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Michael Bustin, Ph.D.

Portait Photo of Michael Bustin
Laboratory of Metabolism
Head, Protein Section
Senior Investigator
Center for Cancer Research
National Cancer Institute
Building 37, Room 3122
Bethesda, MD 20892-4255
Phone:  
301-496-5234
Fax:  
301-496-8419
E-Mail:  
bustin@helix.nih.gov

Biography

Michael Bustin received his Ph.D. from University at California, Berkeley and did postdoctoral work in the area of protein chemistry, in the laboratory of Drs. S. Moore and W. Stein at the Rockefeller University in New York, and in the area of immunochemistry at the Weizmann Institute of Science, Israel, where he produced antibodies to histones and pioneered their use for studies on chromatin structure and function. His research interests center on the role of chromosomal proteins in chromatin function, gene expression, development and cancer.

Research

Chromosomal Proteins and Chromatin Function

Precise and specific interactions between chromosomal proteins and the chromatin fiber play a key role in epigenetic regulation, transcription, replication and DNA repair and therefore affect the orderly progression of biological processes such as development and differentiation. Numerous diseases, including cancer, are associated with changes in chromatin structure and function. The research aim of the Protein Section is to study the molecular mechanisms whereby nuclear proteins affect the structure and function of chromatin and play a role in establishing the cellular phenotype. The focus is on architectural proteins such as HMGN, the linker histone H1 and additional members of the high mobility group (HMG) protein family, which have been shown to affect the structure and function of chromatin and play a role in development and disease.

The laboratory employs a multidisciplinary approach, including analysis of transgenic and knock-out mice, and methodologies used in molecular biology, biochemistry, cell biology and immunochemistry, to study:

1. Molecular mechanisms whereby chromosomal proteins modulate gene expression from chromatin.

2. Mechanisms whereby HMGN chromosomal proteins affect the cellular phenotype and modulate embryonic differentiation.

3. The role of HMGN chromosomal proteins in modulating DNA repair processes.

4. The role of architectural chromatin binding proteins in epigenetic regulation.

5. Global organization of architectural proteins in the nucleus and in chromatin and their role in chromatin dynamics.

For more details about our research program, list of publications, and representative results please visit the Bustin Laboratory Web site.

This page was last updated on 6/7/2013.