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Yoshimi Endo Greer, M.D., Ph.D.

Portait Photo of Yoshimi Greer
Laboratory of Cellular and Molecular Biology
Staff Scientist
Center for Cancer Research
National Cancer Institute
Bldg.37, Room 2042
Bethesda, MD 20892
Phone:  
301-496-9063
Fax:  
301-496-8479
E-Mail:  
GREERY@MAIL.NIH.GOV

Biography

Dr. Greer obtained her M.D. in 1994 from Tohoku University School of Medicine in Sendai, Japan. Over the next 5 years, she completed her residency in internal medicine at Tohoku University Hospital and related local hospitals.

In 1999, Dr. Greer obtained a Ph.D. in renal physiology from the Graduate School of Tohoku University. Her research focused on the effect of the angiotensin II receptor blocker on micro-hemodynamics in an animal kidney model system. To extend her interest in renal physiology, Dr. Greer joined Dr. Josephine P. Briggs' lab at the National Institute of Diabetes and Digestive and Kidney Diseases as a postdoctoral fellow in 1998. In this role, she studied the transcriptional regulatory mechanism of cyclooxygenase-2.

In 2001, Dr. Greer joined Dr. Jeff Rubin's lab at the National Cancer Institute (NCI). During this second postdoctoral fellowship, she investigated the molecular mechanism of Wnt3a-dependent cell motility in mammalian cells.

In 2004, Dr. Greer joined Georgetown University Medical School as a research instructor (junior faculty). In this position, she studied the transcriptional mechanism of VE-cadherin that is involved with retinoic acid-mediated trans-differentiation of breast cancer cells.

In 2006, Dr. Greer returned to NCI as a research fellow. She discovered that Wnt-3a stimulates neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.

Since 2009, she has been a staff scientist in the Laboratory of Cellular and Molecular Biology.

Research

Dr. Greer's long-term focus has been the Wnt signaling pathway, which is highly involved in a variety of human cancers as well as in embryonic development.

Through an active collaboration, Dr. Greer investigated the functional consequences of Wnt-induced Dishevelled2 phosphorylation in canonical and non-canonical Wnt signaling. Furthermore, she identified atypical protein kinase C iota as a factor that is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled2.

Dr. Greer's most recent discovery showed that the casein kinase 1 delta (CK1delta) located at the centrosome is required for Wnt-3a-dependent neurite outgrowth.

Currently, Dr. Greer has been exploring further functional roles of CK1delta in other model systems.

This page was last updated on 4/9/2014.