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Sankaran Subramanian, Ph.D.

Portait Photo of Sankaran Subramanian
Radiation Biology Branch
Biophysical Spectroscopy Section
Staff Scientist
Center for Cancer Research
National Cancer Institute
Building 10 - Magnuson CC, Room B3B69
Bethesda, MD 20892
Phone:  
301-443-6490
Fax:  
301-402-2238
E-Mail:  
subu@helix.nih.gov

Biography

Sankaran Subramanian did his BSc and MSc degrees from Kerala University, India after which he joined the Bhabha Atomic Research Center (BARC) as Scientist in 1963. He got a scholarship (1966) for PhD at the University of Leicester, under the supervision of Martyn Symons. Subsequently, he worked for a year as post-doc at Leicester, and then as Research Fellow with Max Rogers at Michigan State University. After returning to India, he was Assistant Professor of Chemistry (1971-79) and Professor (1979-97 ), Department of Chemistry, at the Indian Institute of Technology, Madras (Chennai), India. Since1998, he has been working as Scientist at National Cancer Institute, NIH, Bethesda.

Subramanian's researches encompass Electron Spin and Nuclear Magnetic Resonance Spectroscopy and Imaging (EPR, NMR, EPRI & MRI) as well as quantum chemical studies on molecular structure. He worked on the structure of short-lived free radicals and transition metal complexes using EPR and quantum mechanical calculations. He also worked on the NMR of paramagnetic crystals. He and his colleagues were involved in the development of non-empirical MO calculations, NDDO-MO calculations, and the theoretical evaluation of NMR chemical shifts and spin-spin coupling constants. As Alexander Humboldt Fellow at the University of Mainz he worked on NMR relaxation of polymers and the development instrumentation for double resonance for high resolution solid state NMR spectroscopy. He also studied the solution structure of small peptides and protein fragments using two-dimensional NMR spectroscopy and molecular modeling. He was involved in the preparation and structural investigation of several synthetic high Tc superconducting compounds. He has mentored 21 Ph. D. students, co-authored a book on FT-NMR (Modern Techniques in High Resolution FT-NMR, Springer-verlag, NY 1987), published more than 160 papers, several reviews, and book chapters on Magnetic Resonance Spectroscopy, instrumentation and Imaging.

Research

Dr. Subramanian along with his colleagues is involved in the development of both time-domain and continuous wave (Pulsed Fourier Transform and CW) Electron Paramagnetic Resonance imaging of small animals with the aim of mapping oxygen distribution in animal models of cancer. This has led to non-invasive quantitative estimates of tumor hypoxia and monitoring of cancer tissue oxygenation. Coupled with MRI co-registration in vivo EPR imaging has led to a better understanding of tumor physiology and the effect of tumor drugs. He has eight patents to his credit. Fast time-domain and CW in vivo EPR and MRI functional imaging and its applications in cancer research are some of themes being pursued by the Biophysical Spectroscopy and Imaging Section of the Radiation Biology Branch, CCR, NCI, NIH.

This page was last updated on 3/31/2014.