Our Science – Davis Website
Jamaine S.C. Davis, Ph.D.
Field of Degree: Biochemistry & Molecular Biophysics
Degree Institution: University of Pennsylvania
Date Degree Granted: 08/2007
My overarching research goal is to couple systems-level cell biology with structural biology to establish models that accurately reflect essential biological processes. In particular, I am interested in understanding the broad role protein-protein interactions play in the control and regulation of chromatin dynamics. Protein-protein interactions are pivotal facilitators in the assembly and disassembly of essential macromolecular complexes, which function to regulate cellular homeostasis. The essential building blocks of these interactions are protein domains, which are central in cellular signaling networks and are often conserved throughout specific pathways. Two fundamental questions in the field are: how are the signals transmitted between distinct protein domains and what happens when this process is altered? My proposed research will address these and related questions beginning from the work I accomplished in the last three years. First, my work will investigate multi-domain chromatin-associated proteins that function in transcriptional regulation and DNA repair. The proposed research will determine the precise role these domains play in genome maintenance and homeostasis and how perturbing these interactions could make tumor cells more sensitive to chemo- and radiotherapies. Secondly, my work will investigate the genomic distribution of functional protein domains, which will help to understand key protein-protein interactions that regulate genes in normal and diseased states.
This page was last updated on 3/4/2013.