Our Science – Yu Website
Yan Lin Yu, Ph.D.
Dr. Yu's major research interest is focused on understanding molecular mechanisms in progression to the metastatic state in cancer. He has studied mechanisms underlying tumorigenesis in the hepatocellular carcinoma (HCC). Dr. Yu has generating transgenic mice inducibly expressing dominant negative fibroblast growth factor receptor (FGFR) mutants for studying the specific roles of receptor tyrosine kinases in cancer and normal development. He found that constitutive c-Met signaling through a non-autocrine mechanism promotes metastasis in a transgenic transplantation model, and determined that Ezrin and Six1 are critical regulators of metastasis in rhabdomyosarcoma.
This page was last updated on 7/11/2014.