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Our Science – Hewitt Website

Stephen M. Hewitt, M.D., Ph.D.

Selected Publications

1)  Cho H, Kim S, Shin HY, Chung EJ, Kitano H, Hyon Park J, Park L, Chung JY, Hewitt SM, Kim JH.
Expression of stress-induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer.
Genes Chromosomes Cancer. 53: 277-88, 2014.
2)  Armani M, Tangrea M, Yang B, Rosenberg A, Ylaya K, Morris J, Rodriguez-Canales J, Hanson J, Shapiro B, Emmert-Buck MR, Smela E, Hewitt SM.
Multiplex Quantitative Measurement of mRNAs From Fixed Tissue Microarray Sections.
Diagn. Mol. Pathol. 2014.
3)  Kitano H, Chung JY, Ylaya K, Conway C, Takikita M, Fukuoka J, Doki Y, Hanaoka J, Hewitt SM.
Profiling of Phospho-AKT, Phospho-mTOR, Phospho-MAPK and EGFR in Non-small Cell Lung Cancer.
J. Histochem. Cytochem. 2014.
4)  Hembrough T, Thyparambil S, Liao WL, Darfler MM, Abdo J, Bengali KM, Hewitt SM, Bender RA, Krizman DB, Burrows J.
Application of Selected Reaction Monitoring for Multiplex Quantification of Clinically Validated Biomarkers in Formalin-Fixed, Paraffin-Embedded Tumor Tissue.
J Mol Diagn. 2013.
5)  Horne HN, Sherman ME, Garcia-Closas M, Pharoah PD, Blows FM, Yang XR, Hewitt SM, Conway CM, Lissowska J, Brinton LA, Prokunina-Olsson L, Dawson SJ, Caldas C, Easton DF, Chanock SJ, Figueroa JD.
Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression.
Breast Cancer Res. Treat. 2013.
6)  Dan T, Hewitt SM, Ohri N, Ly D, Soule BP, Smith SL, Matsuda K, Council C, Shankavaram U, Lippman ME, Mitchell JB, Camphausen K, Simone NL.
CD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up.
Breast Cancer Res. Treat. 2013.
7)  Antony S, Wu Y, Hewitt SM, Anver MR, Butcher D, Jiang G, Meitzler JL, Liu H, Juhasz A, Lu J, Roy KK, Doroshow JH.
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.
Free Radic. Biol. Med. 65C: 497-508, 2013.
8)  Camargo MC, Kim WH, Chiaravalli AM, Kim KM, Corvalan AH, Matsuo K, Yu J, Sung JJ, Herrera-Goepfert R, Meneses-Gonzalez F, Kijima Y, Natsugoe S, Liao LM, Lissowska J, Kim S, Hu N, Gonzalez CA, Yatabe Y, Koriyama C, Hewitt SM, Akiba S, Gulley ML, Taylor PR, Rabkin CS.
Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis.
Gut. 2013.
9)  Kim BW, Cho H, Chung JY, Conway C, Ylaya K, Kim JH, Hewitt SM.
Prognostic assessment of hypoxia and metabolic markers in cervical cancer using automated digital image analysis of immunohistochemistry.
J Transl Med. 11: 185, 2013.
10)  Kapanadze T, Gamrekelashvili J, Ma C, Chan C, Zhao F, Hewitt S, Zender L, Kapoor V, Felsher DW, Manns MP, Korangy F, Greten TF.
Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma.
J. Hepatol. 59: 1007-13, 2013.
11)  Keay T, Conway CM, O'Flaherty N, Hewitt SM, Shea K, Gavrielides MA.
Reproducibility in the automated quantitative assessment of HER2/neu for breast cancer.
J Pathol Inform. 4: 19, 2013.
12)  Fang C, Avis I, Bianco C, Held N, Morris J, Ylaya K, Hewitt SM, Aplin AC, Nicosia RF, Fung LA, Lewis JD, Stetler-Stevenson WG, Salomon DS, Cuttitta F.
SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells.
Open J Clin Diagn. 3: 37-51, 2013.
13)  Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo A, Hoover SB, Rodriguez-Canales J, Hewitt SM.
Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
Pigment Cell Melanoma Res. 2013.
14)  Lai JP, Liu YC, Alimchandani M, Liu Q, Aung PP, Matsuda K, Lee CC, Tsokos M, Hewitt S, Rushing EJ, Tamura D, Levens DL, Digiovanna JJ, Fine HA, Patronas N, Khan SG, Kleiner DE, Oberholtzer JC, Quezado MM, Kraemer KH.
The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D).
Acta Neuropathol Commun. 1: 4, 2013.
15)  Du Q, Yan W, Burton VH, Hewitt SM, Wang L, Hu N, Taylor PR, Armani MD, Mukherjee S, Emmert-Buck MR, Tangrea MA.
Validation of esophageal squamous cell carcinoma candidate genes from high-throughput transcriptomic studies.
Am J Cancer Res. 3: 402-10, 2013.
16)  Moore LE, Jaeger E, Nickerson ML, Brennan P, De Vries S, Roy R, Toro J, Li H, Karami S, Lenz P, Zaridze D, Janout V, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Linehan WM, Merino M, Simko J, Pfeiffer R, Boffetta P, Hewitt S, Rothman N, Chow WH, Waldman FM.
Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation.
Oncogenesis. 1: e14, 2012.
17)  Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M.
Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach.
Kidney Int. 83: 749-56, 2013.
18)  Barisoni L, Nast CC, Jennette JC, Hodgin JB, Herzenberg AM, Lemley KV, Conway CM, Kopp JB, Kretzler M, Lienczewski C, Avila-Casado C, Bagnasco S, Sethi S, Tomaszewski J, Gasim AH, Hewitt SM.
Digital Pathology Evaluation in the Multicenter Nephrotic Syndrome Study Network (NEPTUNE).
Clin J Am Soc Nephrol. [Epub ahead of print], 2013.
19)  Yang XR, Figueroa JD, Hewitt SM, Falk RT, Pfeiffer RM, Lissowska J, Peplonska B, Brinton LA, Garcia-Closas M, Sherman ME.
Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer.
Breast Cancer Res. Treat. 137: 837-47, 2013.
20)  Wu Y, Antony S, Hewitt SM, Jiang G, Yang SX, Meitzler JL, Juhasz A, Lu J, Liu H, Doroshow JH, Roy K.
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
Int. J. Oncol. 42: 1229-38, 2013.
21)  Kohaar I, Porter-Gill P, Lenz P, Fu YP, Mumy A, Tang W, Apolo AB, Rothman N, Baris D, Schned AR, Ylaya K, Schwenn M, Johnson A, Jones M, Kida M, Silverman DT, Hewitt SM, Moore LE, Prokunina-Olsson L.
Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer.
J. Natl. Cancer Inst. 105: 69-73, 2013.
22)  Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ.
Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.
Oncogene. [Epub ahead of print], 2013.
23)  Wadt K, Choi J, Chung JY, Kiilgaard J, Heegaard S, Drzewiecki KT, Trent JM, Hewitt SM, Hayward NK, Gerdes AM, Brown KM.
A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma.
