the others, on the projects that revealed the structures of Sindbis and Dengue viruses. In 2001, Dr. Pletnev joined the Macromolecular Crystallography Laboratory.


Dr. Pletnev's current research focuses on structural studies of fluorescent proteins (FPs), a class of natural and bio-engineered proteins that are used as non-invasive fluorescent biomarkers and biosensors. The primary application of FPs is in vivo measurements of certain physical and chemical parameters of cells or particular cellular compartments (e.g., pH, concentration of specific ions), monitoring of gene expression, protein labeling, and tissue visualization. Dr. Pletnev's structural studies are aimed at improving the physical and chemical characteristics of FPs that are important for their successful practical application: brightness, photo- and pH stability, ion sensitivity, phototoxicity, photoswitchability, time-resolved properties, etc.

Dr. Pletnev conducts his research in collaboration with two leading institutions in the field of fluorescent proteins: the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences and Albert-Einstein College of Medicine.

This page was last updated on 2/26/2013.