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Our Science – Kobayashi Website

Hisataka Kobayashi, M.D., Ph.D.

Selected Publications

1)  Harada T, Sano K, Sato K, Watanabe R, Yu Z, Hanaoka H, Nakajima T, Choyke PL, Ptaszek M, Kobayashi H.
Activatable organic near-infrared fluorescent probes based on a bacteriochlorin platform: synthesis and multicolor in vivo imaging with a single excitation.
Bioconjug. Chem. 25: 362-9, 2014.
[Journal]
2)  Longmire MR, Ogawa M, Choyke PL, Kobayashi H.
Dendrimers as high relaxivity MR contrast agents.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 6: 155-62, 2014.
[Journal]
3)  Nakajima T, Sano K, Sato K, Watanabe R, Harada T, Hanaoka H, Choyke PL, Kobayashi H.
Fluorescence-lifetime molecular imaging can detect invisible peritoneal ovarian tumors in bloody ascites.
Cancer Sci. 105: 308-14, 2014.
[Journal]
4)  Turkbey B, Kobayashi H, Hoyt RF, Choyke PL, Nakajima T, Griffiths GL, Bernardo M, Rialon K, Fishman SJ, Sena LM.
Magnetic Resonance Lymphography of the Thoracic Duct after Interstitial Injection of Gadofosveset Trisodium: A Pilot Dosing Study in a Porcine Model.
Lymphat Res Biol. 2014.
[Journal]
5)  Sato K, Watanabe R, Hanaoka H, Harada T, Nakajima T, Kim I, Paik CH, Choyke PL, Kobayashi H.
Photoimmunotherapy: Comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor.
Mol Oncol. 2014.
[Journal]
6)  Sano K, Nakajima T, Choyke PL, Kobayashi H.
The effect of photoimmunotherapy followed by liposomal daunorubicin in a mixed tumor model: a demonstration of the super-enhanced permeability and retention effect after photoimmunotherapy.
Mol. Cancer Ther. 13: 426-32, 2014.
[Journal]
7)  Sano K, Nakajima T, Ali T, Bartlett DW, Wu AM, Kim I, Paik CH, Choyke PL, Kobayashi H.
Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging.
J Biomed Opt. 18: 101304, 2013.
[Journal]
8)  Ali T, Choyke PL, Kobayashi H.
Endoscopic molecular imaging of cancer.
Future Oncol. 9: 1501-13, 2013.
[Journal]
9)  Alexander VM, Choyke PL, Kobayashi H.
Fluorescent molecular imaging: technical progress and current preclinical and clinical applications in urogynecologic diseases.
Curr. Mol. Med. 13: 1568-78, 2013.
[Journal]
10)  Kobayashi H, Watanabe R, Choyke PL.
Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?.
Theranostics. 4: 81-9, 2013.
[Journal]
11)  Nakajima T, Sano K, Choyke PL, Kobayashi H.
Improving the efficacy of Photoimmunotherapy (PIT) using a cocktail of antibody conjugates in a multiple antigen tumor model.
Theranostics. 3: 357-65, 2013.
[Journal]
12)  Nakajima T, Turkbey B, Sano K, Sato K, Bernardo M, Hoyt RF, Choyke PL, Kobayashi H.
MR lymphangiography with intradermal gadofosveset and human serum albumin in mice and primates.
J Magn Reson Imaging. 2013.
[Journal]
13)  Rosenblum LT, Choyke PL, Kobayashi H.
Quantitative and specific molecular imaging of cancer with labeled engineered monoclonal antibody fragments.
Ther Deliv. 2: 345-58, 2011.
[Journal]
14)  Sano K, Mitsunaga M, Nakajima T, Choyke PL, Kobayashi H.
Acute Cytotoxic Effects of Photoimmunotherapy Assessed by 18F-FDG PET.
J. Nucl. Med. [Epub ahead of print], 2013.
[Journal]
15)  Nakajima T, Sano K, Choyke P, Kobayashi H.
Dual targeted photoimmunotherapy can synergistically enhance the therapeutic effects.
Theranostics. 3: 357-65, 2013.
[Journal]
16)  Sano K, Nakajima T, Choyke PL, Kobayashi H.
Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors.
ACS Nano. 7: 717-24, 2013.
[Journal]
17)  Mitsunaga M, Tajiri H, Choyke PL, Kobayashi H.
Monoclonal antibody-fluorescent probe conjugates for in vivo target-specific cancer imaging: toward clinical translation.
Ther Deliv. 4: 523-5, 2013.
[Journal]
18)  Kines RC, Kobayashi H, Choyke PL, Bernardo ML.
Optical imaging of HPV infection in a murine model.
Methods Mol. Biol. 961: 141-50, 2013.
[Journal]
19)  Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H.
Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes.
Bioconjug. Chem. [Epub ahead of print], 2013.
[Journal]
20)  Mitsunaga M, Kosaka N, Choyke PL, Young MR, Dextras CR, Saud SM, Colburn NH, Sakabe M, Nagano T, Asanuma D, Urano Y, Kobayashi H.
Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe.
Gut. [Epub ahead of print], 2012.
[Journal]
21)  Lim J, Turkbey B, Bernardo M, Bryant LH, Garzoni M, Pavan GM, Nakajima T, Choyke PL, Simanek EE, Kobayashi H.
Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics.
Bioconjug. Chem. 23: 2291-9, 2012.
[Journal]
22)  Alexander VM, Sano K, Yu Z, Nakajima T, Choyke PL, Ptaszek M, Kobayashi H.
Galactosyl Human Serum Albumin-NMP1 Conjugate: A Near Infrared (NIR)-Activatable Fluorescence Imaging Agent to Detect Peritoneal Ovarian Cancer Metastases.
Bioconjug. Chem. 23: 1671-9, 2012.
[Journal]
23)  Mitsunaga M, Nakajima T, Sano K, Kramer-Marek G, Choyke PL, Kobayashi H.
Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy.
BMC Cancer. 12: 345, 2012.
[Journal]
24)  Sano K, Mitsunaga M, Nakajima T, Choyke PL, Kobayashi H.
In vivo breast cancer characterization imaging using two monoclonal antibodies activatably labeled with near infrared fluorophores.
Breast Cancer Res. 14: R61, 2012.
[Journal]
25)  Kosaka N, Mitsunaga M, Choyke PL, Kobayashi H.
In vivo real-time lymphatic draining using quantum-dot optical imaging in mice.
Contrast Media Mol Imaging. 8: 96-100, 2012.
[Journal]
26)  Kosaka N, Bernardo M, Mitsunaga M, Choyke PL, Kobayashi H.