Pigment Cell Melanoma Res. 25: 815-8, 2012.
24)  Chung J, Yi JM, Xie R, Brown V, Lee O, Ahuja N, Braunschweig T, Hewitt SM.
A pressure cooking-based DNA extraction from archival formalin fixed, paraffin embedded tissue.
Anal Biochem. 425: 128-34, 2012.
25)  Yang XR, Figueroa JD, Falk RT, Zhang H, Pfeiffer RM, Hewitt SM, Lissowska J, Peplonska B, Brinton L, Garcia-Closas M, Sherman ME.
Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers.
Breast Cancer Res. 14: R64, 2012.
26)  Sy MS, Altekruse SF, Li C, Lynch CF, Goodman MT, Hernandez BY, Zhou L, Saber MS, Hewitt SM, Xin W.
Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository.
Cancer Biomark. 10: 251-8, 2012.
27)  Orlov NV, Weeraratna AT, Hewitt SM, Coletta CE, Delaney JD, Mark Eckley D, Shamir L, Goldberg IG.
Automatic detection of melanoma progression by histological analysis of secondary sites.
Cytometry A. 81: 364-73, 2012.
28)  Lenz P, Pfeiffer RM, Baris D, Schned A, Takikita M, Poscablo MC, Schwenn M, Johnson AT, Jones MA, Kida M, Cantor KP, Rothman N, Silverman DT, Hewitt SM, Moore LE.
Cell Cycle Control in Urothelial Carcinoma: Large-scale Tissue Array Analysis of Tumor Tissue from Maine and Vermont.
Cancer Epidemiol Biomarkers Prev. 21: 1555-64, 2012.
29)  Levine PH, Portera CC, Hoffman HJ, Yang SX, Takikita M, Duong QN, Hewitt SM, Swain SM.
Evaluation of Lymphangiogenic Factors, Vascular Endothelial Growth Factor D and E-Cadherin in Distinguishing Inflammatory from Locally Advanced Breast Cancer.
Clin Breast Cancer. 12: 232-9, 2012.
30)  Degese MS, Mendizabal JE, Gandini NA, Gutkind JS, Molinolo A, Hewitt SM, Curino AC, Coso OA, Facchinetti MM.
Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.
Lung Cancer. 77: 168-75, 2012.
31)  Liu Q, Salaverria I, Pittaluga S, Jegalian AG, Xi L, Siebert R, Raffeld M, Hewitt SM, Jaffe ES.
Follicular Lymphomas in Children and Young Adults: A Comparison of the Pediatric Variant With Usual Follicular Lymphoma.
Am J Surg Pathol. 37: 333-43, 2012.
32)  Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy A, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D.
Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer.
Int. J. Cancer. 132: 1771-80, 2012.
33)  Lee HJ, Chung JY, Hewitt SM, Yu E, Hong SM.
HER3 overexpression is a prognostic indicator of extrahepatic cholangiocarcinoma.
Virchows Arch. 461: 521-30, 2012.
34)  Zhao F, Hoechst B, Gamrekelashvili J, Ormandy LA, Voigtländer T, Wedemeyer H, Ylaya K, Wang XW, Hewitt SM, Manns MP, Korangy F, Greten TF.
Human CCR4+CCR6+Th17 Cells Suppress Autologous CD8+ T Cell Responses.
J Immunol. 188: 6055-62, 2012.
35)  Hipp JA, Hipp JD, Lim M, Sharma G, Smith LB, Hewitt SM, Balis UG.
Image microarrays derived from tissue microarrays (IMA-TMA): New resource for computer-aided diagnostic algorithm development.
J Pathol Inform. 3: 24, 2012.
36)  Hewitt SM, Badve SS, True LD.
Impact of preanalytic factors on the design and application of integral biomarkers for directing patient therapy.
Clin. Cancer Res. 18: 1524-30, 2012.
37)  Hipp J, Monaco J, Kunju LP, Cheng J, Yagi Y, Rodriguez-Canales J, Emmert-Buck MR, Hewitt S, Feldman MD, Tomaszewski JE, Toner M, Tompkins RG, Flotte T, Lucas D, Gilbertson JR, Madabhushi A, Balis U.
Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification.
Anal Cell Pathol (Amst). 35: 251-65, 2012.
38)  Poste G, Carbone DP, Parkinson DR, Verweij J, Hewitt SM, Jessup JM.
Leveling the Playing Field: Bringing Development of Biomarkers and Molecular Diagnostics up to the Standards for Drug Development.
Clin Cancer Res. 18: 1515-1523, 2012.
39)  Molinolo AA, Marsh CA, El Dinali M, Gangane N, Jennison K, Hewitt SM, Patel V, Seiwert TY, Gutkind JS.
mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas.
Clin Cancer Res. 18: 2558-68, 2012.
40)  Noh KH, Kim BW, Song KH, Cho H, Lee YH, Kim JH, Chung JY, Kim JH, Hewitt SM, Seong SY, Mao CP, Wu TC, Kim TW.
Nanog signaling in cancer promotes stem-like phenotype and immune evasion.
J. Clin. Invest. 122: 4077-93, 2012.
41)  Chung J, Kitano H, Takikita M, Cho H, Noh KH, Kim TW, Ylaya K, Hanaoka J, Fukuoka J, Hewitt SM.
Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer.
Hum Pathol. 44: 472-9, 2012.
42)  Hewitt SM.
Tissue microarrays as a tool in the discovery and validation of predictive biomarkers.
Methods Mol. Biol. 823: 201-14, 2012.
43)  Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP.
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
J Clin Invest. 121: 880-92, 2011.
44)  Cerliani JP, Vanzulli SI, Piñero CP, Bottino MC, Sahores A, Nuñez M, Varchetta R, Martins R, Zeitlin E, Hewitt SM, Molinolo AA, Lanari C, Lamb CA.
Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer.
Breast Cancer Res Treat. 133: 997-1008, 2011.
45)  Hipp J, Cheng J, Daignault S, Sica J, Dugan MC, Lucas D, Yagi Y, Hewitt S, Balis UJ.
Automated area calculation of histopathologic features using SIVQ.
Anal Cell Pathol (Amst). 34: 265-75, 2011.
46)  Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ.
Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
J Pathol Inform. 2: 25, 2011.
47)  Gonzalez-Bosquet J, Calcei J, Wei JS, Garcia-Closas M, Sherman ME, Hewitt S, Vockley J, Lissowska J, Yang HP, Khan J, Chanock S.
Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.
PLoS ONE. 6: e14522, 2011.
48)  Burton ER, Gaffar A, Lee SJ, Adeshuko F, Whitney KD, Chung J, Hewitt SM, Huang GS, Goldberg GL, Libutti SK, Kwon M.
Down-Regulation of Filamin A Interacting Protein 1-Like Is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer.
Mol Cancer Res. 9: 1126-38, 2011.
49)  Osborne TS, Ren L, Healey JH, Shapiro LQ, Chou AJ, Gorlick RG, Hewitt SM, Khanna C.
Evaluation of eIF4E Expression in an Osteosarcoma-Specific Tissue Microarray.
