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Dennis D. Hickstein, M.D.

Portait Photo of Dennis Hickstein
Experimental Transplantation and Immunology Branch
Head, Molecular Oncology and Gene Transfer Section
Senior Investigator
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield CRC, Room 3-3142
Bethesda, MD 20892-1203
Phone:  
301-594-1718
Fax:  
301-402-5054
E-Mail:  
hicksted@mail.nih.gov

Biography

Dr. Hickstein was recruited to the National Cancer Institute in 2000 from the University of Washington School of Medicine where he was an Associate Professor of Medicine in the Division of Hematology. Dr. Hickstein is currently the head of Molecular Oncology and Gene Transfer in the Experimental Transplantation and Immunology Branch of the National Cancer Institute. His clinical interests are in hematopoietic stem cell transplantation and gene transfer in to hematopoietic stem cells for the correction of the genetic immunodeficiency diseases LAD-1, GATA2 deficiency, and DOCK8 deficiency.

Research

Molecular Oncology and Gene Transfer

The research in our laboratory involves two areas of investigations. The first area of study focuses on the correction of the disease phenotype in three genetic immunodeficiency diseases-leukocyte adhesion deficiency type 1, GATA2 deficiency, and DOCK8 deficiency-using two approaches: allogeneic hematopoietic stem cell transplantation and gene transfer into hematopoietic stem cells. These studies are designed to achieve long-term correction of hematopoietic stem cells. In the second area of study, we are developing zebrafish models of human blood diseases, particularly a zebrafish model of GATA2 deficiency.

This page was last updated on 12/9/2013.