MR and optical imaging of early micrometastases in lymph nodes: triple labeling with nano-sized agents yielding distinct signals.
Contrast Media Mol Imaging. 7: 247-53, 2012.
[Journal]
27)  Mitsunaga M, Nakajima T, Sano K, Choyke PL, Kobayashi H.
Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate.
Bioconjug. Chem. 23: 604-9, 2012.
[Journal]
28)  Kobayashi H, Longmire MR, Choyke PL.
Polychromatic in vivo imaging of multiple targets using visible and near infrared light.
Adv. Drug Deliv. Rev. 2012.
[Journal]
29)  Nakajima T, Sano K, Mitsunaga M, Choyke PL, Kobayashi H.
Real-time Monitoring of In Vivo Acute Necrotic Cancer Cell Death Induced by Near Infrared Photoimmunotherapy Using Fluorescence Lifetime Imaging.
Cancer Res. 72: 4622-8, 2012.
[Journal]
30)  Kramer-Marek G, Longmire MR, Choyke PL, Kobayashi H.
Recent advances in optical cancer imaging of EGF receptors.
Curr. Med. Chem. 19: 4759-66, 2012.
[Journal]
31)  Kobayashi H, Choyke PL.
Recipe for a new imaging biomarker: carefully combine target, reagent, and technology.
Kidney Int. 81: 129-31, 2012.
[Journal]
32)  McCann TE, Kosaka N, Choyke PL, Kobayashi H.
The use of fluorescent proteins for developing cancer-specific target imaging probes.
Methods Mol. Biol. 872: 191-204, 2012.
[Journal]
33)  McCann TE, Kosaka N, Koide Y, Mitsunaga M, Choyke PL, Nagano T, Urano Y, Kobayashi H.
Activatable optical imaging with a silica-rhodamine based near infrared (SiR700) fluorophore: a comparison with cyanine based dyes.
Bioconjug. Chem. 22: 2531-8, 2011.
[Journal]
34)  Longmire MR, Ogawa M, Choyke PL, Kobayashi H.
Biologically Optimized Nanosized Molecules and Particles: More than Just Size.
Bioconjug Chem. 22: 993-1000, 2011.
[Journal]
35)  Mitsunaga M, Ogawa M, Kosaka N, Rosenblum LT, Choyke PL, Kobayashi H.
Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules.
Nat. Med. 17: 1685-91, 2011.
[Journal]
36)  Kojima C, Turkbey B, Ogawa M, Bernardo M, Regino CA, Bryant LH, Choyke PL, Kono K, Kobayashi H.
Dendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics.
Nanomedicine. 7: 1001-8, 2011.
[Journal]
37)  Mitsunaga M, Kosaka N, Kines RC, Roberts JN, Lowy DR, Schiller J, Ishihara Y, Hasegawa A, Choyke PL, Kobayashi H.
In vivo longitudinal imaging of experimental human papilloma virus infection in mice with a multi-color fluorescence mini-endoscopy system.
Cancer Prev Res. 4: 767-73, 2011.
[Journal]
38)  McCann TE, Kosaka N, Turkbey B, Mitsunaga M, Choyke PL, Kobayashi H.
Molecular imaging of tumor invasion and metastases: the role of MRI.
NMR Biomed. 24: 561-8, 2011.
[Journal]
39)  Kosaka N, Mitsunaga M, Longmire MR, Choyke PL, Kobayashi H.
Near infrared fluorescence-guided real-time endoscopic detection of peritoneal ovarian cancer nodules using intravenously injected indocyanine green.
Int J Cancer. 129: 1671-7, 2011.
[Journal]
40)  Urano Y, Sakabe M, Kosaka N, Ogawa M, Mitsunaga M, Asanuma D, Kamiya M, Young MR, Nagano T, Choyke PL, Kobayashi H.
Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe.
Sci Transl Med. 3: 110ra119, 2011.
[Journal]
41)  Kobayashi H, Longmire MR, Ogawa M, Choyke PL.
Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.
Chem Soc Rev. 40: 4626-48, 2011.
[Journal]
42)  Kobayashi H, Choyke PL.
Target-cancer-cell-specific activatable fluorescence imaging probes: rational design and in vivo applications.
Acc. Chem. Res. 44: 83-90, 2011.
[Journal]
43)  Nakajima T, Mitsunaga M, Bander NH, Heston WD, Choyke PL, Kobayashi H.
Targeted, Activatable, In Vivo Fluorescence Imaging of Prostate-Specific Membrane Antigen (PSMA) Positive Tumors Using the Quenched Humanized J591 Antibody-Indocyanine Green (ICG) Conjugate.
Bioconjug Chem. 22: 1700-5, 2011.
[Journal]
44)  Kakareka JW, McCann TE, Kosaka N, Mitsunaga M, Morgan NY, Pohida TJ, Choyke PL, Kobayashi H.
A Portable Fluorescence Camera for Testing Surgical Specimens in the Operating Room: Description and Early Evaluation.
Mol Imaging Biol. 13: 862-7, 2010.
[Journal]
45)  McCann TE, Kosaka N, Mitsunaga M, Choyke PL, Gildersleeve JC, Kobayashi H.
Biodistribution and excretion of monosaccharide-albumin conjugates measured with in vivo near-infrared fluorescence imaging.
Bioconjug. Chem. 21: 1925-32, 2010.
[Journal]
46)  Alford R, Ogawa M, Hassan M, Gandjbakhche AH, Choyke PL, Kobayashi H.
Fluorescence lifetime imaging of activatable target specific molecular probes.
Contrast Media Mol Imaging. 5: 1-8, 2010.
[Journal]
47)  Ogawa M, Kosaka N, Regino CA, Mitsunaga M, Choyke PL, Kobayashi H.
High sensitivity detection of cancer in vivo using a dual-controlled activation fluorescent imaging probe based on H-dimer formation and pH activation.
Mol Biosyst. 6: 888-93, 2010.
[Journal]
48)  Rosenblum LT, Kosaka N, Mitsunaga M, Choyke PL, Kobayashi H.
In vivo molecular imaging using nanomaterials: General in vivo characteristics of nano-sized reagents and applications for cancer diagnosis (Review).
Mol Membr Biol. 27: 274-85, 2010.
[Journal]
49)  Sena LM, Fishman SJ, Jenkins KJ, Xu H, Brechbiel MW, Regino CA, Kosaka N, Bernardo M, Choyke PL, Kobayashi H.
Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models.
Nanomedicine (Lond). 5: 1183-91, 2010.
[Journal]
50)  Kobayashi H, Longmire MR, Ogawa M, Choyke PL, Kawamoto S.