J. Pediatr. Hematol. Oncol. 33: 524-8, 2011.
50)  Abedi-Ardekani B, Kamangar F, Sotoudeh M, Villar S, Islami F, Aghcheli K, Nasrollahzadeh D, Taghavi N, Dawsey SM, Abnet CC, Hewitt SM, Fahimi S, Saidi F, Brennan P, Boffetta P, Malekzadeh R, Hainaut P.
Extremely high tp53 mutation load in esophageal squamous cell carcinoma in golestan province, iran.
PLoS ONE. 6: e29488, 2011.
51)  Xie R, Chung JY, Ylaya K, Williams RL, Guerrero N, Nakatsuka N, Badie C, Hewitt SM.
Factors influencing the degradation of archival formalin-fixed paraffin-embedded tissue sections.
J. Histochem. Cytochem. 59: 356-65, 2011.
52)  Takikita M, Hu N, Shou JZ, Giffen C, Wang QH, Wang C, Hewitt SM, Taylor PR.
Fascin and CK4 as Biomarkers for Esophageal Squamous Cell Carcinoma.
Anticancer Res. 31: 945-52, 2011.
53)  Su H, Hu N, Yang HH, Wang C, Takikita M, Wang Q, Giffen C, Clifford RJ, Hewitt SM, Shou J, Goldstein AM, Lee MP, Taylor PR.
Global gene expression profiling and validation in esophageal squamous cell carcinoma (ESCC) and its association with clinical phenotypes.
Clin Cancer Res. 17: 2955-66, 2011.
54)  Eberle FC, Salaverria I, Steidl C, Summers TA, Pittaluga S, Neriah SB, Rodriguez-Canales J, Xi L, Ylaya K, Liewehr D, Dunleavy K, Wilson WH, Hewitt SM, Raffeld M, Gascoyne RD, Siebert R, Jaffe ES.
Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations.
Mod Pathol. 24: 1586-97, 2011.
55)  Hipp J, Cheng J, Pantanowitz L, Hewitt S, Yagi Y, Monaco J, Madabhushi A, Rodriguez-Canales J, Hanson J, Roy-Chowdhuri S, Filie AC, Feldman MD, Tomaszewski JE, Shih NN, Brodsky V, Giaccone G, Emmert-Buck MR, Balis UJ.
Image microarrays (IMA): Digital pathology's missing tool.
J Pathol Inform. 2: 47, 2011.
56)  Takikita M, Xie R, Chung JY, Cho H, Ylaya K, Hong SM, Moskaluk CA, Hewitt SM.
Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma.
J Transl Med. 9: 126, 2011.
57)  Eberle FC, Rodriguez-Canales J, Wei L, Hanson JC, Killian JK, Sun HW, Adams LG, Hewitt SM, Wilson WH, Pittaluga S, Meltzer PS, Staudt LM, Emmert-Buck MR, Jaffe ES.
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma.
Haematologica. 96: 558-66, 2011.
58)  Kwak JT, Hewitt SM, Sinha S, Bhargava R.
Multimodal microscopy for automated histologic analysis of prostate cancer.
BMC Cancer. 11: 62, 2011.
59)  Gavrielides MA, Gallas BD, Lenz P, Badano A, Hewitt SM.
Observer variability in the interpretation of HER2/neu immunohistochemical expression with unaided and computer-aided digital microscopy.
Arch. Pathol. Lab. Med. 135: 233-42, 2011.
60)  Hoskins E, Rodriguez-Canales J, Hewitt SM, Elmasri W, Han J, Han S, Davidson B, Kohn EC.
Paracrine SLPI secretion upregulates MMP-9 transcription and secretion in ovarian cancer cells.
Gynecol Oncol. 122: 656-62, 2011.
61)  Lipkin S, Lee J, Imagawa D, Hewitt SM, Tucker C, Zell JA, Wong V, Garcia A, Gonzalez R, Zanna GD, Richmond E, Rodriguez LM, Bigg M, Schnoll-Sussmans F, Meyskens F.
Phase IIA Trial Testing Erlotinib as an Intervention against Intraductal Pancreatic Mucinous Neoplasms.
Cancer Prev Res (Phila). 4: 512-3, 2011.
62)  Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM.
The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERalpha, and is an independent prognostic factor in node-negative breast cancer.
Oncogene. 31: 3483-94, 2011.
63)  O'Hurley G, Perry AS, O'Grady A, Loftus B, Smyth P, O'Leary JJ, Sheils O, Fitzpatrick JM, Hewitt SM, Lawler M, Kay EW.
The role of secreted frizzled-related protein 2 expression in prostate cancer.
Histopathology. 59: 1240-1248, 2011.
64)  Singh A, Mishra AK, Ylaya K, Hewitt SM, Sharma KC, Saxena S.
Wilms Tumor-1, Claudin-1 and Ezrin Are Useful Immunohistochemical Markers That Help to Distinguish Schwannoma from Fibroblastic Meningioma.
Pathol Oncol Res. 18: 383-9, 2011.
65)  Chung JY, Hewitt SM.
An optimized RNA extraction method from archival formalin-fixed paraffin-embedded tissue.
Methods Mol. Biol. 611: 19-27, 2010.
66)  Ali-Fehmi R, Chatterjee M, Ionan A, Levin NK, Arabi H, Bandyopadhyay S, Shah JP, Bryant CS, Hewitt SM, O'Rand MG, Alekseev OM, Morris R, Munkarah A, Abrams J, Tainsky MA.
Analysis of the expression of human tumor antigens in ovarian cancer tissues.
Cancer Biomark. 6: 33-48, 2010.
67)  Bolton KL, Garcia-Closas M, Pfeiffer RM, Duggan MA, Howat WJ, Hewitt SM, Yang XR, Cornelison R, Anzick SL, Meltzer P, Davis S, Lenz P, Figueroa JD, Pharoah PD, Sherman ME.
Assessment of automated image analysis of breast cancer tissue microarrays for epidemiologic studies.
Cancer Epidemiol. Biomarkers Prev. 19: 992-9, 2010.
68)  Williams R, Chung JY, Ylaya K, Whiteley G, Hewitt SM.
Characterizations and validations of novel antibodies toward translational research.
Proteomics Clin Appl. 4: 618-25, 2010.
69)  Chen QR, Song YK, Yu LR, Wei JS, Chung JY, Hewitt SM, Veenstra TD, Khan J.
Global genomic and proteomic analysis identifies biological pathways related to high-risk neuroblastoma.
J. Proteome Res. 9: 373-82, 2010.
70)  Airley R, Evans A, Mobasheri A, Hewitt SM.
Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays.
Ann. Anat. 192: 133-8, 2010.
71)  Matsuda KM, Chung JY, Hewitt SM.
Histo-proteomic profiling of formalin-fixed, paraffin-embedded tissue.
Expert Rev Proteomics. 7: 227-37, 2010.
72)  Eberle FC, Hanson JC, Killian JK, Wei L, Ylaya K, Hewitt SM, Jaffe ES, Emmert-Buck MR, Rodriguez-Canales J.
Immunoguided Laser Assisted Microdissection Techniques for DNA Methylation Analysis of Archival Tissue Specimens.
J Mol Diagn. 12: 394-401, 2010.
