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Our Science – Bera Website

Tapan K. Bera, Ph.D

Selected Publications

1)  Bera TK, Pastan I.
Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability.
Bioconjug. Chem. 9: 736-43, 1998.
[Journal]
2)  Bera TK, Pastan I.
Mesothelin is not required for normal mouse development or reproduction.
Mol. Cell. Biol. 20: 2902-6, 2000.
[Journal]
3)  Bera TK, Onda M, Brinkmann U, Pastan I.
A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2.
J. Mol. Biol. 281: 475-83, 1998.
[Journal]
4)  Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, Hahn Y, Lee B, Pastan I.
NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.
Proc. Natl. Acad. Sci. U.S.A. 101: 3059-64, 2004.
[Journal]
5)  Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I.
A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene.
J. Biol. Chem. 288: 12305-12, 2013.
[Journal]
6)  Huang YH, Terabe M, Pendleton CD, Stewart Khursigara D, Bera TK, Pastan I, Berzofsky JA.
Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.
PLoS ONE. 8: e64365, 2013.
[Journal]
7)  Hu X, Wei H, Xiang L, Chertov O, Wayne AS, Bera TK, Pastan I.
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.
Leuk. Res. 2013.
[Journal]
8)  Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I.
ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
PLoS ONE. 7: e38130, 2012.
[Journal]
9)  Wei H, Xiang L, Wayne AS, Chertov O, FitzGerald DJ, Bera TK, Pastan I.
Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.
Proc. Natl. Acad. Sci. U.S.A. 109: 6898-903, 2012.
[Journal]
10)  Bera TK, Walker DA, Sherins RJ, Pastan I.
POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells.
Biochem. Biophys. Res. Commun. 417: 1271-4, 2012.
[Journal]
11)  Fei Z, Bera TK, Liu X, Xiang L, Pastan I.
Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts.
J. Biol. Chem. 286: 27761-8, 2011.
[Journal]
12)  Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I.
CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis.
Oncogene. 2011.
[Journal]
13)  Raciti GA, Bera TK, Gavrilova O, Pastan I.
Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice.
Diabetologia. 2011.
[Journal]
14)  Carmona R, Cano E, Grueso E, Ruiz-Villalba A, Bera TK, Gaztambide J, Segovia JC, Muñoz-Chápuli R.
Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration.
J. Cell. Mol. Med. 15: 1200-9, 2011.
[Journal]
15)  Kawa S, Onda M, Ho M, Kreitman RJ, Bera TK, Pastan I.
The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan.
MAbs. 3: 479-86, 2011.
[Journal]
16)  Cereda V, Poole DJ, Palena C, Das S, Bera TK, Remondo C, Gulley JL, Arlen PM, Yokokawa J, Pastan I, Schlom J, Tsang KY.
New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy.
Cancer Immunol. Immunother. 59: 63-71, 2010.
[Journal]
17)  Liu XF, Bera TK, Liu LJ, Pastan I.
A primate-specific POTE-actin fusion protein plays a role in apoptosis.
Apoptosis. 14: 1237-44, 2009.
[Journal]
18)  Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK.
Non-AUG translational initiation of a short CAPC transcript generating protein isoform.
Biochem. Biophys. Res. Commun. 380: 508-13, 2009.
[Journal]
19)  Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I.
A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Proc. Natl. Acad. Sci. U.S.A. 105: 270-5, 2008.
[Journal]
20)  Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I.
Expression of POTE protein in human testis detected by novel monoclonal antibodies.
Biochem. Biophys. Res. Commun. 365: 603-8, 2008.
[Journal]
21)  Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I.
Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.
Stem Cells Dev. 17: 325-32, 2008.
[Journal]
22)  Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I.
Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.
Cancer Res. 68: 6306-12, 2008.
[Journal]
23)  Yokokawa J, Bera TK, Palena C, Cereda V, Remondo C, Gulley JL, Arlen PM, Pastan I, Schlom J, Tsang KY.
Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).