Multiplexed imaging in cancer diagnosis: applications and future advances.
Lancet Oncol. 11: 589-95, 2010.
[Journal]
51)  Ogawa M, Regino CA, Marcelino B, Williams M, Kosaka N, Bryant LH, Choyke PL, Kobayashi H.
New nanosized biocompatible MR contrast agents based on lysine-dendri-graft macromolecules.
Bioconjug. Chem. 21: 955-60, 2010.
[Journal]
52)  Kobayashi H, Ogawa M, Alford R, Choyke PL, Urano Y.
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging.
Chemical Rev. 110: 2620-40, 2010.
[Journal]
53)  Rosenblum LT, Kosaka N, Mitsunaga M, Choyke PL, Kobayashi H.
Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots.
Contrast Media Mol Imaging. 6: 148-52, 2010.
[Journal]
54)  Kosaka N, McCann TE, Mitsunaga M, Choyke PL, Kobayashi H.
Real-time optical imaging using quantum dot and related nanocrystals.
Nanomedicine (Lond). 5: 765-76, 2010.
[Journal]
55)  Kosaka N, Mitsunaga M, Bhattacharyya S, Miller SC, Choyke PL, Kobayashi H.
Self-illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano-particle.
Contrast Media Mol Imaging. 6: 55-9, 2010.
[Journal]
56)  Kosaka N, Ogawa M, Paik DS, Paik CH, Choyke PL, Kobayashi H.
Semiquantitative assessment of the microdistribution of fluorescence-labeled monoclonal antibody in small peritoneal disseminations of ovarian cancer.
Cancer Sci. 101: 820-5, 2010.
[Journal]
57)  Regino CA, Ogawa M, Alford R, Wong KJ, Kosaka N, Williams M, Feild BJ, Takahashi M, Choyke PL, Kobayashi H.
Two-Step Synthesis of Galactosylated Human Serum Albumin as a Targeted Optical Imaging Agent for Peritoneal Carcinomatosis.
J Med Chem. 53: 1579-86, 2010.
[Journal]
58)  Kosaka N, Ogawa M, Choyke PL, Kobayashi H.
Clinical implications of near-infrared fluorescence imaging in cancer.
Future Oncol. 5: 1501-11, 2009.
[Journal]
59)  Barrett T, Ravizzini G, Choyke PL, Kobayashi H.
Dendrimers in medical nanotechnology.
IEEE Eng Med Biol Mag. 28: 12-22, 2009.
[Journal]
60)  Ogawa M, Regino CA, Seidel J, Green MV, Xi W, Williams M, Kosaka N, Choyke PL, Kobayashi H.
Dual-modality molecular imaging using antibodies labeled with activatable fluorescence and a radionuclide for specific and quantitative targeted cancer detection.
Bioconjug. Chem. 20: 2177-84, 2009.
[Journal]
61)  Ogawa M, Kosaka N, Longmire MR, Urano Y, Choyke PL, Kobayashi H.
Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases.
Mol. Pharm. 6: 386-95, 2009.
[Journal]
62)  Ogawa M, Kosaka N, Choyke PL, Kobayashi H.
H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging.
ACS Chem. Biol. 4: 535-46, 2009.
[Journal]
63)  Turkbey B, Kobayashi H, Ogawa M, Bernardo M, Choyke PL.
Imaging of tumor angiogenesis: functional or targeted?.
AJR. Am J Roentgenol. 193: 304-13, 2009.
[Journal]
64)  Ogawa M, Kosaka N, Choyke PL, Kobayashi H.
In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.
Cancer Res. 69: 1268-72, 2009.
[Journal]
65)  Kosaka N, Ogawa M, Sato N, Choyke PL, Kobayashi H.
In Vivo Real-Time, Multicolor, Quantum Dot Lymphatic Imaging.
J. Invest. Dermatol. 129: 2818-22, 2009.
[Journal]
66)  Kosaka N, Ogawa M, Choyke PL, Karassina N, Corona C, McDougall M, Lynch DT, Hoyt CC, Levenson RM, Los GV, Kobayashi H.
In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands.
Bioconjug. Chem. 20: 1367-74, 2009.
[Journal]
67)  Ogawa M, Regino CA, Choyke PL, Kobayashi H.
In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies.
Mol. Cancer Ther. 8: 232-9, 2009.
[Journal]
68)  Alford R, Ogawa M, Choyke PL, Kobayashi H.
Molecular probes for the in vivo imaging of cancer.
Mol Biosyst. 5: 1279-91, 2009.
[Journal]
69)  Kosaka N, Ogawa M, Longmire MR, Choyke PL, Kobayashi H.
Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer.
J Biomed Opt. 14: 014023, 2009.
[Journal]
70)  Kobayashi H, Ogawa M, Kosaka N, Choyke PL, Urano Y.
Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents.
Nanomedicine. 4: 411-9, 2009.
[Journal]
71)  Longmire M, Kosaka N, Ogawa M, Choyke PL, Kobayashi H.
Multicolor in vivo targeted imaging to guide real-time surgery of HER2-positive micrometastases in a two-tumor coincident model of ovarian cancer.
Cancer Sci. 100: 1099-104, 2009.
[Journal]
72)  Ravizzini G, Turkbey B, Barrett T, Kobayashi H, Choyke PL.
Nanoparticles in sentinel lymph node mapping.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 1: 610-23, 2009.
[Journal]
73)  Urano Y, Asanuma D, Hama Y, Koyama Y, Barrett T, Kamiya M, Nagano T, Watanabe T, Hasegawa A, Choyke PL, Kobayashi H.
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes.
Nat. Med. 15: 104-9, 2009.
[Journal]
74)  Alford R, Simpson HM, Duberman J, Hill GC, Ogawa M, Regino C, Kobayashi H, Choyke PL.
Toxicity of organic fluorophores used in molecular imaging: literature review.
Mol Imaging. 8: 341-54, 2009.
[Journal]
75)  Ogawa M, Kosaka N, Choyke PL, Kobayashi H.
Tumor-specific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin.
Bioconjug. Chem. 20: 147-54, 2009.
[Journal]
76)  Longmire M, Choyke PL, Kobayashi H.
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
Nanomedicine. 3: 703-17, 2008.
[Journal]
77)  Longmire M, Choyke PL, Kobayashi H.
Dendrimer-based contrast agents for molecular imaging.
Curr Top Med Chem. 8: 1180-6, 2008.
[Journal]
78)  Longmire MR, Ogawa M, Hama Y, Kosaka N, Regino CA, Choyke PL, Kobayashi H.
Determination of optimal rhodamine fluorophore for in vivo optical imaging.
