Our Science – Subramaniam Website
Sriram Subramaniam, Ph.D.
Three-Dimensional Electron Microscopy at Molecular Resolution
For a more detailed description of our research program, please visit our lab's Web site at http://electron.nci.nih.gov.
The long-term mission of our research program is to obtain an integrated, quantitative understanding of cells and viruses at molecular resolution. We take an interdisciplinary approach to this problem by combining novel technologies for three-dimensional (3D) imaging with computational and cell biological tools. Our research efforts are presently focused on three areas: (1) determination of the structure and mechanisms underlying neutralization and cellular entry of HIV, (2) the development of automated, high-throughput workflows for structure determination of small, dynamic molecular complexes, and (3) the development of novel technologies for 3D imaging of cells and tissues, with particular emphasis on methods for understanding and diagnosing structural signatures of signal transduction and disease progression.
This page was last updated on 1/9/2014.