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Our Science – Yang Website

Howard H. Yang, Ph.D.

Selected Publications

1)  Sato M, Kadota M, Tang B, Yang HH, Yang YA, Shan M, Weng J, Welsh MA, Flanders KC, Nagano Y, Michalowski AM, Clifford RJ, Lee MP, Wakefield LM.
An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-beta in human breast cancer.
Breast Cancer Res. 16: R57, 2014.
2)  Wang G, Hu N, Yang HH, Wang L, Su H, Wang C, Clifford R, Dawsey EM, Li JM, Ding T, Han XY, Giffen C, Goldstein AM, Taylor PR, Lee MP.
Comparison of global gene expression of gastric cardia and noncardia cancers from a high-risk population in china.
PLoS ONE. 8: e63826, 2013.
3)  Di LJ, Byun JS, Wong MM, Wakano C, Taylor T, Bilke S, Baek S, Hunter K, Yang H, Lee M, Zvosec C, Khramtsova G, Cheng F, Perou CM, Miller CR, Raab R, Olopade OI, Gardner K.
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.
Nat Commun. 4: 1449, 2013.
4)  Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, Goldstein AM, Lee MP, Taylor PR.
Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes.
Clin. Cancer Res. 17: 2955-66, 2011.
5)  Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP.
Influence of genetic background and tissue types on global DNA methylation patterns.
PLoS ONE. 5: e9355, 2010.
6)  Kadota M, Yang HH, Gomez B, Sato M, Clifford RJ, Meerzaman D, Dunn BK, Wakefield LM, Lee MP.
Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines.
PLoS ONE. 5: e9201, 2010.
7)  Hu N, Clifford RJ, Yang HH, Wang C, Goldstein AM, Ding T, Taylor PR, Lee MP.
Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma.
BMC Genomics. 11: 576, 2010.
8)  Hu N, Wang C, Ng D, Clifford R, Yang HH, Tang ZZ, Wang QH, Han XY, Giffen C, Goldstein AM, Taylor PR, Lee MP.
Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China.
Cancer Res. 69: 5908-17, 2009.
9)  Kadota M, Sato M, Duncan B, Ooshima A, Yang HH, Diaz-Meyer N, Gere S, Kageyama S, Fukuoka J, Nagata T, Tsukada K, Dunn BK, Wakefield LM, Lee MP.
Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA.
Cancer Res. 69: 7357-65, 2009.
10)  Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, Lee MP, Ozato K, Hunter KW.
Bromodomain 4 activation predicts breast cancer survival.
Proc. Natl. Acad. Sci. U.S.A. 105: 6380-5, 2008.
11)  Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee MP, Goldstein AM, Taylor PR.
Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.
Int. J. Cancer. 123: 1610-5, 2008.
12)  Yang HH, Hu N, Taylor PR, Lee MP.
Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases.
Methods Mol. Med. 141: 23-35, 2008.
13)  Kadota M, Yang HH, Hu N, Wang C, Hu Y, Taylor PR, Buetow KH, Lee MP.
Allele-specific chromatin immunoprecipitation studies show genetic influence on chromatin state in human genome.
PLoS Genet. 3: e81, 2007.
14)  Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, Bauer K, Vasselli JR, Maranchie JK, Kohn KW, Buetow KH, Linehan WM, Weinstein JN, Lee MP, Klausner RD, Barrett JC.
Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.
Cancer Res. 66: 7216-24, 2006.
15)  Hu N, Wang C, Hu Y, Yang HH, Kong LH, Lu N, Su H, Wang QH, Goldstein AM, Buetow KH, Emmert-Buck MR, Taylor PR, Lee MP.
Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array.
BMC Genomics. 7: 299, 2006.
16)  Lin W, Yang HH, Lee MP.
Allelic variation in gene expression identified through computational analysis of the dbEST database.
Genomics. 86: 518-27, 2005.
17)  Lee MP, Howcroft K, Kotekar A, Yang HH, Buetow KH, Singer DS.
ATG deserts define a novel core promoter subclass.
Genome Res. 15: 1189-97, 2005.
18)  Hu N, Wang C, Hu Y, Yang HH, Giffen C, Tang ZZ, Han XY, Goldstein AM, Emmert-Buck MR, Buetow KH, Taylor PR, Lee MP.
Genome-wide association study in esophageal cancer using GeneChip mapping 10K array.
Cancer Res. 65: 2542-6, 2005.
19)  Yang HH, Hu Y, Buetow KH, Lee MP.
A computational approach to measuring coherence of gene expression in pathways.
Genomics. 84: 211-7, 2004.
20)  Yang HH, Lee MP.
Application of bioinformatics in cancer epigenetics.
Ann. N. Y. Acad. Sci. 1020: 67-76, 2004.
21)  Wang Z, Fan H, Yang HH, Hu Y, Buetow KH, Lee MP.
Comparative sequence analysis of imprinted genes between human and mouse to reveal imprinting signatures.
Genomics. 83: 395-401, 2004.
22)  Lo HS, Wang Z, Hu Y, Yang HH, Gere S, Buetow KH, Lee MP.
Allelic variation in gene expression is common in the human genome.
Genome Res. 13: 1855-62, 2003.
23)  Yang HH, Hu Y, Edmonson M, Buetow K, Lee MP.
Computation method to identify differential allelic gene expression and novel imprinted genes.
Bioinformatics. 19: 952-5, 2003.
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This page was last updated on 7/14/2014.