73)  Camilli TC, Xu M, O'Connell MP, Chien B, Frank BP, Subaran S, Indig FE, Morin PJ, Hewitt SM, Weeraratna AT.
Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.
Pigment Cell Melanoma Res. 24: 175-86, 2010.
74)  Mendoza A, Hong S, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir E, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
Modeling metastasis biology and therapy in real time in the mouse lung.
J Clin Invest. 120: 2979-88, 2010.
75)  Sherman ME, Howatt W, Blows FM, Pharoah P, Hewitt SM, Garcia-Closas M.
Molecular pathology in epidemiologic studies: a primer on key considerations.
Cancer Epidemiol. Biomarkers Prev. 19: 966-72, 2010.
76)  Shen HJ, Ylaya K, Pechhold K, Wilson A, Adem A, Hewitt SM, Libutti SK.
Multiple Endocrine Neoplasia Type 1 Deletion in Pancreatic {alpha}-Cells Leads to Development of Insulinomas in Mice.
Endocrinology. 151: 4024-30, 2010.
77)  Yoshizawa A, Fukuoka J, Shimizu S, Shilo K, Franks TJ, Hewitt SM, Fujii T, Cordon-Cardo C, Jen J, Travis WD.
Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer.
Clin. Cancer Res. 16: 240-8, 2010.
78)  Kitano H, Kageyama S, Hewitt SM, Hayashi R, Doki Y, Ozaki Y, Fujino S, Takikita M, Kubo H, Fukuoka J.
Podoplanin expression in cancerous stroma induces lymphangiogenesis and predicts lymphatic spread and patient survival.
Arch. Pathol. Lab. Med. 134: 1520-7, 2010.
79)  Abedi-Ardekani B, Kamangar F, Hewitt SM, Hainaut P, Sotoudeh M, Abnet CC, Taylor PR, Boffetta P, Malekzadeh R, Dawsey SM.
Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran.
Gut. 59: 1178-83, 2010.
80)  Chen Q, Yu L, Tsang P, Wei JS, Song YK, Cheuk A, Chung J, Hewitt SM, Veenstra TD, Khan J.
Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a.
J Proteome Res. 10: 479-87, 2010.
81)  O'Connell MP, Fiori JL, Xu M, Carter AD, Frank BP, Camilli TC, French AD, Dissanayake SK, Indig FE, Bernier M, Taub DD, Hewitt SM, Weeraratna AT.
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.
Oncogene. 29: 34-44, 2010.
82)  Takikita M, Altekruse S, Lynch CF, Goodman MT, Hernandez BY, Green M, Cozen W, Cockburn M, Sibug Saber M, Topor M, Zeruto C, Abedi-Ardekani B, Reichman ME, Hewitt SM.
Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray.
Cancer Res. 69: 2950-5, 2009.
83)  Masmoudi H, Hewitt SM, Petrick N, Myers KJ, Gavrielides MA.
Automated quantitative assessment of HER-2/neu immunohistochemical expression in breast cancer.
IEEE Trans Med Imaging. 28: 916-25, 2009.
84)  Takikita M, Hu N, Shou JZ, Wang QH, Giffen C, Taylor PR, Hewitt SM.
Biomarkers of apoptosis and survival in esophageal squamous cell carcinoma.
BMC Cancer. 9: 310, 2009.
85)  Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, Hewitt S, Triche T, Meltzer P, Khanna C.
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
BMC Genomics. 10: 625, 2009.
86)  Abdeen A, Chou AJ, Healey JH, Khanna C, Osborne TS, Hewitt SM, Kim M, Wang D, Moody K, Gorlick R.
Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.
Cancer. 115: 5243-50, 2009.
87)  Singh A, Kapur S, Chattopadhyay I, Purkayastha J, Sharma J, Mishra A, Hewitt SM, Saxena S.
Cytokeratin Immunoexpression in Esophageal Squamous Cell Carcinoma of High-risk Population in Northeast India.
Appl. Immunohistochem. Mol. Morphol. 17: 419-24, 2009.
88)  Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM.
DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer.
PLoS Med. 6: e1000068, 2009.
89)  Shen HC, Adem A, Ylaya K, Wilson A, He M, Lorang D, Hewitt SM, Pechhold K, Harlan DM, Lubensky IA, Schmidt LS, Linehan WM, Libutti SK.
Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
PLoS ONE. 4: e4897, 2009.
90)  Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, Takkikto M, Hewitt S, Lee EL, Dashwood RH, Smoot D.
Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.
Dig. Dis. Sci. 54: 2109-17, 2009.
91)  Taylor JG, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J.
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.
J. Clin. Invest. 119: 3395-407, 2009.
92)  Chattopadhyay I, Phukan R, Singh A, Vasudevan M, Purkayastha J, Hewitt S, Kataki A, Mahanta J, Kapur S, Saxena S.
Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering.
Oncol. Rep. 21: 1135-46, 2009.
93)  Buac K, Xu M, Cronin J, Weeraratna AT, Hewitt SM, Pavan WJ.
NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.
Pigment Cell Melanoma Res. 22: 773-84, 2009.
94)  Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK.
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Cancer Res. 69: 1858-66, 2009.
95)  Gheeya JS, Chen QR, Benjamin CD, Cheuk AT, Tsang P, Chung JY, Metaferia BB, Badgett TC, Johansson P, Wei JS, Hewitt SM, Khan J.
Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma.
Cancer Biol. Ther. 8: 2386-95, 2009.
96)  Almanzar G, Olkhanud PB, Bodogai M, Dell'agnola C, Baatar D, Hewitt SM, Ghimenton C, Tummala MK, Weeraratna AT, Hoek KS, Kouprina N, Larionov V, Biragyn A.
Sperm-derived SPANX-B is a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells.
Clin. Cancer Res. 15: 1954-63, 2009.
97)  Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C.
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.
Oncogene. 28: 792-802, 2009.
98)  Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM.
The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers.
PLoS ONE. 4: e6695, 2009.
99)  Chung JY, Hong SM, Choi BY, Cho H, Yu E, Hewitt SM.
The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Clin. Cancer Res. 15: 660-7, 2009.
100)  Hewitt SM.
Tissue microarrays as a tool in the discovery and validation of tumor markers.
Methods Mol. Biol. 520: 151-61, 2009.
101)  Chung JY, Hewitt SM.
Transfer and multiplex immunoblotting of a paraffin embedded tissue.
Methods Mol. Biol. 536: 139-48, 2009.
102)  Tandle A, Hanna E, Lorang D, Hajitou A, Moya CA, Pasqualini R, Arap W, Adem A, Starker E, Hewitt S, Libutti SK.
Tumor vasculature-targeted delivery of tumor necrosis factor-alpha.
Cancer. 115: 128-39, 2009.
103)  Chung JY, Lee SJ, Kris Y, Braunschweig T, Traicoff JL, Hewitt SM.
A well-based reverse-phase protein array applicable to extracts from formalin-fixed paraffin-embedded tissue.
Proteomics Clin Appl. 2: 1539-47, 2008.