Int. J. Cancer. 121: 595-605, 2007.
[Journal]
24)  Ho M, Bera TK, Willingham MC, Onda M, Hassan R, FitzGerald D, Pastan I.
Mesothelin expression in human lung cancer.
Clin. Cancer Res. 13: 1571-5, 2007.
[Journal]
25)  Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I.
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells.
Cancer Res. 67: 1594-601, 2007.
[Journal]
26)  Das S, Ise T, Nagata S, Maeda H, Bera TK, Pastan I.
Palmitoylation of POTE family proteins for plasma membrane targeting.
Biochem. Biophys. Res. Commun. 363: 751-6, 2007.
[Journal]
27)  Kennedy PE, Bera TK, Wang QC, Gallo M, Wagner W, Lewis MG, Berger EA, Pastan I.
Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.
J. Leukoc. Biol. 80: 1175-82, 2006.
[Journal]
28)  Hahn Y, Bera TK, Pastan IH, Lee B.
Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.
Gene. 366: 238-45, 2006.
[Journal]
29)  Lee Y, Ise T, Ha D, Saint Fleur A, Hahn Y, Liu XF, Nagata S, Lee B, Bera TK, Pastan I.
Evolution and expression of chimeric POTE-actin genes in the human genome.
Proc. Natl. Acad. Sci. U.S.A. 103: 17885-90, 2006.
[Journal]
30)  Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I.
High expression of a cytokeratin-associated protein in many cancers.
Proc. Natl. Acad. Sci. U.S.A. 103: 5929-34, 2006.
[Journal]
31)  Onda M, Nagata S, Ho M, Bera TK, Hassan R, Alexander RH, Pastan I.
Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma.
Clin. Cancer Res. 12: 4225-31, 2006.
[Journal]
32)  Gubbels JA, Belisle J, Onda M, Rancourt C, Migneault M, Ho M, Bera TK, Connor J, Sathyanarayana BK, Lee B, Pastan I, Patankar MS.
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.
Mol. Cancer. 5: 50, 2006.
[Journal]
33)  Bera TK, Saint Fleur A, Lee Y, Kydd A, Hahn Y, Popescu NC, Zimonjic DB, Lee B, Pastan I.
POTE paralogs are induced and differentially expressed in many cancers.
Cancer Res. 66: 52-6, 2006.
[Journal]
34)  Bera TK, Saint Fleur A, Lee Y, Kydd A, Hahn Y, Popescu NC, Zimonjic DB, Lee B, Pastan I.
POTE paralogs are induced and differentially expressed in many cancers.
Cancer Res. 66: 52-6, 2006.
[Journal]
35)  Ho M, Hassan R, Zhang J, Wang QC, Onda M, Bera T, Pastan I.
Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients.
Clin. Cancer Res. 11: 3814-20, 2005.
[Journal]
36)  Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I.
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.
Clin. Cancer Res. 11: 5840-6, 2005.
[Journal]
37)  Soler-García AA, Maitra R, Kumar V, Ise T, Nagata S, Beers R, Bera TK, Pastan I.
The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein.
Reproduction. 129: 515-24, 2005.
[Journal]
38)  Hahn Y, Bera TK, Gehlhaus K, Kirsch IR, Pastan IH, Lee B.
Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases.
Proc. Natl. Acad. Sci. U.S.A. 101: 13257-61, 2004.
[Journal]
39)  Bera TK, Huynh N, Maeda H, Sathyanarayana BK, Lee B, Pastan I.
Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.
Gene. 337: 45-53, 2004.
[Journal]
40)  Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA.
Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells.
Cancer Res. 64: 2610-8, 2004.
[Journal]
41)  Hassan R, Bera T, Pastan I.
Mesothelin: a new target for immunotherapy.
Clin. Cancer Res. 10: 3937-42, 2004.
[Journal]
42)  Pastan I, Beers R, Bera TK.
Recombinant immunotoxins in the treatment of cancer.
