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Kylie J. Walters, Ph.D.

Portait Photo of Kylie Walters
Structural Biophysics Laboratory
Head, Protein Processing Section
Senior Investigator
Center for Cancer Research
National Cancer Institute
Building 538, Room 140B
Frederick, MD 21702


Dr. Walters obtained her Ph.D. in Biophysics from Harvard University, where she used NMR spectroscopy to study protein structure and dynamics in Dr. Gerhard Wagner's laboratory. As an American Cancer Society Postdoctoral Fellow with Dr. Peter Howley in the Pathology Department at Harvard Medical School, she studied the ubiquitin signaling pathway. In 2002, she joined the University of Minnesota as an Assistant Professor and was promoted to Associate Professor with tenure in 2008. During this time, her lab used NMR spectroscopy to study ubiquitin signaling for degradation by proteasome. She was an American Cancer Society Research Scholar from 2007-2011 and in 2013, joined the Structural Biophysics Laboratory at NCI.


Projects in the Walters lab focus on how proteins are removed from cells. We are interested in how misfolded protein substrates are recognized and ubiquitinated by cellular surveillance systems and how ubiquitinated substrates are identified and processed by proteasome. We use a variety of biophysical techniques, our most powerful of which is NMR spectroscopy, to help develop a mechanistic understanding of how proteasome recognizes and processes its substrates. Our long-term goal is the manipulation of this process for proteins of interest, including oncoproteins and tumor suppressors.

This page was last updated on 6/10/2014.