Our Science – Winkler Website
Cheryl Ann Winkler, Ph.D.
The major objectives of my laboratory group are to identify host factors that contribute to infectious and other complex diseases with the goals of identifying targets for therapeutic intervention, improving diagnosis, and informing interpretation of clinical and vaccine trials.
1. Identification of genetic factors in kidney disease
Focal segmental glomerulosclerosis (FSGS) is the leading cause of primary nephrotic syndrome in adults and the leading cause of end-stage renal disease in children. HIV-associated nephropathy (HIVAN) occurs in 10% of untreated HIV persons of African descent but is rarely observed in non-Africans. Together with Dr. Jeffrey Kopp, NIDDK, we have accrued over 1200 FSGS and HIVAN cases and normal and hypernormal controls. We are also participating in the Family Investigation of Nephropathy and Diabetes (FIND) consortium, with the goal of discovering genetic risk factors for diabetic nephropathy and end stage renal disease. Dr. Winkler led the team that identified MYH9 as a major susceptibility gene for common etiologies of chronic and end stage kidney disease in 2008.
2. Identification of genetic susceptibility/restriction factors to HIV-1, HCV and HBV infection and disease progression
Host factors contribute to individual susceptibility to infection, clearance and pathogenesis of viral infections including HIV-1, HCV and HBV. We have recently focused on four major groups of genes for their role in viral infection and pathogenesis. These include genes involved in: 1) the innate immunity pathways that target HIV-1 or other viral pathogens; 2) cytokines that regulate immune response; 3) host factors involved in successful completion of the viral life cycle; and 4) chemokine receptors that provide portals for HIV-1 cell entry and chemokines that bind these receptors.
3. Genetic investigation of nasal pharyngeal carcinoma (NPC) and hepatocellular carcinoma (HCC)
NPC and HCC are multifactoral cancers that are caused by interactions among genetic, virologic and environmental factors. NPC and HCC are associated with dietary and environmental risk factors and chronic infection by Epstein-Barr Virus (EBV) or by Hepatitis B Virus, respectively. Both cancers have unusually high prevalence rates in southeast China, where the risk of exposure to dietary risk factors is extremely high. We are investigating the effects of host genetic factors and their interactions on NPC and HCC susceptibility in participants from Guangxi and Guangdong Province of Southern China.
4. Identify genetic factors contribute to the development of inhibitors to factor VIII
Antibodies (inhibitors) to Factor VIII inhibitor develop in approximately 30% of persons with hemophilia A and greatly increases the difficulty of managing hemophilia. We are participating in an international collaboration, HIGS (Hemophilia Genetics Inhibitor Study), to identify genes that contribute to the development of inhibitors in persons with hemophilia A. This study is using a combination of family and association studies to identify genetic and environmental risk factors and their interactions that may be risk predictors.
This page was last updated on 6/7/2013.