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Yien Che Tsai, Ph.D.

Selected Publications

1)  Tsai Y, Moller B, Adler M, Oyler G.
Foster K, eds.
Molecular Basis for Persistence of Botulinum Neurotoxin: The Role of Intracellular Protein Degradation Pathways. In: Molecular Aspects of Botulinum Neurotoxin.
NY: Springer; 2014. p. 191-206 [Book Chapter]
2)  Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.
Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation.
PLoS ONE. 9: e92290, 2014.
3)  Tsai YC, Weissman AM.
A ubiquitin-binding rhomboid protease aimed at ERADication.
Dev. Cell. 23: 454-6, 2012.
4)  Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Mol. Biol. Cell. 23: 4484-94, 2012.
5)  Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM.
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.
Mol. Cell. 47: 547-57, 2012.
6)  Tsai YC, Weissman AM.
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
FEBS Lett. 585: 3166-73, 2011.
7)  Tsai YC, Weissman AM.
Ubiquitylation in ERAD: reversing to go forward?.
PLoS Biol. 9: e1001038, 2011.
8)  Tsai YC, Maditz R, Kuo CL, Fishman PS, Shoemaker CB, Oyler GA, Weissman AM.
Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system.
Proc. Natl. Acad. Sci. U.S.A. 107: 16554-9, 2010.
9)  Tsai YC, Weissman AM.
The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer.
Genes Cancer. 1: 764-778, 2010.
10)  Das R, Mariano J, Tsai YC, Kalathur RC, Kostova Z, Li J, Tarasov SG, McFeeters RL, Altieri AS, Ji X, Byrd RA, Weissman AM.
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Mol. Cell. 34: 674-85, 2009.
11)  Nivitchanyong T, Tsai YC, Betenbaugh MJ, Oyler GA.
An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering.
Virus Res. 141: 1-12, 2009.
12)  Martin DN, Boersma BJ, Yi M, Reimers M, Howe TM, Yfantis HG, Tsai YC, Williams EH, Lee DH, Stephens RM, Weissman AM, Ambs S.
Differences in the tumor microenvironment between African-American and European-American breast cancer patients.
PLoS ONE. 4: e4531, 2009.
13)  Shmueli A, Tsai YC, Yang M, Braun MA, Weissman AM.
Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.
Biochem. Biophys. Res. Commun. 390: 758-62, 2009.
14)  Zheng JY, Tsai YC, Kadimcherla P, Zhang R, Shi J, Oyler GA, Boustany NN.
The C-terminal transmembrane domain of Bcl-xL mediates changes in mitochondrial morphology.
Biophys. J. 94: 286-97, 2008.
15)  Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM.
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
Cancer Res. 67: 9472-81, 2007.
16)  Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM.
RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.
Oncogene. 26: 2263-71, 2007.
17)  Tsai YC, Mendoza A, Mariano JM, Zhou M, Kostova Z, Chen B, Veenstra T, Hewitt SM, Helman LJ, Khanna C, Weissman AM.
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.
Nat. Med. 13: 1504-9, 2007.
18)  Kostova Z, Tsai YC, Weissman AM.
Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.
Semin. Cell Dev. Biol. 18: 770-9, 2007.
19)  Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH.
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
Nat. Struct. Mol. Biol. 13: 264-71, 2006.
20)  Chen B, Mariano J, Tsai YC, Chan AH, Cohen M, Weissman AM.
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site.
Proc. Natl. Acad. Sci. U.S.A. 103: 341-6, 2006.
21)  Mattera R, Tsai YC, Weissman AM, Bonifacino JS.
The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.
J. Biol. Chem. 281: 6874-83, 2006.
22)  Lorick K, Tsai Y, Yang Y, Weissman A.
Mayor R, Ciechanover A, Rechsteiner M, eds.
RING fingers and relatives: Determinators of protein fate. In: Protein Degradation: Ubiquitin and the Chemistry of Life. Volume 1.
Weinheim: Wiley‐VCH Verlag GmbH & Co. KGaA; 2005. p. 44-101 [Book Chapter]
23)  Boustany NN, Tsai YC, Pfister B, Joiner WM, Oyler GA, Thakor NV.
BCL-xL-dependent light scattering by apoptotic cells.
Biophys. J. 87: 4163-71, 2004.
24)  Sherman DL, Patel CB, Zhang N, Rossell LA, Tsai YC, Thakor NV, Mirski MA.
Sinusoidal modeling of ictal activity along a thalamus-to-cortex seizure pathway I: new coherence approaches.
Ann Biomed Eng. 32: 1252-64, 2004.
25)  Mirski MA, Tsai YC, Rossell LA, Thakor NV, Sherman DL.
Anterior thalamic mediation of experimental seizures: selective EEG spectral coherence.
Epilepsia. 44: 355-65, 2003.
26)  Tsai YC, Fishman PS, Thakor NV, Oyler GA.
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.
J. Biol. Chem. 278: 22044-55, 2003.
27)  Sherman DL, Tsai YC, Rossell LA, Mirski MA, Thakor NV.
Spectral analysis of a thalamus-to-cortex seizure pathway.
IEEE Trans Biomed Eng. 44: 657-64, 1997.
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This page was last updated on 4/15/2014.