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Our Science – Shaffer Website

Arthur L. Shaffer III, Ph.D.

Selected Publications

1)  Shaffer AL, Young RM, Staudt LM.
Pathogenesis of human B cell lymphomas.
Annu. Rev. Immunol. 30: 565-610, 2012.
2)  Yang Y, Shaffer AL, Emre NC, Ceribelli M, Zhang M, Wright G, Xiao W, Powell J, Platig J, Kohlhammer H, Young RM, Zhao H, Yang Y, Xu W, Buggy JJ, Balasubramanian S, Mathews LA, Shinn P, Guha R, Ferrer M, Thomas C, Waldmann TA, Staudt LM.
Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma.
Cancer Cell. 21: 723-37, 2012.
3)  Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM.
Oncogenically active MYD88 mutations in human lymphoma.
Nature. 470: 115-9, 2011.
4)  Shaffer AL, Emre NC, Lamy L, Ngo VN, Wright G, Xiao W, Powell J, Dave S, Yu X, Zhao H, Zeng Y, Chen B, Epstein J, Staudt LM.
IRF4 addiction in multiple myeloma.
Nature. 454: 226-31, 2008.
5)  Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM.
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.
Nature. 463: 88-92, 2010.
6)  Ippolito GC, Dekker JD, Wang YH, Lee BK, Shaffer AL, Lin J, Wall JK, Lee BS, Staudt LM, Liu YJ, Iyer VR, Tucker HO.
Dendritic cell fate is determined by BCL11A.
Proc. Natl. Acad. Sci. U.S.A. 2014.
7)  Lamy L, Ngo VN, Emre NC, Shaffer AL, Yang Y, Tian E, Nair V, Kruhlak MJ, Zingone A, Landgren O, Staudt LM.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Cancer Cell. 23: 435-49, 2013.
8)  Lee BS, Dekker JD, Lee BK, Iyer VR, Sleckman BP, Shaffer AL, Ippolito GC, Tucker PW.
The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.
Mol. Cell. Biol. 33: 1768-81, 2013.
9)  Valdez PA, Vithayathil PJ, Janelsins BM, Shaffer AL, Williamson PR, Datta SK.
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity. 36: 668-79, 2012.
10)  Annunziata CM, Hernandez L, Davis RE, Zingone A, Lamy L, Lam LT, Hurt EM, Shaffer AL, Kuehl WM, Staudt LM.
A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression.
Blood. 117: 2396-404, 2011.
Click Here to View Expanded Bibliography.

This page was last updated on 3/6/2014.