Our Science – Aguda Website
Baltazar D. Aguda, Ph.D.
At the Neuro-Oncology Branch of the CCR/NCI, Dr. Aguda is developing network models involving genes, transcription factors and microRNAs associated with gliomagenesis. Current work is being focused on the interactions between myc and p53, two transcription factors - the first an oncogene and the second a tumor suppressor gene - that profoundly influence proliferative and differentiation pathways in cancer stem cells. How combinations of microRNAs work to finetune possible switching behaviors of the myc-p53 system is also a major question of interest. The ultimate goal is to generate hypotheses, amenable to experimental validation, on how to control and inhibit the propagation of glioma-initiating stem-like cells. His recent paper on the myc-p53 system has been featured in the Biophysical Journal (the paper is free online: Aguda BD et al., Qualitative Network Modeling of the Myc-p53 Control System of Cell Proliferation and Differentiation. Biophys. J. 101: 2082-91, 2011.)
Dr. Aguda also works in the field of network pharmacology, where his expertise in the analysis of complex biological networks and their control (with drug combinations) is yielding a very interesting algorithm.
This page was last updated on 2/26/2013.