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Connie L. Sommers, Ph.D.

Portait Photo of Connie Sommers
Laboratory of Cellular and Molecular Biology
Staff Scientist
Center for Cancer Research
National Cancer Institute
Bldg. 37, Rm. 2066
Bethesda, MD 20892-4256
Phone:  
301-496-8910
Fax:  
301-496-8479
E-Mail:  
sommersc@helix.nih.gov

Biography

Dr. Sommers received her Ph.D. degree from Georgetown University in 1993. She was the first to describe vimentin expression in breast cancer cells and described epithelial-to-mesenchymal transition in breast cancer. During her post-doctoral studies in Dr. Paul Love's laboratory in NICHD, she studied the role of tyrosine kinases in thymocyte development and developed expertise in generating transgenic and knockout mouse models (1994-1999). Since 1999, Dr. Sommers has been a Staff Scientist in Dr. Lawrence Samelson's lab with expertise in using mouse models to study T cell signaling pathways and lymphoproliferative disease.

Research

Our research focuses on deciphering the role of LAT in T cell development and T cell function using transgenic mouse models. In particular, a knock-in mutant of LAT (LATY136F) has revealed an important role for LAT in immune homeostasis since these knock-in mice have a severe lymphoproliferative disease. Our research also investigates the roles of other T cell signal transduction intermediates in the development and function of LATY136F and normal T cells. In addition we have recently been investigating the role of microRNAs in lymphoproliferative disease.

This page was last updated on 4/15/2014.