Our Science – Kedei Website

Noemi Kedei, M.D.

Laboratory of Cancer Biology and Genetics Molecular Mechanisms of Tumor Promotion Section Staff Scientist Center for Cancer Research National Cancer Institute Building 37, Room 4048 Bethesda, MD 20892 Phone:   301-496-2948 Fax:   301-496-8709 E-Mail:   kedein@mail.nih.gov

Biography

Biography
Dr. Kedei received her MD degree from University Medical School of Debrecen, Hungary. She worked as an assistant professor at the Department of Biochemistry and Molecular Biology, University Medical School of Debrecen. In 1999 Dr. Kedei joined the Molecular Mechanisms of Tumor Promotion Section, LCBG, as a postdoctoral fellow. Currently she continues to work with Dr. Peter M. Blumberg as a staff scientist.
Research

Research

Dr. Kedei's research focuses on understanding the factors contributing to the interaction of both synthetic ligands and natural products with protein kinase C (PKC), a validated anti-cancer target, and with other members of the PKC superfamily. A key question is to determine the mechanisms underlying the diverse biological responses to these ligands. Current efforts are directed at characterizing synthetic bryostatin derivatives termed bryologues. Bryostatin, while binding to and activating PKC, paradoxically antagonizes the responses of typical PKC ligands. Dr. Kedei seeks to define the structural features of bryostatin that determine this behavior and to trace the downstream mechanisms that account for the antagonism. Twin goals of the project are to develop structurally simplified bryostatin analogs and to identify those cancer subtypes in which the unique mechanism of bryostatin action would be predicted to have therapeutic benefit.

This page was last updated on 2/27/2013.