Bioconjug. Chem. 19: 1735-42, 2008.
[Journal]
79)  Levenson RM, Lynch DT, Kobayashi H, Backer JM, Backer MV.
Multiplexing with multispectral imaging: from mice to microscopy.
ILAR J. 49: 78-88, 2008.
[Journal]
80)  Kurdziel K, Ravizzini G, Croft B, Tatum J, Choyke P, Kobayashi H.
The evolving role of nuclear molecular imaging in cancer.
Expert Opin Med Diagn. 2: 829-842, 2008.
[Journal]
81)  Koyama Y, Talanov VS, Bernardo M, Hama Y, Regino CA, Brechbiel MW, Choyke PL, Kobayashi H.
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
J Magn Reson Imaging. 25: 866-71, 2007.
[Journal]
82)  Hama Y, Urano Y, Koyama Y, Gunn AJ, Choyke PL, Kobayashi H.
A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a.
Clin. Cancer Res. 13: 6335-43, 2007.
[Journal]
83)  Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Shin IS, Paik CH, Choyke PL, Kobayashi H.
A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.
Cancer Res. 67: 2791-9, 2007.
[Journal]
84)  Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody.
Cancer Res. 67: 3809-17, 2007.
[Journal]
85)  Kamiya M, Kobayashi H, Hama Y, Koyama Y, Bernardo M, Nagano T, Choyke PL, Urano Y.
An enzymatically activated fluorescence probe for targeted tumor imaging.
J. Am. Chem. Soc. 129: 3918-29, 2007.
[Journal]
86)  Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green.
J Biomed Opt. 12: 051501, 2007.
[Journal]
87)  Barrett T, Koyama Y, Hama Y, Ravizzini G, Shin IS, Jang BS, Paik CH, Urano Y, Choyke PL, Kobayashi H.
In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.
Clin. Cancer Res. 13: 6639-48, 2007.
[Journal]
88)  Koyama Y, Barrett T, Hama Y, Ravizzini G, Choyke PL, Kobayashi H.
In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies.
Neoplasia. 9: 1021-9, 2007.
[Journal]
89)  Hama Y, Bernardo M, Regino CA, Koyama Y, Brechbiel MW, Krishna MC, Choyke PL, Kobayashi H.
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magn Reson Med. 57: 431-6, 2007.
[Journal]
90)  Kobayashi H, Koyama Y, Barrett T, Hama Y, Regino CA, Shin IS, Jang B, Le N, Paik CH, Choyke PL, Urano Y.
Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging.
ACS Nano. 1: 258-64, 2007.
[Journal]
91)  Xu H, Regino CA, Koyama Y, Hama Y, Gunn AJ, Bernardo M, Kobayashi H, Choyke PL, Brechbiel MW.
Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.
Bioconjug. Chem. 18: 1474-82, 2007.
[Journal]
92)  Kobayashi H, Hama Y, Koyama Y, Barrett T, Regino CA, Urano Y, Choyke PL.
Simultaneous multicolor imaging of five different lymphatic basins using quantum dots.
Nano Lett. 7: 1711-6, 2007.
[Journal]
93)  Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity.
Breast Cancer Res. Treat. 103: 23-8, 2007.
[Journal]
94)  Kakinuma T, Nadiminti H, Lonsdorf AS, Murakami T, Perez BA, Kobayashi H, Finkelstein SE, Pothiawala G, Belkaid Y, Hwang ST.
Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location.
Cancer Immunol. Immunother. 56: 1119-31, 2007.
[Journal]
95)  Koyama Y, Hama Y, Urano Y, Nguyen DM, Choyke PL, Kobayashi H.
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu.
Clin. Cancer Res. 13: 2936-45, 2007.
[Journal]
96)  Hama Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms.
Contrast Media Mol Imaging. 2: 82-7, 2007.
[Journal]
97)  Gunn AJ, Hama Y, Koyama Y, Kohn EC, Choyke PL, Kobayashi H.
Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore.
Cancer Sci. 98: 1727-33, 2007.
[Journal]
98)  Xu H, Regino CA, Bernardo M, Koyama Y, Kobayashi H, Choyke PL, Brechbiel MW.
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
J. Med. Chem. 50: 3185-93, 2007.
[Journal]
99)  Hama Y, Koyama Y, Choyke PL, Kobayashi H.
Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging.
J Biomed Opt. 12: 034016, 2007.
[Journal]
100)  Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Two-color lymphatic mapping using Ig-conjugated near infrared optical probes.
J. Invest. Dermatol. 127: 2351-6, 2007.
[Journal]
101)  Hama Y, Urano Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.
Bioconjug. Chem. 17: 1426-31, 2006.
[Journal]
102)  Kobayashi H, Kawamoto S, Bernardo M, Brechbiel MW, Knopp MV, Choyke PL.
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
J Control Release. 111: 343-51, 2006.
[Journal]
103)  Talanov VS, Regino CA, Kobayashi H, Bernardo M, Choyke PL, Brechbiel MW.
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano Lett. 6: 1459-63, 2006.
[Journal]
104)  Dear JW, Kobayashi H, Brechbiel MW, Star RA.
Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.
Nephron Clin Pract. 103: c45-9, 2006.
[Journal]
105)  Barrett T, Choyke PL, Kobayashi H.
Imaging of the lymphatic system: new horizons.
Contrast Media Mol Imaging. 1: 230-45, 2006.
[Journal]
106)  Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Krishna MC, Choyke PL, Kobayashi H.
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.
Neoplasia. 8: 607-12, 2006.
[Journal]
107)  Barrett T, Kobayashi H, Brechbiel M, Choyke PL.
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
Eur J Radiol. 60: 353-66, 2006.
[Journal]
108)  Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.
Biochem. Biophys. Res. Commun. 348: 807-13, 2006.
[Journal]
109)  Dear JW, Kobayashi H, Jo SK, Holly MK, Hu X, Yuen PS, Brechbiel MW, Star RA.
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.
Kidney Int. 67: 2159-67, 2005.
[Journal]
110)  Kobayashi H, Kawamoto S, Brechbiel MW, Bernardo M, Sato N, Waldmann TA, Tagaya Y, Choyke PL.
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia. 7: 984-91, 2005.
[Journal]
111)  Choyke PL, Kobayashi H.
Functional magnetic resonance imaging of the kidney using macromolecular contrast agents.
Abdom Imaging. 31: 224-31, 2005.
[Journal]
112)  Sugaya M, Watanabe T, Yang A, Starost MF, Kobayashi H, Atkins AM, Borris DL, Hanan EA, Schimel D, Bryant MA, Roberts N, Skobe M, Staskus KA, Kaldis P, Blauvelt A.
Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.
Blood. 105: 2356-63, 2005.
[Journal]
113)  Kobayashi H, Brechbiel MW.
Nano-sized MRI contrast agents with dendrimer cores.
Adv. Drug Deliv. Rev. 57: 2271-86, 2005.
[Journal]
114)  Kataoka ML, Togashi K, Yamaoka T, Koyama T, Ueda H, Kobayashi H, Rahman M, Higuchi T, Fujii S.
Posterior cul-de-sac obliteration associated with endometriosis: MR imaging evaluation.
Radiology. 234: 815-23, 2005.
[Journal]
115)  Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, Tagaya Y.
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.
Blood. 105: 721-7, 2005.
[Journal]
116)  Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clin. Cancer Res. 10: 7712-20, 2004.
[Journal]
117)  Kobayashi H, Brechbiel MW.
Dendrimer-based nanosized MRI contrast agents.
Curr Pharm Biotechnol. 5: 539-49, 2004.
[Journal]
118)  Mamede M, Saga T, Ishimori T, Higashi T, Sato N, Kobayashi H, Brechbiel MW, Konishi J.
Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.
J Control Release. 95: 133-41, 2004.
[Journal]
119)  Mandler R, Kobayashi H, Hinson ER, Brechbiel MW, Waldmann TA.
Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer Res. 64: 1460-7, 2004.
[Journal]
120)  Kobayashi H, Kawamoto S, Sakai Y, Choyke PL, Star RA, Brechbiel MW, Sato N, Tagaya Y, Morris JC, Waldmann TA.
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
J. Natl. Cancer Inst. 96: 703-8, 2004.
[Journal]
121)  Kobayashi H, Kawamoto S, Brechbiel MW, Jo SK, Hu X, Yang T, Diwan BA, Waldmann TA, Schnermann J, Choyke PL, Star RA.
Micro-MRI methods to detect renal cysts in mice.
Kidney Int. 65: 1511-6, 2004.
[Journal]
122)  Kobayashi H, Jo S, Kawamoto S, Yasuda H, Hu X, Knopp MV, Brechbiel MW, Choyke PL, Star RA.
Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.
J Magn Reson Imaging. 20: 512-8, 2004.
[Journal]
123)  Kobayashi H, Kawamoto S, Star RA, Waldmann TA, Brechbiel MW, Choyke PL.
Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.
Bioconjug. Chem. 14: 1044-7, 2003.
[Journal]
124)  Kobayashi H, Kawamoto S, Choyke PL, Sato N, Knopp MV, Star RA, Waldmann TA, Tagaya Y, Brechbiel MW.
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.
Magn Reson Med. 50: 758-66, 2003.
[Journal]
125)  Kobayashi H, Brechbiel MW.
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Mol Imaging. 2: 1-10, 2003.
[Journal]
126)  Jo SK, Hu X, Kobayashi H, Lizak M, Miyaji T, Koretsky A, Star RA.
Detection of inflammation following renal ischemia by magnetic resonance imaging.
Kidney Int. 64: 43-51, 2003.
[Journal]
127)  Mamede M, Saga T, Ishimori T, Nakamoto Y, Sato N, Higashi T, Mukai T, Kobayashi H, Konishi J.
Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification.
Neoplasia. 5: 179-83, 2003.
[Journal]
128)  Shirakawa K, Kobayashi H, Sobajima J, Hashimoto D, Shimizu A, Wakasugi H.
Inflammatory breast cancer: vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model.
Breast Cancer Res. 5: 136-9, 2003.
[Journal]
129)  Kobayashi H, Kawamoto S, Jo SK, Bryant HL, Brechbiel MW, Star RA.
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Bioconjug. Chem. 14: 388-94, 2003.
[Journal]
130)  Kobayashi H, Kawamoto S, Star RA, Waldmann TA, Tagaya Y, Brechbiel MW.
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.
Cancer Res. 63: 271-6, 2003.
[Journal]
131)  Nakamoto Y, Saga T, Higashi T, Ishimori T, Kobayashi H, Ishizu K, Sato N, Mamede M, Sakahara H, Imamura M, Konishi J.
Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose.
Ann Nucl Med. 17: 421-6, 2003.
[Journal]
132)  Mamede M, Saga T, Kobayashi H, Ishimori T, Higashi T, Sato N, Brechbiel MW, Konishi J.
Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.
Clin. Cancer Res. 9: 3756-62, 2003.
[Journal]
133)  Nakai A, Togashi K, Yamaoka T, Fujiwara T, Ueda H, Koyama T, Kobayashi H, Kagimura T, Fujii S, Konishi J.
Uterine peristalsis shown on cine MR imaging using ultrafast sequence.
J Magn Reson Imaging. 18: 726-33, 2003.
[Journal]
134)  Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, Kasumi F, Iwanaga T, Konishi F, Terada M, Wakasugi H.
Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.
Cancer Res. 62: 560-6, 2002.
[Journal]
135)  Kim MK, Jeong HJ, Kao CH, Yao Z, Paik DS, Pie JE, Kobayashi H, Waldmann TA, Carrasquillo JA, Paik CH.
Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications.
Nucl. Med. Biol. 29: 139-46, 2002.
[Journal]
136)  Ishimori T, Saga T, Mamede M, Kobayashi H, Higashi T, Nakamoto Y, Sato N, Konishi J.
Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.
J. Nucl. Med. 43: 658-63, 2002.
[Journal]
137)  Kim I, Kobayashi H, Yoo TM, Kim MK, Le N, Han ES, Wang QC, Pastan I, Carrasquillo JA, Paik CH.
Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.
Nucl. Med. Biol. 29: 795-801, 2002.
[Journal]
138)  Mandler R, Kobayashi H, Davis MY, Waldmann TA, Brechbiel MW.
Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.
Bioconjug. Chem. 13: 786-91, 2002.
[Journal]
139)  Kobayashi H, Shirakawa K, Kawamoto S, Saga T, Sato N, Hiraga A, Watanabe I, Heike Y, Togashi K, Konishi J, Brechbiel MW, Wakasugi H.
Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256).
Cancer Res. 62: 860-6, 2002.
[Journal]
140)  Kobayashi H, Kawamoto S, Jo SK, Sato N, Saga T, Hiraga A, Konishi J, Hu S, Togashi K, Brechbiel MW, Star RA.
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.
Kidney Int. 61: 1980-5, 2002.
[Journal]
141)  Nakai T, Muraki S, Kato C, Sugio T, Matsuo K, Miki Y, Kobayashi H, Ueda H, Ogata M, Liu X, Konishi J, Togashi K.
[Development of three-dimensional stereo viewer for high-resolution data].
