Our Science – Greer Website

Yoshimi Endo Greer, M.D., Ph.D.

Laboratory of Cellular and Molecular Biology Staff Scientist Center for Cancer Research National Cancer Institute Bldg.37, Room 2042 Bethesda, MD 20892 Phone:   301-496-9063 Fax:   301-496-8479 E-Mail:   GREERY@MAIL.NIH.GOV

Research

Dr. Greer's long term focus has been Wnt signaling pathway that is highly involved in variety types of human cancer as well as embryonic development.

Dr. Greer obtained MD, 1994, at Tohoku University School of Medicine, Sendai, Japan. She conducted residential training of internal medicine at Tohoku University Hospital and related local hospitals for 5 years.

In 1999, she obtained PhD with Renal Physiology at Graduate School of Tohoku University. Her work was about the effect of Angiotensin II receptor blocker on micro-hemodynamics in animal kidney model system. To extend her interest in renal physiology, she joined Dr. Josephine P. Briggs' lab in NIDDK as her first postdoc in 1998. She studied transcriptional regulatory mechanism of Cyclooxygenase-2.

In 2001, she joined Dr. Jeff Rubin's lab in NCI as her second post-doc, and investigated molecular mechanism of Wnt3a-dependent cell motility in mammalian cells.

In 2004, She joined Georgetown University Medical School as a Research Instructor (Junior Faculty), and studied transcriptional mechanism of VE-cadherin that is involved with retinoic acid-mediated trans-differentiation of breast cancer cells.

In 2006 summer, She came back to NCI as a Research Fellow. She discovered that Wnt-3a stimulates neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.

Since 2009 to present, she is a Staff Scientist in LCMB, NCI. Through active collaboration effort, she and her group investigated functional consequences of Wnt-induced Dishevelled2 Phosphorylation in Canonical and Non-Canonical Wnt Signaling. Furthermore, she identified atypical Protein Kinase C Iota as a factor required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled2.

Her recent discovery showed Casein Kinase 1 delta located to centrosome is required for Wnt-3a-dependent neurite outgrowth. Currently, she has been exploring further functional roles of CK1delta in other model systems.

This page was last updated on 2/26/2013.