104)  Brennan DJ, Rexhepaj E, O'Brien SL, McSherry E, O'Connor DP, Fagan A, Culhane AC, Higgins DG, Jirstrom K, Millikan RC, Landberg G, Duffy MJ, Hewitt SM, Gallagher WM.
Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer.
Clin. Cancer Res. 14: 2681-9, 2008.
105)  Yaziji H, Taylor CR, Goldstein NS, Dabbs DJ, Hammond EH, Hewlett B, Floyd AD, Barry TS, Martin AW, Badve S, Baehner F, Cartun RW, Eisen RN, Swanson PE, Hewitt SM, Vyberg M, Hicks DG.
Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry.
Appl. Immunohistochem. Mol. Morphol. 16: 513-20, 2008.
106)  McGough JM, Yang D, Huang S, Georgi D, Hewitt SM, Röcken C, Tänzer M, Ebert MP, Liu K.
DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
Mol. Cancer Res. 6: 1841-51, 2008.
107)  Martinez A, Pittaluga S, Rudelius M, Davies-Hill T, Sebasigari D, Fountaine TJ, Hewitt S, Jaffe ES, Raffeld M.
Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: a novel germinal center marker.
Am. J. Surg. Pathol. 32: 1190-200, 2008.
108)  Chung J, Braunschweig T, Williams R, Guerrero N, Hoffmann KM, Kwon M, Song YK, Libutti SK, Hewitt SM.
Factors in Tissue Handling and Processing That Impact RNA Obtained From Formalin-fixed, Paraffin-embedded Tissue.
J Histochem Cytochem. 56: 1033-42, 2008.
109)  Hewitt SM, Star RA.
Frozen protein arrays.
Methods Mol. Biol. 441: 105-12, 2008.
110)  Kwon M, Hanna E, Lorang D, He M, Quick JS, Adem A, Stevenson C, Chung JY, Hewitt SM, Zudaire E, Esposito D, Cuttitta F, Libutti SK.
Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy.
Cancer Res. 68: 7332-41, 2008.
111)  Ashktorab H, Dashwood RH, Dashwood MM, Zaidi SI, Hewitt SM, Green WR, Lee EL, Daremipouran M, Nouraie M, Malekzadeh R, Smoot DT.
H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.
Helicobacter. 13: 506-17, 2008.
112)  Shou JZ, Hu N, Takikita M, Roth MJ, Johnson LL, Giffen C, Wang QH, Wang C, Wang Y, Su H, Kong LH, Emmert-Buck MR, Goldstein AM, Hewitt SM, Taylor PR.
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
Cancer Epidemiol. Biomarkers Prev. 17: 1424-35, 2008.
113)  Chen T, Lee MJ, Kim YS, Lee S, Kummar S, Gutierrez M, Hewitt SM, Trepel JB, Levin IW.
Pharmacodynamic assessment of histone deacetylase inhibitors: infrared vibrational spectroscopic imaging of protein acetylation.
Anal. Chem. 80: 6390-6, 2008.
114)  Leyland-Jones BR, Ambrosone CB, Bartlett J, Ellis MJ, Enos RA, Raji A, Pins MR, Zujewski JA, Hewitt SM, Forbes JF, Abramovitz M, Braga S, Cardoso F, Harbeck N, Denkert C, Jewell SD.
Recommendations for collection and handling of specimens from group breast cancer clinical trials.
J. Clin. Oncol. 26: 5638-44, 2008.
115)  Hewitt SM, Lewis FA, Cao Y, Conrad RC, Cronin M, Danenberg KD, Goralski TJ, Langmore JP, Raja RG, Williams PM, Palma JF, Warrington JA.
Tissue handling and specimen preparation in surgical pathology: issues concerning the recovery of nucleic acids from formalin-fixed, paraffin-embedded tissue.
Arch. Pathol. Lab. Med. 132: 1929-35, 2008.
116)  Avninder S, Ylaya K, Hewitt SM.
Tissue microarray: A simple technology that has revolutionized research in pathology.
J Postgrad Med. 54: 158-62, 2008.
117)  Hewitt SM, Takikita M, Abedi-Ardekani B, Kris Y, Bexfield K, Braunschweig T, Chung JY.
Validation of proteomic-based discovery with tissue microarrays.
Proteomics Clin Appl. 2: 1460-6, 2008.
118)  Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT.
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
Cancer Res. 68: 10205-14, 2008.
119)  Jiao W, Lin H, Datta J, Braunschweig T, Chung J, Hewitt SM, Rane SG.
Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation.
Oncogene. 27: 3156-64, 2007.
120)  Whiteford CC, Bilke S, Greer BT, Chen Q, Braunschweig TA, Cenacchi N, Wei JS, Smith MA, Houghton P, Morton C, Reynolds CP, Lock R, Gorlick R, Khanna C, Thiele CJ, Takikita M, Catchpoole D, Hewitt SM, Khan J.
Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.
Cancer Res. 67: 32-40, 2007.
121)  Fukuoka J, Dracheva T, Shih JH, Hewitt SM, Fujii T, Kishor A, Mann F, Shilo K, Franks TJ, Travis WD, Jen J.
Desmoglein 3 as a prognostic factor in lung cancer.
Hum. Pathol. 38: 276-83, 2007.
122)  Yang XR, Sherman ME, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, García-Closas M.
Differences in risk factors for breast cancer molecular subtypes in a population-based study.
Cancer Epidemiol. Biomarkers Prev. 16: 439-43, 2007.
123)  Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, Raimondi AR, Jufe R, Itoiz M, Gao Y, Saranath D, Kaleebi GS, Yoo GH, Leak L, Myers EM, Shintani S, Wong D, Massey HD, Yeudall WA, Lonardo F, Ensley J, Gutkind JS.
Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.
Clin. Cancer Res. 13: 4964-73, 2007.
124)  Yang SX, Hewitt SM, Steinberg SM, Liewehr DJ, Swain SM.
Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray.
Oncol. Rep. 17: 281-7, 2007.
125)  Traicoff JL, Chung J, Braunschweig T, Mazo I, Shu Y, Ramesh A, D'Amico MW, Galperin MM, Knezevic V, Hewitt SM.
Expression of EIF3-p48/INT6, TID1 and Patched in cancer, a profiling of multiple tumor types and correlation of expression.
J Biomed Sci. 14: 395-405, 2007.
126)  Bruce B, Khanna G, Ren L, Landberg G, Jirström K, Powell C, Borczuk A, Keller ET, Wojno KJ, Meltzer P, Baird K, McClatchey A, Bretscher A, Hewitt SM, Khanna C.
Expression of the cytoskeleton linker protein ezrin in human cancers.
Clin Exp Metastasis. 24: 69-78, 2007.
127)  Evans A, Bates V, Troy H, Hewitt S, Holbeck S, Chung Y, Phillips R, Stubbs M, Griffiths J, Airley R.
Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.
Cancer Chemother Pharmacol. 61: 377-93, 2007.
128)  Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME.
Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study.
Cancer Res. 67: 10608-17, 2007.
129)  Gannot G, Tangrea MA, Richardson AM, Flaig MJ, Hewitt SM, Marcus EM, Emmert-Buck MR, Chuaqui RF.
Layered expression scanning: multiplex molecular analysis of diverse life science platforms.
