Our Science – Zhao Website
Xue Zhi Zhao, Ph.D.
Through an extensive synthetic effort, I first examined 2,3-dihdroxybenzoylhydrazides and amides as a new classes of DKA mimetics. Then utilized methylene and oxomethylene bridges to form bicyclic variants of these 2,3-dihdroxybenzoylhydrazides and amides in which key metal-chelating heteroatoms are conformationally-constrained to coplanarity. These efforts have resulted in the discovery of structurally simple phthalimides that exhibit potent integrase inhibition at low nanomolar concentrations and display good antiviral potencies in HIV-1 infected cells.
This page was last updated on 3/5/2013.