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Our Science – Simpson Website

R. Mark Simpson, D.V.M., Ph.D.

Selected Publications

1)  Wei BR, Simpson RM.
Digital pathology and image analysis augment biospecimen annotation and biobank quality assurance harmonization.
Clin. Biochem. 47: 274-9, 2014.
2)  Ramos-Vara JA, Webster JD, Dusold D, Miller MA.
Immunohistochemical Evaluation of the Effects of Paraffin Section Storage on Biomarker Stability.
Vet. Pathol. 51: 102-9, 2014.
3)  Prieto DA, Johann DJ, Wei BR, Ye X, Chan KC, Nissley DV, Simpson RM, Citrin DE, Mackall CL, Linehan WM, Blonder J.
Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens.
Biomark Med. 8: 269-86, 2014.
4)  Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.
Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
Pigment Cell Melanoma Res. 27: 37-47, 2014.
5)  Simmons JK, Patel J, Michalowski A, Zhang S, Wei BR, Sullivan P, Gamache B, Felsenstein K, Kuehl WM, Simpson RM, Zingone A, Landgren O, Mock BA.
TORC1 and class I HDAC inhibitors synergize to suppress mature B cell neoplasms.
Mol Oncol. 8: 261-72, 2014.
6)  Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.
B Cell-Specific Deficiencies in mTOR Limit Humoral Immune Responses.
J. Immunol. 191: 1692-703, 2013.
7)  Bakhsheshian J, Wei BR, Chang KE, Shukla S, Ambudkar SV, Simpson RM, Gottesman MM, Hall MD.
Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.
Proc. Natl. Acad. Sci. U.S.A. 110: 20801-6, 2013.
8)  Risinger JI, Custer M, Feigenbaum L, Mark Simpson R, Hoover SB, Webster JD, Chandramouli GV, Tessarollo L, Barrett JC.
Normal viability of Kai1/Cd82 deficient mice.
Mol. Carcinog. [Epub ahead of print], 2013.
9)  Stuelten CH, Cervoni-Curet FN, Busch JI, Sutton E, Webster JD, Kavalukas SL, Wakefield LM, Barbul A, Niederhuber JE.
SDF-1a Mediates Wound-Promoted Tumor Growth in a Syngeneic Orthotopic Mouse Model of Breast Cancer.
PLoS ONE. 8: e60919, 2013.
10)  Zhang M, Ju W, Yao Z, Yu P, Wei B, Simpson RM, Waitz R, Fassò M, Allison JP, Waldmann TA.
Augmented IL-15Ralpha Expression by CD40 Activation Is Critical in Synergistic CD8 T Cell-Mediated Antitumor Activity of Anti-CD40 Antibody with IL-15 in TRAMP-C2 Tumors in Mice.
J Immunol. 188: 6156-64, 2012.
11)  Suh KS, Malik M, Shukla A, Ryscavage A, Wright L, Jividen K, Crutchley JM, Dumont RA, Fernandez-Salas E, Webster JD, Simpson RM, Yuspa SH.
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.
Carcinogenesis. 33: 986-95, 2012.
12)  Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM.
Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis.
J Pathol Inform. 3: 18, 2012.
13)  Cramer SD, Campbell GA, Gray CW, Lamm CG.
Pathology in practice. Brain neoplasm.
J. Am. Vet. Med. Assoc. 240: 47-9, 2012.
14)  Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J.
Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.
J. Proteome Res. 11: 1561-70, 2012.
15)  Paek SY, Miyagawa F, Zhang H, Linton JT, Hoover SB, Simpson RM, Katz SI.
Soluble peptide treatment reverses CD8 T-cell-induced disease in a mouse model of spontaneous tissue-selective autoimmunity.
J. Invest. Dermatol. 132: 677-86, 2012.
16)  Wei BR, Martin PL, Hoover SB, Spehalski E, Kumar M, Hoenerhoff MJ, Rozenberg J, Vinson C, Simpson RM.
Capacity for resolution of Ras-MAPK-initiated early pathogenic myocardial hypertrophy modeled in mice.
Comp. Med. 61: 109-18, 2011.
17)  Alsarraj J, Walker RC, Webster JD, Geiger TR, Crawford NP, Simpson RM, Ozato K, Hunter KW.
Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion.
Cancer Res. 71: 3121-31, 2011.
18)  Edwards LA, Woolard K, Son MJ, Li A, Lee J, Ene C, Mantey SA, Maric D, Song H, Belova G, Jensen RT, Zhang W, Fine HA.
Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.
J. Natl. Cancer Inst. 103: 1162-78, 2011.
19)  Morens DM, Holmes EC, Davis AS, Taubenberger JK.
Global rinderpest eradication: lessons learned and why humans should celebrate too.
J. Infect. Dis. 204: 502-5, 2011.
20)  Memoli MJ, Davis AS, Proudfoot K, Chertow DS, Hrabal RJ, Bristol T, Taubenberger JK.
Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets.
J. Infect. Dis. 203: 348-57, 2011.
21)  Cramer SD, Porter KL, Rochat MC, Lamm CG.
Pathology in practice. Liposarcoma.
J. Am. Vet. Med. Assoc. 239: 757-9, 2011.
22)  Kiupel M, Webster JD, Bailey KL, Best S, DeLay J, Detrisac CJ, Fitzgerald SD, Gamble D, Ginn PE, Goldschmidt MH, Hendrick MJ, Howerth EW, Janovitz EB, Langohr I, Lenz SD, Lipscomb TP, Miller MA, Misdorp W, Moroff S, Mullaney TP, Neyens I, O'Toole D, Ramos-Vara J, Scase TJ, Schulman FY, Sledge D, Smedley RC, Smith K, W Snyder P, Southorn E, Stedman NL, Steficek BA, Stromberg PC, Valli VE, Weisbrode SE, Yager J, Heller J, Miller R.
Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior.
Vet. Pathol. 48: 147-55, 2011.
23)  Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V, Camacho D, Simpson RM, Kelly K.
Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.
Am. J. Pathol. 179: 422-35, 2011.
24)  Hong SH, Osborne T, Ren L, Briggs J, Mazcko C, Burkett SS, Khanna C.
Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.
Vet Comp Oncol. 9: 207-18, 2011.
25)  Cramer SD, Campbell GA, Njaa BL, Morgan SE, Smith SK, McLin WR, Brodersen BW, Wise AG, Scherba G, Langohr IM, Maes RK.
Pseudorabies virus infection in Oklahoma hunting dogs.
J. Vet. Diagn. Invest. 23: 915-23, 2011.
26)  Webster JD, Simpson ER, Michalowski AM, Hoover SB, Simpson RM.
Quantifying histological features of cancer biospecimens for biobanking quality assurance using automated morphometric pattern recognition image analysis algorithms.
J Biomol Tech. 22: 108-18, 2011.
27)  Sharkey LC, Simpson RM, Wellman ML, Craig LE, Birkebak TA, Kock ND, Miller MA, Harris RK, Munson L.
The Value of Biomedical Research Training for Veterinary Anatomic and Clinical Pathologists.
Vet. Pathol. 49: 581-5, 2011.
28)  Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD.
brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
Proc. Natl. Acad. Sci. U.S.A. 107: 19350-5, 2010.
29)  Rote NS, Wei BR, Xu C, Luo L.
Caspase 8 and human villous cytotrophoblast differentiation.
Placenta. 31: 89-96, 2010.
30)  Johann DJ, Wei BR, Prieto DA, Chan KC, Ye X, Valera VA, Simpson RM, Rudnick PA, Xiao Z, Issaq HJ, Linehan WM, Stein SE, Veenstra TD, Blonder J.
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma.
Anal. Chem. 82: 1584-8, 2010.
31)  Reed LT, Miller MA, Visvesvara GS, Gardiner CH, Logan MA, Packer RA.
Diagnostic exercise. Cerebral mass in a puppy with respiratory distress and progressive neurologic signs.
Vet. Pathol. 47: 1116-9, 2010.
32)  Webster JD, Miller MA, DuSold D, Ramos-Vara J.
Effects of prolonged formalin fixation on the immunohistochemical detection of infectious agents in formalin-fixed, paraffin-embedded tissues.
Vet. Pathol. 47: 529-35, 2010.
33)  Munson L, Craig LE, Miller MA, Kock ND, Simpson RM, Wellman ML, Sharkey LC, Birkebak TA.
Elements of good training in anatomic pathology.
Vet. Pathol. 47: 995-1002, 2010.
34)  Samuel AS, Subbiah M, Shive H, Collins PL, Samal SK.
Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9.
Vet. Res. 42: 38, 2010.
35)  Song H, Mak KK, Topol L, Yun K, Hu J, Garrett L, Chen Y, Park O, Chang J, Simpson RM, Wang CY, Gao B, Jiang J, Yang Y.
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.
Proc. Natl. Acad. Sci. U.S.A. 107: 1431-6, 2010.
36)  Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE.
Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.
Cancer Res. 70: 5706-16, 2010.
37)  Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir el H, Dakir el-H, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
Modeling metastasis biology and therapy in real time in the mouse lung.
J. Clin. Invest. 120: 2979-88, 2010.
38)  Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
J. Exp. Med. 207: 1625-36, 2010.
39)  Corps KN, Islam Z, Pestka JJ, Harkema JR.
Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury.
Toxicol Pathol. 38: 429-51, 2010.
40)  Reed LT, Balog KA, Boes KM, Messick JB, Miller MA.
Pathology in practice. Granulomatous pneumonia, prostatitis and uveitis with intralesional yeasts consistent with Blastomyces.
