Our Science – Tessarollo Website
Lino Tessarollo, Ph.D.
Neurotrophins are a highly homologous family of secreted growth factors that have been extensively studied for their roles in the proliferation, survival, and differentiation of various cell populations in the mammalian nervous system. Each neurotrophin interacts with the p75 receptor and a specific member of the trk tyrosine kinase receptor family. Trk receptors, in addition to the tyrosine kinase isoforms, include receptors which lack kinase activity.
Over the last two decades many laboratories have contributed to the dissection of signaling pathways and the biological responses activated by neurotrophins in a variety of cell types. Most of this information was generated with the use of in vitro systems. Thus, many of these activities were caused by pharmacological rather than physiological activation of neurotrophin signaling. My laboratory is using the mouse as a genetically amenable in vivo tool to address some of the many still unresolved issues in neurotrophin biology. Specifically, we are interested in the role of neurotrophins in the mature nervous system and in non-neuronal organs such as the immune system. Furthermore, we are interested in the contribution of specific receptor isoforms and signaling pathways in mediating defined neurotrophin activities. In this respect we have generated a variety of mouse models that have helped us to dissect specific roles of neurotrophins in mouse development.
In addition, other recent accomplishments of our laboratory include the identification of proteins that interact with a phylogenetically conserved intracellular domain of truncated TrkC receptors. Thus, our finding may provide one of the long sought direct link between neurotrophins and signaling of truncated Trk receptors.
The study of neurotrophins functions not only in the mature nervous system but also in non-neuronal tissues should contribute to our understanding of the complex nature of ligand-receptor family interactions in the maintenance of higher organisms, and may lead to a better understanding of pharmacological neurotrophin activities in vivo.
This page was last updated on 2/27/2013.