Our Science – Saavedra Website
Joseph E. Saavedra, Ph.D.
Selected Publications |
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| 1)
Kiziltepe T, Hideshima T, Ishitsuka K, Ocio EM, Raje N, Catley L, Li CQ, Trudel LJ, Yasui H, Vallet S, Kutok JL, Chauhan D, Mitsiades CS, Saavedra JE, Wogan GN, Keefer LK, Shami PJ, Anderson KC. JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells. Blood. 110: 709-18, 2007. [Journal] |
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| 2)
Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines. Org. Lett. 9: 4551-4, 2007. [Journal] |
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| 3)
Qu W, Liu J, Fuquay R, Saavedra JE, Keefer LK, Waalkes MP. The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis. Cancer Lett. 256: 238-45, 2007. [Journal] |
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| 4)
Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO. Org. Lett. 9: 3409-12, 2007. [Journal] |
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| 5)
Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins. Mol. Pharmacol. 69: 501-8, 2006. [Journal] |
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| 6)
Shami PJ, Saavedra JE, Bonifant CL, Chu J, Udupi V, Malaviya S, Carr BI, Kar S, Wang M, Jia L, Ji X, Keefer LK. Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo. J. Med. Chem. 49: 4356-66, 2006. [Journal] |
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| 7)
Kong L, Saavedra JE, Buzard GS, Xu X, Hood BL, Conrads TP, Veenstra TD, Keefer LK. Deamidation of peptides in aerobic nitric oxide solution by a nitrosative pathway. Nitric Oxide. 14: 144-51, 2006. [Journal] |
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| 8)
Waterhouse DJ, Saavedra JE, Davies KM, Citro ML, Xu X, Powell DA, Grimes GJ, Potti GK, Keefer LK. Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug. Journal of pharmaceutical sciences. 95: 108-15, 2006. [Journal] |
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| 9)
Udupi V, Yu M, Malaviya S, Saavedra JE, Shami PJ. JS-K, a nitric oxide prodrug, induces cytochrome c release and caspase activation in HL-60 myeloid leukemia cells. Leuk. Res. 30: 1279-83, 2006. [Journal] |
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| 10)
Inami K, Nims RW, Srinivasan A, Citro ML, Saavedra JE, Cederbaum AI, Keefer LK. Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450. Nitric Oxide. 14: 309-15, 2006. [Journal] |
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| Click Here to View Expanded Bibliography. |
This page was last updated on 11/9/2007.
