Our Science – Tofilon Website
Philip Tofilon, Ph.D.
Dr. Tofilon's research is aimed at understanding the molecular determinants of cellular radiosensitivity with the ultimate goal of developing target based radiosensitizing agents. An ongoing project involves radiation-induced gene expression, which has been generally considered to be the result of modifications in transcription. However, our recent studies revealed that radiation induces changes in gene expression not by modulating transcription, but through regulating the translation of existing mRNAs. Studies are presently aimed at understanding the mechanisms mediating the radiation-induced translational control of gene expression and whether this process provides a source of targets for tumor specific radiosensitization. An additional project focuses on the radiobiology of glioblastomas (GBMs) specifically addressing the influence of the brain microenvironment. These studies involve the use of GBM stem-like cells isolated from human surgical specimens grown in vitro and as intracranial xenografts.
This page was last updated on 4/9/2013.