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Our Science – Antony Website

Smitha Antony, Ph.D.

Selected Publications

1)  Wu Y, Antony S, Juhasz A, Lu J, Ge Y, Jiang G, Roy K, Doroshow JH.
Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-{gamma} (IFN-{gamma})-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines.
J. Biol. Chem. 286: 12245-56, 2011.
[Journal]
2)  Weidlich IE, Dexheimer T, Marchand C, Antony S, Pommier Y, Nicklaus MC.
Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.
Bioorg. Med. Chem. 18: 182-9, 2010.
[Journal]
3)  Dexheimer TS, Gediya LK, Stephen AG, Weidlich I, Antony S, Marchand C, Interthal H, Nicklaus M, Fisher RJ, Njar VC, Pommier Y.
4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.
J. Med. Chem. 52: 7122-31, 2009.
[Journal]
4)  Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
EMBO J. 28: 3667-80, 2009.
[Journal]
5)  Guirouilh-Barbat J, Antony S, Pommier Y.
Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.
Mol. Cancer Ther. 8: 2007-14, 2009.
[Journal]
6)  Stevens EV, Nishizuka S, Antony S, Reimers M, Varma S, Young L, Munson PJ, Weinstein JN, Kohn EC, Pommier Y.
Predicting cisplatin and trabectedin drug sensitivity in ovarian and colon cancers.
Mol. Cancer Ther. 7: 10-8, 2008.
[Journal]
7)  Dexheimer TS, Antony S, Marchand C, Pommier Y.
Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Anticancer Agents Med Chem. 8: 381-9, 2008.
[Journal]
8)  Aune GJ, Takagi K, Sordet O, Guirouilh-Barbat J, Antony S, Bohr VA, Pommier Y.
Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.
Clin. Cancer Res. 14: 6449-55, 2008.
[Journal]
9)  Morrell A, Placzek MS, Steffen JD, Antony S, Agama K, Pommier Y, Cushman M.
Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.
J. Med. Chem. 50: 2040-8, 2007.
[Journal]
10)  Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M.
Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
J. Med. Chem. 50: 4419-30, 2007.
[Journal]
Click Here to View Expanded Bibliography.

This page was last updated on 5/18/2011.