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Our Science – Singh Website

Shree Ram Singh, Ph.D.

Selected Publications

1)  Singh SR, Liu W, Hou SX.
The adult Drosophila malpighian tubules are maintained by multipotent stem cells.
Cell Stem Cell. 1: 191-203, 2007.
[Journal]
2)  Singh SR, Zhen W, Zheng Z, Wang H, Oh SW, Liu W, Zbar B, Schmidt LS, Hou SX.
The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance.
Oncogene. 25: 5933-41, 2006.
[Journal]
3)  Wang H, Singh SR, Zheng Z, Oh SW, Chen X, Edwards K, Hou SX.
Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis.
Dev. Cell. 10: 117-26, 2006.
[Journal]
4)  Singh SR, Zeng X, Zheng Z, Hou SX.
The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus).
Cell Cycle. 10: 1109-20, 2011.
[Journal]
5)  Singh SR, Mishra MK, Kango-Singh M, Hou SX.
Generation and staining of intestinal stem cell lineage in adult midgut.
Methods Mol. Biol. 879: 47-69, 2012.
[Journal]
6)  Wei Y, Zeng W, Wan R, Wang J, Zhou Q, Qiu S, Singh SR.
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
Eur Cell Mater. 23: 1-12, 2012.
[Journal]
7)  Singh SR, Liu Y, Kango-Singh M, Nevo E.
Genetic, immunofluorescence labeling, and in situ hybridization techniques in identification of stem cells in male and female germline niches.
Methods Mol. Biol. 1035: 9-23, 2013.
[Journal]
8)  Seol HS, Kang H, Lee SI, Kim NE, Kim TI, Chun SM, Kim TW, Yu CS, Suh YA, Singh SR, Chang S, Jang SJ.
Development and characterization of a colon PDX model that reproduces drug responsiveness and the mutation profiles of its original tumor.
Cancer Lett. 345: 56-64, 2014.
[Journal]
9)  Singh SR.
Gastric cancer stem cells: a novel therapeutic target.
Cancer Lett. 338: 110-9, 2013.
[Journal]
10)  Singh SR.
Stem cell niche in tissue homeostasis, aging and cancer.
Curr. Med. Chem. 19: 5965-74, 2012.
[Journal]
11)  Singh SR.
Cancer stem cells: recent developments and future prospects.
Cancer Lett. 338: 1-2, 2013.
[Journal]
12)  Rager S, Chan B, Forney L, Singh SR.
Role of MicroRNAs in Stem Cell Regulation and Tumorigenesis in Drosophila. In: MicroRNA in Development and in the Progression of Cancer.
New York: Springer; 2014. p. 69-80 [Book Chapter]
13)  Zeng W, Liu P, Pan W, Singh SR, Wei Y.
Hypoxia and hypoxia inducible factors in tumor metabolism.
Cancer Lett. 2014.
[Journal]
14)  Hoffmann W, Singh SR.
Editorial: stem cells in regenerative medicine and cancer.
Curr. Med. Chem. 19: 5964, 2012.
[Journal]
15)  Mishra PK, Kuypers NJ, Singh SR, Leiberh ND, Chavali V, Tyagi SC.
Cardiac stem cell niche, MMP9, and culture and differentiation of embryonic stem cells.
Methods Mol. Biol. 1035: 153-63, 2013.
[Journal]
16)  Zeng W, Wan R, Zheng Y, Singh SR, Wei Y.
Hypoxia, stem cells and bone tumor.
Cancer Lett. 313: 129-36, 2011.
[Journal]
17)  Singh SR, Burnicka-Turek O, Chauhan C, Hou SX.
Spermatogonial stem cells, infertility and testicular cancer.
J. Cell. Mol. Med. 15: 468-83, 2011.
[Journal]
18)  Singh SR, Zheng Z, Wang H, Oh SW, Chen X, Hou SX.
Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling.
J. Cell. Physiol. 223: 500-10, 2010.
[Journal]
19)  Liu W, Singh SR, Hou SX.
JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells.
J. Cell. Biochem. 109: 992-9, 2010.
[Journal]
20)  Zeng X, Singh SR, Hou D, Hou SX.
Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules.
J. Cell. Physiol. 224: 766-74, 2010.
[Journal]
21)  Mishra PK, Singh SR, Joshua IG, Tyagi SC.
Stem cells as a therapeutic target for diabetes.
Front Biosci (Landmark Ed). 15: 461-77, 2010.
[Journal]
22)  Singh UP, Singh NP, Singh B, Mishra MK, Nagarkatti M, Nagarkatti PS, Singh SR.
Stem cells as potential therapeutic targets for inflammatory bowel disease.
Front Biosci (Schol Ed). 2: 993-1008, 2010.
[Journal]
23)  Singh SR, Hou SX.
Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster.
J. Exp. Biol. 212: 413-23, 2009.
[Journal]
24)  Singh SR, Hou SX.
Immunohistological techniques for studying the Drosophila male germline stem cell.
Methods Mol. Biol. 450: 45-59, 2008.
[Journal]
25)  Hou SX, Singh SR.
Germline stem cells. Preface.
Methods Mol. Biol. 450: v, 2008.
[Journal]
26)  Singh SR, Hou SX.
Lessons learned about adult kidney stem cells from the malpighian tubules of Drosophila.
J. Am. Soc. Nephrol. 19: 660-6, 2008.
[Journal]
27)  Singh SR, Oh SW, Liu W, Chen X, Zheng Z, Hou SX.
Rap-GEF/Rap signaling restricts the formation of supernumerary spermathecae in Drosophila melanogaster.
Dev. Growth Differ. 48: 169-75, 2006.
[Journal]
28)  Singh SR, Chen X, Hou SX.
JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila.
Cell Res. 15: 1-5, 2005.
[Journal]
29)  Singh SR.
Cell Signaling and Growth Factors in Development: From Molecules to Organogenesis.
Annals of Biomedical Engineering. 37: 2660, 2009.
Full Text Article. [Journal]
30)  Singh SR.
Principles of Regenerative Medicine.
Annals of Biomedical Engineering. 37: 2658-2659, 2009.
Full Text Article. [Journal]
31)  Singh SR.
Stem Cell Transplantation: Biology, Processes, Therapy.
Annals of Biomedical Engineering,. 37: 2656-2657, 2009.
Full Text Article. [Journal]
Click Here to View Collapsed Bibliography.

This page was last updated on 6/25/2014.