J. Am. Vet. Med. Assoc. 236: 411-3, 2010.
41)  Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, Vail DM, Nuckolls K, Osborne T, Yalkowsy S, Gustafson D, Yu Y, Cao L, Khanna C.
Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs.
PLoS ONE. 5: e11013, 2010.
42)  Webster JD, Dennis MM, Dervisis N, Heller J, Bacon NJ, Bergman PJ, Bienzle D, Cassali G, Castagnaro M, Cullen J, Esplin DG, Peña L, Goldschmidt MH, Hahn KA, Henry CJ, Hellmén E, Kamstock D, Kirpensteijn J, Kitchell BE, Amorim RL, Lenz SD, Lipscomb TP, McEntee M, McGill LD, McKnight CA, McManus PM, Moore AS, Moore PF, Moroff SD, Nakayama H, Northrup NC, Sarli G, Scase T, Sorenmo K, Schulman FY, Shoieb AM, Smedley RC, Spangler WL, Teske E, Thamm DH, Valli VE, Vernau W, von Euler H, Withrow SJ, Weisbrode SE, Yager J, Kiupel M.
Recommended Guidelines for the Conduct and Evaluation of Prognostic Studies in Veterinary Oncology.
Vet Pathol. 48: 7-18, 2010.
43)  Aprelikova O, Yu X, Palla J, Wei BR, John S, Yi M, Stephens R, Simpson RM, Risinger JI, Jazaeri A, Niederhuber J.
The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts.
Cell Cycle. 9: 4387-98, 2010.
44)  McCalla-Martin AC, Chen X, Linder KE, Estrada JL, Piedrahita JA.
Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N.
Transgenic Res. 19: 869-87, 2010.
45)  Abdeen A, Chou AJ, Healey JH, Khanna C, Osborne TS, Hewitt SM, Kim M, Wang D, Moody K, Gorlick R.
Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.
Cancer. 115: 5243-50, 2009.
46)  Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Proc. Natl. Acad. Sci. U.S.A. 106: 14502-7, 2009.
47)  Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI, Alvord WG, Quiñones OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM, Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA, Petricoin EF, Simpson RM.
Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.
PLoS ONE. 4: e7670, 2009.
48)  Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C.
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.
Oncogene. 28: 792-802, 2009.
49)  Wei BR, Edwards JB, Hoover SB, Tillman HS, Reed LT, Sills RC, Simpson RM.
Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
Toxicol Pathol. 36: 972-80, 2008.
50)  Higgins MA, Rossmeisl JH, Saunders GK, Hayes S, Kiupel M.
B-cell lymphoma in the peripheral nerves of a cat.
Vet. Pathol. 45: 54-7, 2008.
51)  Siu IM, Bai R, Gallia GL, Edwards JB, Tyler BM, Eberhart CG, Riggins GJ.
Coexpression of neuronatin splice forms promotes medulloblastoma growth.
Neuro-oncology. 10: 716-24, 2008.
52)  Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA.
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Cancer Cell. 13: 69-80, 2008.
53)  Caudell D, Aplan PD.
The role of CALM-AF10 gene fusion in acute leukemia.
Leukemia. 22: 678-85, 2008.
54)  Caudell D, Zhang Z, Chung YJ, Aplan PD.
Expression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic mice.
Cancer Res. 67: 8022-31, 2007.
55)  Walling BE, Munasinghe J, Berrigan D, Bailey MQ, Simpson RM.
Intra-abdominal fat burden discriminated in vivo using proton magnetic resonance spectroscopy.
Obesity (Silver Spring). 15: 69-77, 2007.
56)  Beaty RM, Edwards JB, Boon K, Siu IM, Conway JE, Riggins GJ.
PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium.
J. Neurooncol. 81: 241-8, 2007.
57)  Andoh M, Zhang G, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE.
T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.
Infect. Immun. 75: 3245-55, 2007.
58)  Toubaji A, Hill S, Terabe M, Qian J, Floyd T, Simpson RM, Berzofsky JA, Khleif SN.
The combination of GM-CSF and IL-2 as local adjuvant shows synergy in enhancing peptide vaccines and provides long term tumor protection.
Vaccine. 25: 5882-91, 2007.
59)  Zarfoss MK, Klauss G, Newkirk K, Kiupel M, Jones Y, Colitz CM, Dubielzig RR.
Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.
Vet. Pathol. 44: 276-84, 2007.
60)  Custer MC, Risinger JI, Hoover S, Simpson RM, Patterson T, Barrett JC.
Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressor.
Prostate. 66: 567-77, 2006.
61)  Zhao TM, Hague B, Caudell DL, Simpson RM, Kindt TJ.
Quantification of HTLV-I proviral load in experimentally infected rabbits.
Retrovirology. 2: 34, 2005.
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This page was last updated on 5/16/2014.