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Zheng-Gang Liu, Ph.D.

Portait Photo of Zheng-Gang Liu
Laboratory of Genitourinary Cancer Pathogenesis
Head, Molecular Mechanisms of Apoptosis Section
Senior Investigator
Center for Cancer Research
National Cancer Institute
Building 37, Room 1130
Bethesda, MD 20892
Phone:  
301-435-6351
Fax:  
301-402-1997
E-Mail:  
zgliu@box-z.nih.gov

Biography

Dr. Liu received both his bachelor's and master's degrees in biochemistry from Peking University, People's Republic of China. He completed his Ph.D. training in Dr. Larry Schwartz's laboratory at the University of Massachusetts and carried out his postdoctoral training in the laboratory of Dr. Michael Karin at the University of California, San Diego. He joined the former Department of Cancer and Cell Biology, Medicine Branch, DCS, in 1998 and became a senior investigator in 2005. His research interests have focused on the molecular mechanisms of apoptosis and necrosis and the role of cell death and inflammation in tumorigenesis.

Research

Tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a critical role in diverse cellular events, such as cell proliferation, differentiation and cell death. TNF is also involved in many types of diseases, including cancer. Inappropriate production of TNF plays a critical role in the pathogenesis of both acute and chronic inflammatory diseases, for instance septic shock, AIDS, and arthritis. The development of anti-TNFalpha therapy is arguably the most significant achievement in the treatment of autoimmune diseases such as rheumatoid arthritis and Crohn's disease. Opposing effects of TNF on cancer have been described: a high dose of TNF (acute inflammation) has anti-neoplastic effects, for example, direct cytotoxicity on certain types of cancer, while an endogenous low dose of TNF (chronic inflammation) promotes cancer development. Studies from many laboratories have demonstrated that the diverse TNF-mediated biological responses are achieved through activating multiple signaling pathways.

Although much information about TNF signaling has been obtained in recent years, many molecular aspects of TNF signaling and its role in inflammation and cancer development remain unknown. Therefore, uncovering the molecular mechanism of TNF signaling will not only shed new light on the physiological regulation of TNF function but also help us to understand its role in inflammation and cancer development. In addition, due to the importance of macrophage in mediating inflammatory response, including TNF production, and the proposed role of tumor-associated macrophage (TAM) in tumorigenesis, an understanding of monocyte/macrophage differentiation will help us to understand the mechanism of inflammation-mediated tumor development. In the last 4 years, we have made several significant contributions towards a better understanding of the molecular mechanism regulating TNF signaling and macrophage differentiation. In the next 4 years we will continue to investigate the regulation of TNF signaling, particularly the molecular mechanisms of TNF-induced cell death, and to explore the underlying mechanism of the promoting effect of inflammation on tumorigenesis as specified in the following two projects:

Project 1. Studying the Regulation of TNF-induced Cell Death and the Involvement of Key Cell Death Regulatory Proteins in Tumorigenesis

Aim 1: Investigating the regulation of TNF-induced apoptosis by the novel anti-apoptotic protein, ATIA, and its potential role in tumorigenesis.

a) Understanding the underlying mechanism of the anti-apoptotic effect of ATIA.

b) Demonstrating the importance of ATIA in tumorigenesis.

Aim 2: Identifying and studying novel players in TNF-induced necrosis and exploring the role of necrosis in tumorigenesis.

Project 2. Investigating the Mechanism(s) of the Promoting Effect of Inflammation in Tumorigenesis

Aim 1: Understanding the role of TRADD-mediated inflammation in tumorigenesis.

Aim 2: Studying the regulation of monocyte/macrophage differentiation and the role of tumor-associated macrophage in tumorigenesis.

a) Investigating the regulation of monocyte/macrophage differentiation.

b) Studying the role of tumor-associated macrophage in tumorigenesis.

This page was last updated on 3/31/2014.