Our Science – Uldrick Website

Thomas S. Uldrick, M.D.

HIV and AIDS Malignancy Branch Retroviral Disease Section Staff Clinician Center for Cancer Research National Cancer Institute Building 10, Room 6N106 Bethesda, MD 20892 Phone:   301-402-6296 Fax:   301-480-5955 E-Mail:   uldrickts@mail.nih.gov

Biography

Dr. Uldrick received his B.A. from the University of California at Berkeley, and his M.D. from the State University of New York, Downstate. He trained in internal medicine, hematology, and medical oncology at Columbia University. He was the recipient of a Patient-Oriented Research scholarship through Columbia University's NIH-sponsored Clinical and Translational Science Award, leading to an M.S. in biostatistics.

Prior to joining the HIV and AIDS Malignancy Branch, he was a Fogarty International Center Postdoctoral Trainee, collaborating with researchers in South Africa on issues related to the treatment of advanced AIDS-associated KS in resource-limited settings.

Research

Dr. Uldrick's major research interests are the natural history and management of virally associated malignancies that occur in the setting of HIV/AIDS and other immune disorders. Therapeutic studies focus on novel approaches to the treatment of several viral-associated malignancies using approaches that incorporate cytokine and growth factor manupulation and targeting of reservoirs of gamma-herpesvirus infected lymphoid cells using monoclonal antobodies or virus activated cytotoxic therapy.

Active projects include:

(1) Evaluation of the natural history of KSHV-associated disorders, including Kaposi sarcoma, KSHV-associated multicentric Castleman disease, primary effusion lymphoma, and a novel entity we described, KSHV-associated Inflammatory Cytokine Syndrome (KICS)

(2) Early-phase treatment studies in KSHV-associated malignancies employing immune modulating, anti-angiogenic and virus-activated cytotoxic therapies

(3) Evaluation of radiation-sparing approaches for HIV-associated primary CNS lymphoma, with an emphasis on long-term survival and neurocognitive functioning

(4) Evaluation of human genomic alterations and gut associated lymphoid tissue in patients with anal cancer

Current collaborators include:

Deborah Citrin, Radiation Oncology Branch, NCI
Nancy Hessol, UCSF
Frank Maldarelli, Drug Resistance Program, NCI
Anisa Mosam, University of KwaZulu-Natal, South Africa
Irini Sereti, Laboratory of Immunoregulation, NIAID
Giovanna Tosato, Laboratory of Cellular Oncology, NCI
Denise Whitby, Viral Oncology Section, NCI-Frederick
HIV+ Tumor Molecular Characterization Project, Office of Cancer Genomics, NCI

This page was last updated on 3/5/2013.