Methods Mol. Biol. 248: 503-18, 2004.
[Journal]
43)  Maeda H, Nagata S, Wolfgang CD, Bratthauer GL, Bera TK, Pastan I.
The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria.
J. Biol. Chem. 279: 24561-8, 2004.
[Journal]
44)  Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B.
Cloning, molecular characterization, and expression analysis of Copine 8.
Biochem. Biophys. Res. Commun. 303: 842-7, 2003.
[Journal]
45)  Olsson P, Motegi A, Bera TK, Lee B, Pastan I.
PRAC2: a new gene expressed in human prostate and prostate cancer.
Prostate. 56: 123-30, 2003.
[Journal]
46)  Bera TK, Hahn Y, Lee B, Pastan IH.
TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates.
Biochem. Biophys. Res. Commun. 312: 1209-15, 2003.
[Journal]
47)  Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I.
MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.
Proc. Natl. Acad. Sci. U.S.A. 99: 6997-7002, 2002.
[Journal]
48)  Iavarone C, Wolfgang C, Kumar V, Duray P, Willingham M, Pastan I, Bera TK.
PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.
Mol. Cancer Ther. 1: 329-35, 2002.
[Journal]
49)  Bera TK, Maitra R, Iavarone C, Salvatore G, Kumar V, Vincent JJ, Sathyanarayana BK, Duray P, Lee BK, Pastan I.
PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach.
Proc. Natl. Acad. Sci. U.S.A. 99: 3058-63, 2002.
[Journal]
50)  Bera TK, Zimonjic DB, Popescu NC, Sathyanarayana BK, Kumar V, Lee B, Pastan I.
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.
Proc. Natl. Acad. Sci. U.S.A. 99: 16975-80, 2002.
[Journal]
51)  Bera TK, Williams-Gould J, Beers R, Chowdhury P, Pastan I.
Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer.
Mol. Cancer Ther. 1: 79-84, 2001.
[Journal]
52)  Bera TK, Bera J, Brinkmann U, Tessarollo L, Pastan I.
Cse1l is essential for early embryonic growth and development.
Mol. Cell. Biol. 21: 7020-4, 2001.
[Journal]
53)  Yerushalmi N, Keppler-Hafkemeyer A, Vasmatzis G, Liu XF, Olsson P, Bera TK, Duray P, Lee B, Pastan I.
ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues.
Gene. 265: 55-60, 2001.
[Journal]
54)  Olsson P, Bera TK, Essand M, Kumar V, Duray P, Vincent J, Lee B, Pastan I.
GDEP, a new gene differentially expressed in normal prostate and prostate cancer.
Prostate. 48: 231-41, 2001.
[Journal]
55)  Bera TK, Lee S, Salvatore G, Lee B, Pastan I.
MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer.
Mol. Med. 7: 509-16, 2001.
[Journal]
56)  Liu XF, Olsson P, Wolfgang CD, Bera TK, Duray P, Lee B, Pastan I.
PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon.
Prostate. 47: 125-31, 2001.
[Journal]
57)  Goldstein H, Pettoello-Mantovani M, Bera TK, Pastan IH, Berger EA.
Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice.
J. Infect. Dis. 181: 921-6, 2000.
[Journal]
58)  Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I.
XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.
Cancer Res. 60: 4752-5, 2000.
[Journal]
59)  Bera TK, Viner J, Brinkmann E, Pastan I.
Pharmacokinetics and antitumor activity of a bivalent disulfide-stabilized Fv immunotoxin with improved antigen binding to erbB2.
Cancer Res. 59: 4018-22, 1999.
[Journal]
60)  Brinkmann U, Brinkmann E, Bera TK, Wellmann A, Pastan I.
Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.
Genomics. 58: 41-9, 1999.
[Journal]
61)  Bera TK, Kennedy PE, Berger EA, Barbas CF, Pastan I.
Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein.
Mol. Med. 4: 384-91, 1998.
[Journal]
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This page was last updated on 7/11/2014.