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Alfred Singer, M.D.
Lymphocyte Development The differentiation of immature CD4+8+ (double positive, DP) thymocytes into mature T cells is the key event in T cell development as it gives rise to functional T cells and determines the mature T cell repertoire. Our research seeks to elucidate the molecular mechanism by which thymic selection generates an MHC-restricted T cell receptor repertoire that is coordinated with CD4 and CD8 coreceptor expression and appropriate T cell function.
This page was last updated on 9/13/2013.