Nihon Igaku Hoshasen Gakkai Zasshi. Nippon acta radiologica. 61: 103-5, 2001.
[Journal]
142)  Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent.
Magn Reson Med. 46: 579-85, 2001.
[Journal]
143)  Kobayashi H, Sato N, Hiraga A, Saga T, Nakamoto Y, Ueda H, Konishi J, Togashi K, Brechbiel MW.
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties.
Magn Reson Med. 45: 454-60, 2001.
[Journal]
144)  Kobayashi H, Kawamoto S, Saga T, Sato N, Ishimori T, Konishi J, Ono K, Togashi K, Brechbiel MW.
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.
Bioconjug. Chem. 12: 587-93, 2001.
[Journal]
145)  Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Haque TL, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer.
Bioconjug. Chem. 12: 100-7, 2001.
[Journal]
146)  Kobayashi H, Saga T, Kawamoto S, Sato N, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).
Cancer Res. 61: 4966-70, 2001.
[Journal]
147)  Saga T, Sakahara H, Nakamoto Y, Sato N, Ishimori T, Mamede M, Kobayashi H, Masunaga S, Sasai K, Kuroki M, Konishi J.
Enhancement of the therapeutic outcome of radio-immunotherapy by combination with whole-body mild hyperthermia.
Eur. J. Cancer. 37: 1429-34, 2001.
[Journal]
148)  Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Konishi J, Togashi K, Brechbiel MW.
Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents.
J Magn Reson Imaging. 14: 705-13, 2001.
[Journal]
149)  Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
Magn Reson Med. 46: 457-64, 2001.
[Journal]
150)  Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Ishimori T, Akita Y, Mamede MH, Konishi J, Togashi K, Brechbiel MW.
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core.
Magn Reson Med. 46: 795-802, 2001.
[Journal]
151)  Sato N, Kobayashi H, Hiraga A, Saga T, Togashi K, Konishi J, Brechbiel MW.
Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores.
Magn Reson Med. 46: 1169-73, 2001.
[Journal]
152)  Kobayashi H, Kawamoto S, Tamaki T, Konishi J, Togashi K.
Polysplenia associated with semiannular pancreas.
Eur Radiol. 11: 1639-41, 2001.
[Journal]
153)  Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.
Magn Reson Med. 46: 781-8, 2001.
[Journal]
154)  Sato N, Kobayashi H, Saga T, Nakamoto Y, Ishimori T, Togashi K, Fujibayashi Y, Konishi J, Brechbiel MW.
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clin. Cancer Res. 7: 3606-12, 2001.
[Journal]
155)  Haque TL, Togashi K, Kobayashi H, Fujii S, Konishi J.
Adnexal torsion: MR imaging findings of viable ovary.
Eur Radiol. 10: 1954-7, 2000.
[Journal]
156)  Kobayashi H, Togashi K.
CT of tattoos removed with laser therapy.
AJR Am J Roentgenol. 174: 1468-9, 2000.
[Journal]
157)  Kobayashi H, Carrasquillo JA, Paik CH, Waldmann TA, Tagaya Y.
Differences of biodistribution, pharmacokinetics, and tumor targeting between interleukins 2 and 15.
Cancer Res. 60: 3577-83, 2000.
[Journal]
158)  Sun BF, Kobayashi H, Le N, Yoo TM, Drumm D, Paik CH, McAfee JG, Carrasquillo JA.
Effects of insulinlike growth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice.
J. Nucl. Med. 41: 318-26, 2000.
[Journal]
159)  Nakamoto Y, Saga T, Misaki T, Kobayashi H, Sato N, Ishimori T, Kosugi S, Sakahara H, Konishi J.
Establishment and characterization of a breast cancer cell line expressing Na+/I- symporters for radioiodide concentrator gene therapy.
J. Nucl. Med. 41: 1898-904, 2000.
[Journal]
160)  Kobayashi H, Sato N, Saga T, Nakamoto Y, Ishimori T, Toyama S, Togashi K, Konishi J, Brechbiel MW.
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity.
Eur J Nucl Med. 27: 1334-9, 2000.
[Journal]
161)  Kobayashi H, Kao CH, Kreitman RJ, Le N, Kim MK, Brechbiel MW, Paik CH, Pastan I, Carrasquillo JA.
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
J. Nucl. Med. 41: 755-62, 2000.
[Journal]
162)  Kim IS, Yoo TM, Kobayashi H, Kim MK, Le N, Wang QC, Pastan I, Carrasquillo JA, Paik CH.
Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.
Bioconjug. Chem. 10: 447-53, 1999.
[Journal]
163)  Kim M, Seidel J, Le N, Kim IS, Yoo TM, Barker C, Kobayashi H, Green MV, Carrasquillo JA, Paik CH.
Evaluation of 99mTc-mercaptoacetyltriglycine-biocytin as a new hepatobiliary imaging agent in mice coinjected with bilirubin.
Nucl. Med. Biol. 26: 43-9, 1999.
[Journal]
164)  Kataoka ML, Togashi K, Kobayashi H, Inoue T, Fujii S, Konishi J.
Evaluation of ectopic pregnancy by magnetic resonance imaging.
Hum. Reprod. 14: 2644-50, 1999.
[Journal]
165)  Kobayashi H, Wu C, Kim MK, Paik CH, Carrasquillo JA, Brechbiel MW.
Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.
Bioconjug. Chem. 10: 103-11, 1999.
[Journal]
166)  Kobayashi H, Kim IS, Drumm D, Kim MK, Paik DS, Le N, Waldmann TA, Carrasquillo JA, Paik CH.
Favorable effects of glycolate conjugation on the biodistribution of humanized antiTac Fab fragment.
J. Nucl. Med. 40: 837-45, 1999.
[Journal]
167)  Kobayashi H, Sun BF, Yoo TM, Le N, Kim MK, Paik CH, Pastan I, Waldmann TA, Carrasquillo JA.
Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.
J. Nucl. Med. 40: 1381-91, 1999.
[Journal]
168)  Koyama T, Togashi K, Konishi I, Kobayashi H, Ueda H, Kataoka ML, Kobayashi H, Itoh T, Higuchi T, Fujii S, Konishi J.
MR imaging of endometrial stromal sarcoma: correlation with pathologic findings.
AJR Am J Roentgenol. 173: 767-72, 1999.
[Journal]
169)  Kobayashi H, Le N, Kim IS, Kim MK, Pie JE, Drumm D, Paik DS, Waldmann TA, Paik CH, Carrasquillo JA.
The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points.
Cancer Res. 59: 422-30, 1999.
[Journal]
170)  Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, Kobayashi H, Fujii S, Konishi J.
Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds.
Radiographics. 19 Spec No: S131-45, 1999.
[Journal]
171)  Kobayashi H, Tagaya Y, Han ES, Kim IS, Le N, Paik CH, Pastan I, Nelson DL, Waldmann TA, Carrasquillo JA.
Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.
Cytokine. 11: 1065-75, 1999.
[Journal]
172)  Kobayashi H, Sun BF, Han ES, Kim MK, Le N, Wang QC, Nelson DL, Pastan I, Waldmann TA, Paik CH, Carrasquillo JA.
Epitope blocking: positive and negative effects on the biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment of two antibodies against different epitopes of the circulating antigen.
Jpn. J. Cancer Res. 89: 436-44, 1998.
[Journal]
173)  Kobayashi H, Wu C, Yoo TM, Sun BF, Drumm D, Pastan I, Paik CH, Gansow OA, Carrasquillo JA, Brechbiel MW.
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
J. Nucl. Med. 39: 829-36, 1998.
[Journal]
174)  Yao Z, Zhang M, Sakahara H, Saga T, Kobayashi H, Nakamoto Y, Toyama S, Konishi J.
Increased streptavidin uptake in tumors pretargeted with biotinylated antibody using a conjugate of streptavidin-fab fragment.
Nucl. Med. Biol. 25: 557-60, 1998.
[Journal]
175)  Kobayashi H, Han ES, Kim IS, Le N, Rajagopal V, Kreitman RJ, Pastan I, Paik CH, Carrasquillo JA.
Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment.
Nucl. Med. Biol. 25: 387-93, 1998.
[Journal]
176)  Kim MK, Song BJ, Seidel J, Soh Y, Jeong KS, Kim IS, Kobayashi H, Green MV, Carrasquillo JA, Paik CH.
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Nucl. Med. Biol. 25: 561-8, 1998.
[Journal]
177)  Sun BF, Kobayashi H, Le N, Yoo TM, Drumm D, Paik CH, McAfee JG, Carrasquillo JA.
Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism.
Cancer Res. 57: 2754-9, 1997.
[Journal]
178)  Kobayashi H, Yoo TM, Drumm D, Kim MK, Sun BF, Le N, Webber KO, Pastan I, Waldmann TA, Paik CH, Carrasquillo JA.
Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
Cancer Res. 57: 1955-61, 1997.
[Journal]
179)  Hosono M, Kobayashi H, Fujimoto R, Tsutsui K, Kotoura Y, Tsuboyama T, Hayashi H, Nakamura T, Konishi J.
MR appearance of parasymphseal insufficiency fractures of the os pubis.
Skeletal Radiol. 26: 525-8, 1997.
[Journal]
180)  Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Endo K, Konishi J.
MRI and scintigraphic features of extraabdominal desmoid tumors.
Clin Imaging. 21: 35-9, 1997.
[Journal]
181)  Hosono M, Kobayashi H, Fujimoto R, Kotoura Y, Tsuboyama T, Matsusue Y, Nakamura T, Itoh T, Konishi J.
Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation.
Skeletal Radiol. 26: 150-4, 1997.
[Journal]
182)  Wu C, Kobayashi H, Sun B, Yoo TM, Paik CH, Gansow OA, Carrasquillo JA, Pastan I, Brechbiel MW.
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorg. Med. Chem. 5: 1925-34, 1997.
[Journal]
183)  Nakamoto Y, Sakahara H, Kobayashi H, Saga T, Tsuboyama N, Nakamura T, Konishi J.
Technetium-99m (V)-dimercaptosuccinic acid: normal accumulation in the breasts.
Eur J Nucl Med. 24: 1146-8, 1997.
[Journal]
184)  Kobayashi H, Shigeno C, Sakahara H, Yamamoto T, Hosono M, Fujimoto R, Konishi J.
Three phase 99Tcm (V)DMSA scintigraphy in Paget's disease: an indicator of pamidronate effect.
Br J Radiol. 70: 1056-9, 1997.
[Journal]
185)  Kobayashi H, Itoh T, Sasaki Y, Konishi J.
Diagnostic imaging of idiopathic adult respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD) histopathological correlation with radiological imaging.
Clin Imaging. 20: 1-7, 1996.
[Journal]
186)  Sakahara H, Hosono M, Kobayashi H, Yao Z, Saga T, Yano S, Endo K, Mori T, Konishi J.
Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.
Jpn. J. Cancer Res. 87: 655-61, 1996.
[Journal]
187)  Kobayashi H, Sakahara H, Endo K, Yao ZS, Konishi J.
Inflammation-seeking scintigraphy with radiolabeled biotinylated polyclonal IgG followed by the injection of avidin chase.
Nucl. Med. Biol. 23: 29-32, 1996.
[Journal]
188)  Kobayashi H, Yoo TM, Kim IS, Kim MK, Le N, Webber KO, Pastan I, Paik CH, Eckelman WC, Carrasquillo JA.
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer Res. 56: 3788-95, 1996.
[Journal]
189)  Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J.
Periosteal ganglion of the tibia.
Skeletal Radiol. 25: 381-3, 1996.
[Journal]
190)  Kobayashi H, Kotoura Y, Hosono M, Fujimoto R, Tsuboyama T, Itoh H, Konishi J.
3D-spiral CT of multiple exostoses.
Comput Med Imaging Graph. 19: 419-22, 1995.
[Journal]
191)  Kobayashi H, Sakahara H, Endo K, Hosono M, Yao ZS, Toyama S, Konishi J.
Comparison of the chase effects of avidin, streptavidin, neutravidin, and avidin-ferritin on a radiolabeled biotinylated anti-tumor monoclonal antibody.
Jpn. J. Cancer Res. 86: 310-4, 1995.
[Journal]
192)  Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Hosono M, Yao ZS, Tsuboyama T, Yamamuro T, Endo K, Konishi J.
Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy.
Clin Nucl Med. 20: 361-4, 1995.
[Journal]
193)  Kobayashi H, Itoh T, Itoh H, Konishi J.
Duct ectasia due to mucus-producing cancers with intraductal extension: histopathologic correlation with radiologic imagings.
Abdom Imaging. 20: 341-7, 1995.
[Journal]
194)  Yao Z, Zhang M, Kobayashi H, Sakahara H, Nakada H, Yamashina I, Konishi J.
Improved targeting of radiolabeled streptavidin in tumors pretargeted with biotinylated monoclonal antibodies through an avidin chase.
J. Nucl. Med. 36: 837-41, 1995.
[Journal]
195)  Kobayashi H, Kotoura Y, Tsuboyama T, Hosono M, Sakahara H, Konishi J.
