Dr. Oberholtzer received his B.A. and Ph.D., both in biochemistry, from the University of Pennsylvania. After completing his M.D. at Jefferson Medical College, he returned to Penn for postodoctoral training, and then residency training in Anatomic Pathology and a Fellowship in Neuropathology. Dr. Oberholtzer was on the faculty of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine for fifteen years, most recently as Chief of the Division of Neuropathology and a Vice-Chair of the Department of Pathology and Laboratory Medicine. In addition to his clinical and administrative activities, he ran a NIH-funded molecular neuroscience laboratory in which he studied mechanisms of intrinsic frequency tuning in auditory hair cells, and signaling pathways involved in hair cell regeneration. Dr. Oberholtzer initially came to the National Cancer Institute as Associate Director for Training, a position in which he had overall responsibilities in both extramural and intramural training programs. He was appointed a Senior Clinician and Chief of the Laboratory of Pathology in 2008. Dr. Oberholtzer is a member of the American Society for Clinical Investigation, the American Association of University Pathologists (Pluto Club), and a Fellow of the College of Physicians of Philadelphia.