Clin. Chim. Acta. 376: 9-16, 2007.
130)  Gannot G, Tangrea MA, Erickson HS, Pinto PA, Hewitt SM, Chuaqui RF, Gillespie JW, Emmert-Buck MR.
Layered peptide array for multiplex immunohistochemistry.
J Mol Diagn. 9: 297-304, 2007.
131)  Dear JW, Leelahavanichkul A, Aponte A, Hu X, Constant SL, Hewitt SM, Yuen PS, Star RA.
Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure.
Crit. Care Med. 35: 2319-28, 2007.
132)  Hewitt SM, Takikita M, Braunschweig T, Chung JY.
Promises and challenges of predictive tissue biomarkers.
Biomark Med. 1: 313-8, 2007.
133)  Braunschweig T, Kaserer K, Chung JY, Bilke S, Krizman D, Knezevic V, Hewitt SM.
Proteomic expression profiling of thyroid neoplasms.
Proteomics Clin Appl. 1: 264-71, 2007.
134)  Goldstein NS, Hewitt SM, Taylor CR, Yaziji H, Hicks DG.
Recommendations for improved standardization of immunohistochemistry.
Appl. Immunohistochem. Mol. Morphol. 15: 124-33, 2007.
135)  Tsai YC, Mendoza A, Mariano JM, Zhou M, Kostova Z, Chen B, Veenstra T, Hewitt SM, Helman LJ, Khanna C, Weissman AM.
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.
Nat. Med. 13: 1504-9, 2007.
136)  Takikita M, Chung J, Hewitt SM.
Tissue microarrays enabling high-throughput molecular pathology.
Curr Opin Biotechnol. 18: 318-25, 2007.
137)  Ashktorab H, Daremipouran M, Wilson M, Siddiqi S, Lee EL, Rakhshani N, Rakhshani N, Malekzadeh R, Johnson AC, Hewitt SM, Smoot DT.
Transactivation of the EGFR by AP-1 Is Induced by Helicobacter pylori in Gastric Cancer.
Am J Gastroenterol. 102: 2135-46, 2007.
138)  Sherman ME, Rimm DL, Yang XR, Chatterjee N, Brinton LA, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Kalaylioglu Z, Harigopal M, Charrette L, Falk RT, Richesson D, Anderson WF, Hewitt SM, García-Closas M.
Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: a population-based analysis.
Int. J. Cancer. 121: 1079-85, 2007.
139)  Chung JY, Braunschweig T, Hu N, Roth M, Traicoff JL, Wang QH, Knezevic V, Taylor PR, Hewitt SM.
A multiplex tissue immunoblotting assay for proteomic profiling: a pilot study of the normal to tumor transition of esophageal squamous cell carcinoma.
Cancer Epidemiol. Biomarkers Prev. 15: 1403-8, 2006.
140)  Zhou H, Hewitt SM, Yuen PS, Star RA.
Acute Kidney Injury Biomarkers - Needs, Present Status, and Future Promise.
Nephrol Self Assess Program. 5: 63-71, 2006.
141)  Wedam SB, Low JA, Yang SX, Chow CK, Choyke P, Danforth D, Hewitt SM, Berman A, Steinberg SM, Liewehr DJ, Plehn J, Doshi A, Thomasson D, McCarthy N, Koeppen H, Sherman M, Zujewski J, Camphausen K, Chen H, Swain SM.
Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer.
J. Clin. Oncol. 24: 769-77, 2006.
142)  Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PS, Star RA.
Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure.
Kidney Int. 70: 496-506, 2006.
143)  Yang XR, Charette LA, Garcia-Closas M, Lissowska J, Paal E, Sidawy M, Hewitt SM, Rimm DL, Sherman ME.
Construction and Validation of Tissue Microarrays of Ductal Carcinoma In Situ and Terminal Duct Lobular Units Associated With Invasive Breast Carcinoma.
Kidney Int. 15: 157-61, 2006.
144)  Tsurutani J, Fukuoka J, Tsurutani H, Shih JH, Hewitt SM, Travis WD, Jen J, Dennis PA.
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
J. Clin. Oncol. 24: 306-14, 2006.
145)  Zhu Y, Singh B, Hewitt S, Liu A, Gomez B, Wang A, Clarke R.
Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays.
Int. J. Oncol. 28: 67-76, 2006.
146)  Krishnan K, Bruce B, Hewitt S, Thomas D, Khanna C, Helman LJ.
Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway.
Clin. Exp. Metastasis. 23: 227-36, 2006.
147)  Rabinovich A, Krajewski S, Krajewska M, Shabaik A, Hewitt SM, Belongie S, Reed JC, Price JH.
Framework for parsing, visualizing and scoring tissue microarray images.
IEEE Trans Inf Technol Biomed. 10: 209-19, 2006.
148)  Bhargava R, Fernandez DC, Hewitt SM, Levin IW.
High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data.
Biochim Biophys Acta. 1758: 830-45, 2006.
149)  Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M.
Intravenously administered vitamin C as cancer therapy: three cases.
CMAJ. 174: 937-42, 2006.
150)  Becker D, Mihm MC, Hewitt SM, Sondak VK, Fountain JW, Thurin M.
Markers and tissue resources for melanoma: meeting report.
Cancer Res. 66: 10652-7, 2006.
151)  Chung JY, Braunschweig T, Hewitt SM.
Optimization of recovery of RNA from formalin-fixed, paraffin-embedded tissue.
Diagn. Mol. Pathol. 15: 229-36, 2006.
152)  Dear JW, Yasuda H, Hu X, Hieny S, Yuen PS, Hewitt SM, Sher A, Star RA.
Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis.
Kidney Int. 69: 832-6, 2006.
153)  Gills JJ, Holbeck S, Hollingshead M, Hewitt SM, Kozikowski AP, Dennis PA.
Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
Mol. Cancer Ther. 5: 713-22, 2006.
154)  Hewitt SM.
The application of tissue microarrays in the validation of microarray results.
Methods Enzymol. 410: 400-15, 2006.
155)  Elaraj DM, Weinreich DM, Varghese S, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Alexander HR.
The role of interleukin 1 in growth and metastasis of human cancer xenografts.
Clin. Cancer Res. 12: 1088-96, 2006.
156)  Wang Y, Hewitt SM, Liu S, Zhou X, Zhu H, Zhou C, Zhang G, Quan L, Bai J, Xu N.
Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours.
Br. J. Cancer. 94: 686-91, 2006.
157)  Chung J, Braunschweig T, Tuttle K, Hewitt SM.
Tissue microarrays as a platform for proteomic investigation.
J Mol Histol. 38: 123-8, 2006.
158)  Chung JY, Braunschweig T, Baibakov G, Galperin M, Ramesh A, Skacel M, Gannot G, Knezevic V, Hewitt SM.
Transfer and multiplex immunoblotting of a paraffin embedded tissue.
Proteomics. 6: 767-74, 2006.
159)  Mobasheri A, Airley R, Hewitt SM, Marples D.
Heterogeneous expression of the aquaporin 1 (AQP1) water channel in tumors of the prostate, breast, ovary, colon and lung: a study using high density multiple human tumor tissue microarrays.
