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Our Science – Tsai Website

Yien Che Tsai, Ph.D.

Selected Publications

1)  Tsai Y, Moller B, Adler M, Oyler G.
Foster K, eds.
Molecular Basis for Persistence of Botulinum Neurotoxin: The Role of Intracellular Protein Degradation Pathways. In: Molecular Aspects of Botulinum Neurotoxin.
NY: Springer; 2014. p. 191-206 [Book Chapter]
2)  Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.
Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation.
PLoS ONE. 9: e92290, 2014.
3)  Tsai YC, Weissman AM.
A ubiquitin-binding rhomboid protease aimed at ERADication.
Dev. Cell. 23: 454-6, 2012.
4)  Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Mol. Biol. Cell. 23: 4484-94, 2012.
5)  Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM.
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.
Mol. Cell. 47: 547-57, 2012.
6)  Tsai YC, Weissman AM.
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
FEBS Lett. 585: 3166-73, 2011.
7)  Tsai YC, Weissman AM.
Ubiquitylation in ERAD: reversing to go forward?.
PLoS Biol. 9: e1001038, 2011.
8)  Tsai YC, Maditz R, Kuo CL, Fishman PS, Shoemaker CB, Oyler GA, Weissman AM.
Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system.
Proc. Natl. Acad. Sci. U.S.A. 107: 16554-9, 2010.
9)  Tsai YC, Weissman AM.
The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer.
Genes Cancer. 1: 764-778, 2010.
10)  Das R, Mariano J, Tsai YC, Kalathur RC, Kostova Z, Li J, Tarasov SG, McFeeters RL, Altieri AS, Ji X, Byrd RA, Weissman AM.
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Mol. Cell. 34: 674-85, 2009.
Click Here to View Expanded Bibliography.

This page was last updated on 4/15/2014.