Incidental detection of papillary carcinoma of the thyroid by Tc-99m (V) DMSA tumor scintigraphy.
Clin Nucl Med. 20: 638, 1995.
[Journal]
196)  Hosono M, Kobayashi H, Kotoura Y, Tsuboyama T, Tsutsui K, Konishi J.
Involvement of muscle by malignant lymphoma: MR and CT appearances.
J Comput Assist. Tomogr. 19: 455-9, 1995.
[Journal]
197)  Hosono M, Sone N, Endo K, Saga T, Kobayashi H, Hosono MN, Sakahara H, Yasunaga K, Konishi J.
Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody.
Nucl. Med. Biol. 22: 71-6, 1995.
[Journal]
198)  Kobayashi H, Suzuki KH, Sakahara H, Yao ZS, Yokoyama A, Konishi J.
Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.
Eur J Nucl Med. 22: 559-62, 1995.
[Journal]
199)  Kobayashi H, Itoh T, Shima N, Kudoh T, Shibuya K, Maekawa T, Kogawa K, Konishi J.
Periduodenal panniculitis due to spontaneous rupture of a pancreatic pseudocyst into the duodenum.
Abdom Imaging. 20: 106-8, 1995.
[Journal]
200)  Hosono M, Takaori-Kondo A, Yao ZS, Kobayashi H, Hosono MN, Sakahara H, Imada K, Okuma M, Uchiyama T, Konishi J.
Radioimmunodetection of human leukemia with anti-interleukin-2 receptor antibody in severe combined immunodeficiency mice.
Nucl. Med. Biol. 22: 869-74, 1995.
[Journal]
201)  Yao Z, Sakahara H, Zhang M, Kobayashi H, Nakada H, Yamashina I, Konishi J.
Radioimmunoimaging of colon cancer xenografts with anti-Tn monoclonal antibody.
Nucl. Med. Biol. 22: 199-203, 1995.
[Journal]
202)  Kobayashi H, Sakahara H, Endo K, Yao ZS, Toyama S, Konishi J.
Repeating the avidin.
Eur. J. Cancer. 31A: 1689-96, 1995.
[Journal]
203)  Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J.
Solitary muscular involvement by tuberculosis: CT, MRI, and scintigraphic features.
Comput Med Imaging Graph. 19: 237-40, 1995.
[Journal]
204)  Kobayashi H, Hosono M, Fujimoto R, Konishi J.
Tumoral calcinosis-like metastatic calcification in a patient with renal osteodystrophy: CT and scintigraphic appearances.
Clin Nucl Med. 20: 1112-4, 1995.
[Journal]
205)  Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Nishijima N, Sakahara H, Konishi J.
Uptake of pentavalent technetium-99m dimercaptosuccinic acid in idiopathic synovial chondromatosis.
Ann Nucl Med. 9: 153-5, 1995.
[Journal]
206)  Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Yamamuro T, Endo K, Konishi J.
Case report: uptake of pentavalent technetium-99m dimercaptosuccinic acid by pigmented villonodular synovitis: comparison with computed tomography, magnetic resonance imaging and gallium-67 scintigraphy.
Br J Radiol. 67: 1030-2, 1994.
[Journal]
207)  Kobayashi H, Itoh T, Murata R, Konishi J.
Detection of intrarenal venous invasions of malignant renal neoplasms by retrograde renal venography.
Clin Imaging. 18: 115-8, 1994.
[Journal]
208)  Kobayashi H, Sakahara H, Hosono M, Yao ZS, Toyama S, Endo K, Konishi J.
Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a.
J. Nucl. Med. 35: 1677-84, 1994.
[Journal]
209)  Kobayashi H, Shigeno C, Sakahara H, Hosono M, Hosono M, Yao ZS, Endo K, Konishi J.
Intraosseous hemangiomatosis: technetium-99m(V)dimercaptosuccinic acid and technetium-99m-hydroxymethylene diphosphonate imaging.
J. Nucl. Med. 35: 1482-4, 1994.
[Journal]
210)  Sakahara H, Onodera H, Kobayashi H, Yao Z, Yamashina I, Konishi J.
Reduced bone marrow uptake of indium-111 labelled monoclonal antibody after radiotherapy.
Eur J Nucl Med. 21: 1252-3, 1994.
[Journal]
211)  Kobayashi H, Kotoura Y, Sakahara H, Hosono M, Hosono M, Tsaboyama T, Yamamuro T, Endo K, Konishi J.
Schwannoma of the extremities: comparison of MRI and pentavalent technetium-99m-dimercaptosuccinic acid and gallium-67-citrate scintigraphy.
J. Nucl. Med. 35: 1174-8, 1994.
[Journal]
212)  Kobayashi H, Sakahara H, Hosono M, Shirato M, Kondo S, Miyatake S, Kikuchi H, Namba Y, Endo K, Konishi J.
Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody.
J. Cancer Res. Clin. Oncol. 120: 259-62, 1994.
[Journal]
213)  Kobayashi H, Sakahara H, Hosono M, Shirato M, Endo K, Kotoura Y, Yamamuro T, Konishi J.
Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy.
Radiology. 190: 277-80, 1994.
[Journal]
214)  Kobayashi H, Kotoura Y, Sakahara H, Yamamuro T, Endo K, Konishi J.
Solitary muscular sarcoidosis: CT, MRI, and scintigraphic characteristics.
Skeletal Radiol. 23: 293-5, 1994.
[Journal]
215)  Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Takahashi JA, Oda Y, Kikuchi H, Endo K, Kozai Y.
Scintigraphic detection of xenografted tumors producing human basic fibroblast growth factor.
Cancer Immunol. Immunother. 37: 281-5, 1993.
[Journal]
216)  Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Kotoura Y, Yamamuro T, Endo K.
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid.
J. Nucl. Med. 34: 1745-7, 1993.
[Journal]
217)  Kobayashi H, Sakahara H, Itoh T, Kudoh T, Takagi T, Shibuya K, Nomura S, Hosono M, Endo K, Konishi J.
Technetium-99m(V)dimercaptosuccinic acid uptake in intra-abdominal massive deposit of amyloid protein.
J. Nucl. Med. 34: 815-7, 1993.
[Journal]
218)  Kobayashi H, Itoh T, Murata R, Tanabe M.
Primary retroperitoneal plasmacytoma with tumor thrombus within the renal vein.
J. Urol. 147: 452-4, 1992.
[Journal]
219)  Kobayashi H, Itoh T, Murata R, Tanabe M.
Pancreatic cavernous hemangioma: CT, MRI, US, and angiography characteristics.
Gastrointest Radiol. 16: 307-10, 1991.
[Journal]
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