Our Science – Gardner Website
Kevin Gardner, M.D., Ph.D.
Our laboratory studies chromatin-based mechanisms of transcriptional control and how they govern gene expression programs in response to extrinsic and intrinsic environmental clues during health and disease. To accomplish this, the lab has focused on the mechanisms of gene regulatory control by transcriptional co-regulators. Generically these are transcriptional regulators that do not bind to DNA specifically but are recruited to gene regulatory regions by DNA-specific transcription factors to change or modify chromatin accessibility to facilitate or prevent the assembly of the basal transcriptional machinery that controls gene expression. Thus a major research focus in the lab is the role of epigenetic modifications in the control of gene expression and cellular phenotypic change. Our group studies several different cellular systems that are relevant to lymphoid and epithelial malignancies. The most recent concentration has been on gene regulatory processes important in the evolution of leukemia and the mechanisms of breast cancer tumor initiation and progression. Using these approaches, in combination with my perspective as a pathologist, we have assembled a research program that incorporates molecular, biochemical, and cell biological methodology with genome-wide bioinformatics and computational technology to assemble a research portfolio that we are leveraging, through multi-disciplinary translational applications, to define molecular links between race, lifestyle, the environment, and disease.
Current work in the laboratory falls into two major areas of basic research, each with translational application to diagnosing, treating, and understanding human malignancies: 1.) The Mechanism of Transcriptional Control by p300-ELL complexes. 2.) Transcriptional regulation by BRCA1-associated coregulator complexes.
This page was last updated on 11/7/2013.