Int J Oncol. 26: 1149-58, 2005.
160)  Fernandez DC, Bhargava R, Hewitt SM, Levin IW.
Infrared spectroscopic imaging for histopathologic recognition.
Nat Biotechnol. 23: 469-74, 2005.
161)  Braunschweig T, Chung JY, Hewitt SM.
Tissue microarrays: bridging the gap between research and the clinic.
Expert Rev Proteomics. 2: 325-36, 2005.
162)  Goodman MT, Hernandez BY, Hewitt S, Lynch CF, Coté TR, Frierson HF, Moskaluk CA, Killeen JL, Cozen W, Key CR, Clegg L, Reichman M, Hankey BF, Edwards B.
Tissues from population-based cancer registries: a novel approach to increasing research potential.
Hum Pathol. 36: 812-20, 2005.
163)  Hewitt S.
Fung E, eds.
Design, Construction and Use of Tissue Microarrays. In: Protein Microarrays: Methods and Protocols.
Totowa: Humana Press; 2004. p. 61-72 [Book Chapter]
164)  Huang HE, Chin SF, Ginestier C, Bardou VJ, Adélaïde J, Iyer NG, Garcia MJ, Pole JC, Callagy GM, Hewitt SM, Gullick WJ, Jacquemier J, Caldas C, Chaffanet M, Birnbaum D, Edwards PA.
A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene.
Cancer Res. 64: 6840-4, 2004.
165)  Fukuoka J, Fujii T, Shih JH, Dracheva T, Meerzaman D, Player A, Hong K, Settnek S, Gupta A, Buetow K, Hewitt S, Travis WD, Jen J.
Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.
Clin Cancer Res. 10: 4314-24, 2004.
166)  Hewitt SM.
Design, construction, and use of tissue microarrays.
Methods Mol Biol. 264: 61-72, 2004.
167)  Hewitt SM, Dear J, Star RA.
Discovery of protein biomarkers for renal diseases.
J Am Soc Nephrol. 15: 1677-89, 2004.
168)  Tan AR, Yang X, Hewitt SM, Berman A, Lepper ER, Sparreboom A, Parr AL, Figg WD, Chow C, Steinberg SM, Bacharach SL, Whatley M, Carrasquillo JA, Brahim JS, Ettenberg SA, Lipkowitz S, Swain SM.
Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor.
J Clin Oncol. 22: 3080-90, 2004.
169)  Fergenbaum JH, Garcia-Closas M, Hewitt SM, Lissowska J, Sakoda LC, Sherman ME.
Loss of antigenicity in stored sections of breast cancer tissue microarrays.
Cancer Epidemiol Biomarkers Prev. 13: 667-72, 2004.
170)  Feldman AL, Stetler-Stevenson WG, Costouros NG, Knezevic V, Baibakov G, Alexander HR, Lorang D, Hewitt SM, Seo DW, Miller MS, O'Connor S, Libutti SK.
Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism.
Cancer Res. 64: 4481-6, 2004.
171)  Braunschweig T, Chung JY, Hewitt SM.
Perspectives in tissue microarrays.
Comb Chem High Throughput Screen. 7: 575-85, 2004.
172)  Mulshine JL, Atkinson JC, Greer RO, Papadimitrakopoulou VA, Van Waes C, Rudy S, Martin JW, Steinberg SM, Liewehr DJ, Avis I, Linnoila RI, Hewitt S, Lippman SM, Frye R, Cavanaugh PF.
Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia.
Clin Cancer Res. 10: 1565-73, 2004.
173)  Rapisarda A, Zalek J, Hollingshead M, Braunschweig T, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Hewitt SM, Shoemaker RH, Melillo G.
Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts.
Cancer Res. 64: 6845-8, 2004.
174)  Erez A, Perelman M, Hewitt SM, Cojacaru G, Goldberg I, Shahar I, Yaron P, Muler I, Campaner S, Amariglio N, Rechavi G, Kirsch IR, Krupsky M, Kaminski N, Izraeli S.
Sil overexpression in lung cancer characterizes tumors with increased mitotic activity.
Oncogene. 23: 5371-7, 2004.
175)  Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, Yeung C, Gorlick R, Hewitt SM, Helman LJ.
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.
Nat Med. 10: 182-6, 2004.
176)  Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M.
Vitamin C pharmacokinetics: implications for oral and intravenous use.
Ann Intern Med. 140: 533-7, 2004.
177)  Giusti RM, Rutter JL, Duray PH, Freedman LS, Konichezky M, Fisher-Fischbein J, Greene MH, Maslansky B, Fischbein A, Gruber SB, Rennert G, Ronchetti RD, Hewitt SM, Struewing JP, Iscovich J.
A twofold increase in BRCA mutation related prostate cancer among Ashkenazi Israelis is not associated with distinctive histopathology.
J Med Genet. 40: 787-92, 2003.
178)  Finkelstein SE, Schrump DS, Nguyen DM, Hewitt SM, Kunst TF, Summers RM.
Comparative evaluation of super high-resolution CT scan and virtual bronchoscopy for the detection of tracheobronchial malignancies.
Chest. 124: 1834-40, 2003.
179)  Nishizuka S, Chen ST, Gwadry FG, Alexander J, Major SM, Scherf U, Reinhold WC, Waltham M, Charboneau L, Young L, Bussey KJ, Kim S, Lababidi S, Lee JK, Pittaluga S, Scudiero DA, Sausville EA, Munson PJ, Petricoin EF, Liotta LA, Hewitt SM, Raffeld M, Weinstein JN.
Diagnostic markers that distinguish colon and ovarian adenocarcinomas: identification by genomic, proteomic, and tissue array profiling.
Cancer Res. 63: 5243-50, 2003.
180)  Weinreich DM, Elaraj DM, Puhlmann M, Hewitt SM, Carroll NM, Feldman ED, Turner EM, Spiess PJ, Alexander HR.
Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude mice.
Cancer Res. 63: 5957-61, 2003.
181)  Miyaji T, Hu X, Yuen PS, Muramatsu Y, Iyer S, Hewitt SM, Star RA.
Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice.
Kidney Int. 64: 1620-31, 2003.
182)  Tangrea MA, Flaig MJ, Ramesh A, Best CJ, Baibakov GV, Hewitt SM, Mitchell CD, Hartmann DP, Knezevic V, Emmert-Buck MR, Chuaqui RF.
Layered expression scanning: multiplex analysis of RNA and protein gels.
Biotechniques. 35: 1280-5, 2003.
183)  Geiszt M, Lekstrom K, Brenner S, Hewitt SM, Dana R, Malech HL, Leto TL.
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes.
J Immunol. 171: 299-306, 2003.
184)  Libutti SK, Crabtree JS, Lorang D, Burns AL, Mazzanti C, Hewitt SM, O'Connor S, Ward JM, Emmert-Buck MR, Remaley A, Miller M, Turner E, Alexander HR, Arnold A, Marx SJ, Collins FS, Spiegel AM.
Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.
Cancer Res. 63: 8022-8, 2003.
