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Alfred Singer, M.D.
Lymphocyte Development Development of all T cells takes place in the thymus and proceeds via an ordered sequence of developmental steps that is best described by changing expression patterns of surface CD4/CD8 coreceptor molecules. Each differentiation step is signaled by components of the T cell antigen receptor (TCR) complex. The differentiation of immature CD4+8+ (double positive, DP) thymocytes into mature T cells is the key event in T cell development as it gives rise to functional T cells and determines the mature T cell repertoire. DP thymocytes expressing TCR with appropriate specificities are
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