Our Science – Kelly Website
Alexander E. Kelly, Ph.D.
As a postdoctoral fellow in the laboratory of Hironori Funabiki at the Rockefeller University, his work focused on the mechanism of activation of Aurora B kinase, a major cancer therapy target that orchestrates many aspects of mitosis. These studies led to the discovery of the non-transcriptional role of histone modification in the spatial control of chromosome segregation. He joined the Laboratory of Biochemistry & Molecular Biology in 2012.
The Kelly lab investigates the mechanisms eukaryotic cells use to ensure the faithful segregation of chromosomes, with a focus on the roles of post-translational modification of chromatin and kinetochore components during mitosis. A major research interest is the mechanism by which mitotic proteins 'sense' and correct improper microtubule-kinetochore attachments. These errors can give rise to aneuploidy and genome instability, both hallmarks of cancer cells. In addition, the lab studies the roles of mitotic histone modification and modifying enzymes in centromere formation and genome stability. Efforts are underway to identify new mitotic modifications of centromere and kinetochore components and the enzymes that place and remove them. The lab uses a combination of biochemistry, human cell culture and transcriptionally silent Xenopus egg extracts to understand how chemical signals at the kinetochore and centromere ensure high-fidelity chromosome segregation.
This page was last updated on 9/10/2013.