185)  Kayton ML, Costouros NG, Lorang D, Alexander HR, Hewitt SM, Cochran C, Shalev A, Harlan D, Skarulis MC, Gorden P, Libutti SK.
Peak stimulated insulin secretion is associated with specific changes in gene expression profiles in sporadic insulinomas.
Surgery. 134: 982-7; discussion 987-8, 2003.
186)  Khanna C, Prehn J, Hayden D, Cassaday RD, Caylor J, Jacob S, Bose SM, Hong SH, Hewitt SM, Helman LJ.
A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy.
Clin Cancer Res. 8: 2406-12, 2002.
187)  Velasco A, Hewitt SM, Albert PS, Hossein M, Rosenberg H, Martinez C, Sagalowsky AI, McConnell JD, Marston W, Leach FS.
Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence.
Cancer. 94: 690-9, 2002.
188)  Gillespie JW, Best CJ, Bichsel VE, Cole KA, Greenhut SF, Hewitt SM, Ahram M, Gathright YB, Merino MJ, Strausberg RL, Epstein JI, Hamilton SR, Gannot G, Baibakova GV, Calvert VS, Flaig MJ, Chuaqui RF, Herring JC, Pfeifer J, Petricoin EF, Linehan WM, Duray PH, Bova GS, Emmert-Buck MR.
Evaluation of non-formalin tissue fixation for molecular profiling studies.
Am J Pathol. 160: 449-57, 2002.
189)  Miyaji T, Hewitt SM, Liotta LA, Star RA.
Frozen protein arrays: a new method for arraying and detecting recombinant and native tissue proteins.
Proteomics. 2: 1489-93, 2002.
190)  Costouros NG, Lorang D, Zhang Y, Miller MS, Diehn FE, Hewitt SM, Knopp MV, Li KC, Choyke PL, Alexander HR, Libutti SK.
Microarray gene expression analysis of murine tumor heterogeneity defined by dynamic contrast-enhanced MRI.
Mol Imaging. 1: 301-8, 2002.
191)  McCarthy NJ, Yang X, Linnoila IR, Merino MJ, Hewitt SM, Parr AL, Paik S, Steinberg SM, Hartmann DP, Mourali N, Levine PH, Swain SM.
Microvessel density, expression of estrogen receptor alpha, MIB-1, p53, and c-erbB-2 in inflammatory breast cancer.
Clin Cancer Res. 8: 3857-62, 2002.
192)  Chuaqui RF, Bonner RF, Best CJ, Gillespie JW, Flaig MJ, Hewitt SM, Phillips JL, Krizman DB, Tangrea MA, Ahram M, Linehan WM, Knezevic V, Emmert-Buck MR.
Post-analysis follow-up and validation of microarray experiments.
Nat Genet. 32 Suppl: 509-14, 2002.
193)  Pavlovich CP, Walther MM, Eyler RA, Hewitt SM, Zbar B, Linehan WM, Merino MJ.
Renal tumors in the Birt-Hogg-Dube syndrome.
Am J Surg Pathol. 26: 1542-52, 2002.
194)  Feldman AL, Friedl J, Lans TE, Libutti SK, Lorang D, Miller MS, Turner EM, Hewitt SM, Alexander HR.
Retroviral gene transfer of interferon-inducible protein 10 inhibits growth of human melanoma xenografts.
Int J Cancer. 99: 149-53, 2002.
195)  Zbar B, Alvord WG, Glenn G, Turner M, Pavlovich CP, Schmidt L, Walther M, Choyke P, Weirich G, Hewitt SM, Duray P, Gabril F, Greenberg C, Merino MJ, Toro J, Linehan WM.
Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dube syndrome.
Cancer Epidemiol Biomarkers Prev. 11: 393-400, 2002.
196)  Pautler SE, Hewitt SM, Linehan WM, Walther MM.
Specimen morcellation after laparoscopic radical nephrectomy: confirmation of histologic diagnosis using needle biopsy.
J Endourol. 16: 89-92, 2002.
197)  Schmidt LS, Warren MB, Nickerson ML, Weirich G, Matrosova V, Toro JR, Turner ML, Duray P, Merino M, Hewitt S, Pavlovich CP, Glenn G, Greenberg CR, Linehan WM, Zbar B.
Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2.
Am J Hum Genet. 69: 876-82, 2001.
198)  Feldman AL, Alexander HR, Hewitt SM, Lorang D, Thiruvathukal CE, Turner EM, Libutti SK.
Effect of retroviral endostatin gene transfer on subcutaneous and intraperitoneal growth of murine tumors.
J Natl Cancer Inst. 93: 1014-20, 2001.
199)  Deng J, Kohda Y, Chiao H, Wang Y, Hu X, Hewitt SM, Miyaji T, McLeroy P, Nibhanupudy B, Li S, Star RA.
Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury.
Kidney Int. 60: 2118-28, 2001.
200)  Poggi MM, Patronas N, Buttman JA, Hewitt SM, Fuller B.
Intramedullary spinal cord metastasis from renal cell carcinoma: detection by positron emission tomography.
Clin Nucl Med. 26: 837-9, 2001.
201)  Choyke PL, Pavlovich CP, Daryanani KD, Hewitt SM, Linehan WM, Walther MM.
Intraoperative ultrasound during renal parenchymal sparing surgery for hereditary renal cancers: a 10-year experience.
J Urol. 165: 397-400, 2001.
202)  Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T.
Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease.
Genes Chromosomes Cancer. 31: 1-9, 2001.
203)  Berger AC, Alexander HR, Tang G, Wu PS, Hewitt SM, Turner E, Kruger E, Figg WD, Grove A, Kohn E, Stern D, Libutti SK.
Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis.
Microvasc Res. 60: 70-80, 2000.
204)  Paweletz CP, Ornstein DK, Roth MJ, Bichsel VE, Gillespie JW, Calvert VS, Vocke CD, Hewitt SM, Duray PH, Herring J, Wang QH, Hu N, Linehan WM, Taylor PR, Liotta LA, Emmert-Buck MR, Petricoin EF.
Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma.
Cancer Res. 60: 6293-7, 2000.
205)  Berger AC, Feldman AL, Gnant MF, Kruger EA, Sim BK, Hewitt S, Figg WD, Alexander HR, Libutti SK.
The angiogenesis inhibitor, endostatin, does not affect murine cutaneous wound healing.
J Surg Res. 91: 26-31, 2000.
206)  Wu PC, McCart A, Hewitt SM, Turner E, Libutti SK, Bartlett DL, Alexander HR.
Isolated organ perfusion does not result in systemic microembolization of tumor cells.
Ann Surg Oncol. 6: 658-63, 1999.
207)  Saif MW, Figg WD, Hewitt S, Brosky K, Reed E, Dahut W.
Malignant ascites as only manifestation of metastatic prostate cancer.
Prostate Cancer Prostatic Dis. 2: 290-293, 1999.
208)  Abati A, Sanjuan X, Wilder A, Linehan WM, Hewitt SM, Merino MJ.
Utilization of microdissection and the polymerase chain reaction for the diagnosis of adrenal cortical carcinoma in fine-needle aspiration cytology.
Cancer. 87: 231-7, 1999.
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This page was last updated on 3/7/2014.