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Kenneth H. Kraemer, M.D.

Portait Photo of Kenneth Kraemer
Dermatology Branch
Senior Investigator
Center for Cancer Research
National Cancer Institute
Building 37, Room 4002
Bethesda, MD 20892


Dr. Kraemer received his M.D. from Tufts Medical School and is board certified in dermatology and internal medicine. He has a longstanding interest in human cancer-prone genetic diseases and DNA repair. His studies focus on molecular, cellular, and clinical features of diseases including xeroderma pigmentosum and familial melanoma. He is a member of the American Society for Clinical Investigation and has received awards from the Society for Investigative Dermatology and the U.S. Public Health Service.


DNA Repair in Human Cancer-Prone Genetic Diseases

We are investigating the role of DNA repair in prevention of cancer and in human development. The
approach involves integrated clinical, molecular, and translational investigations of disorders with
defective DNA repair. Current studies are focusing on two rare genetic diseases: xeroderma
pigmentosum (XP) a cancer prone genetic disease with cellular hypersensitivity to ultraviolet radiation
(UV) and defective DNA repair and trichothiodystrophy (TTD) a disorder with developmental
abnormalities and defects in some of the same genes as XP without increased cancer risk. The long
term goals are to: 1) define the molecular defects in these diseases, 2) characterize their clinical
abnormalities and extent of phenotypic heterogeneity, 3) correlate the molecular defects with clinical
abnormalities, 4) assess the altered molecular function, 5) identify and characterize the underlying
mechanisms (pathophysiology) and how they lead to clinical disease and 6) influence these processes
by exploring methods of cancer prevention

Collaborators on our research include Margaret Tucker, GEB, DCEG, NCI, Brian Brooks, NEI, Carmen Brewer NIDCD

This page was last updated on 1/27/2014.