Our Science – Uldrick Website
Thomas S. Uldrick, M.D.
Dr. Uldrick's major research interests are the natural history and management of virally associated malignancies that occur in the setting of HIV/AIDS and other immune disorders. Therapeutic studies focus on novel approaches to the treatment of several viral-associated malignancies using approaches that incorporate cytokine and growth factor manupulation and targeting of reservoirs of gamma-herpesvirus infected lymphoid cells using monoclonal antobodies or virus activated cytotoxic therapy.
Active projects include:
(1) Evaluation of the natural history of KSHV-associated disorders, including Kaposi sarcoma, KSHV-associated multicentric Castleman disease, primary effusion lymphoma, and a novel entity we described, KSHV-associated Inflammatory Cytokine Syndrome (KICS)
(2) Early-phase treatment studies in KSHV-associated malignancies employing immune modulating, anti-angiogenic and virus-activated cytotoxic therapies
(3) Evaluation of radiation-sparing approaches for HIV-associated primary CNS lymphoma, with an emphasis on long-term survival and neurocognitive functioning
(4) Evaluation of human genomic alterations and gut associated lymphoid tissue in patients with anal cancer
Current collaborators include:
Deborah Citrin, Radiation Oncology Branch, NCI
Nancy Hessol, UCSF
Frank Maldarelli, Drug Resistance Program, NCI
Anisa Mosam, University of KwaZulu-Natal, South Africa
Irini Sereti, Laboratory of Immunoregulation, NIAID
Giovanna Tosato, Laboratory of Cellular Oncology, NCI
Denise Whitby, Viral Oncology Section, NCI-Frederick
HIV+ Tumor Molecular Characterization Project, Office of Cancer Genomics, NCI
This page was last updated on 7/10/2014.