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Our Science – Henrich Website

Curtis J. Henrich, Ph.D.

Selected Publications

1)  Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauß TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
Biochem. Pharmacol. 88: 313-21, 2014.
2)  Devkota KP, Wilson JA, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.
Compounds from Simarouba berteroana which inhibit proliferation of NF1-defective cancer cells.
Phytochem Lett. 7: 42-45, 2014.
3)  Henrich CJ, Budhu A, Yu Z, Evans JR, Goncharova EI, Ransom TT, Wang XW, McMahon JB.
High-throughput screening for identification of inhibitors of EpCAM-dependent growth of hepatocellular carcinoma cells.
Chem Biol Drug Des. 82: 131-9, 2013.
4)  Devkota KP, Wilson J, Henrich CJ, McMahon JB, Reilly KM, Beutler JA.
Isobutylhydroxyamides from the pericarp of Nepalese Zanthoxylum armatum inhibit NF1-defective tumor cell line growth.
J. Nat. Prod. 76: 59-63, 2013.
5)  Henrich CJ, Beutler JA.
Matching the power of high throughput screening to the chemical diversity of natural products.
Nat Prod Rep. 30: 1284-98, 2013.
6)  Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase ß-TrCP1.
PLoS ONE. 7: e46567, 2012.
7)  Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR.
Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.
J. Nat. Prod. 75: 1490-4, 2012.
8)  Whitson EL, Sun H, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, Griesinger C, McKee TC.
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima.
J. Nat. Prod. 75: 394-9, 2012.
9)  Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA.
Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers.
J. Org. Chem. 76: 8944-54, 2011.
10)  Henrich CJ, Thomas CL, Brooks AD, Booth NL, Lowery EM, Pompei RJ, McMahon JB, Sayers TJ.
Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.
Apoptosis : an international journal on programmed cell death. 2011.
11)  Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B.
Actinopolysporins A-C and Tubercidin as a Pdcd4 Stabilizer from the Halophilic Actinomycete Actinopolyspora erythraea YIM 90600.
Journal of natural products. 2011.
12)  Grkovic T, Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR.
Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.
J. Nat. Prod. 74: 1015-20, 2011.
13)  Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR.
Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.
J. Nat. Prod. 74: 262-6, 2011.
14)  Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC.
Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula.
J. Nat. Prod. 74: 1686-91, 2011.
15)  Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA.
Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
J. Nat. Prod. 74: 374-7, 2011.
16)  Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR.
Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
Bioorg. Med. Chem. Lett. 21: 4397-9, 2011.
17)  Blees JS, Schmid T, Thomas CL, Baker AR, Benson L, Evans JR, Goncharova EI, Colburn NH, McMahon JB, Henrich CJ.
Development of a high-throughput cell-based reporter assay to identify stabilizers of tumor suppressor Pdcd4.
J Biomol Screen. 15: 21-9, 2010.
18)  Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
Bioorg. Med. Chem. Lett. 20: 3848-50, 2010.
19)  Takada K, Imamura N, Gustafson KR, Henrich CJ.
Synthesis and structure-activity relationship of botryllamides that block the ABCG2 multidrug transporter.
Bioorg. Med. Chem. Lett. 20: 1330-3, 2010.
20)  Whitson EL, Thomas CL, Henrich CJ, Sayers TJ, McMahon JB, McKee TC.
Clerodane Diterpenes from Casearia arguta That Act As Synergistic TRAIL Sensitizers.
J. Nat. Prod. 73: 2013-8, 2010.
21)  Henrich CJ, Robey RW, Takada K, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, McMahon JB, Gustafson KR.
Botryllamides: Natural Product Inhibitors of ABCG2.
ACS Chem. Biol. 4: 637-47, 2009.
22)  Kang M, Henrich CJ, Bokesch HR, Gustafson KR, McMahon JB, Baker AR, Young MR, Colburn NH.
A selective small-molecule nuclear factor-{kappa}B inhibitor from a high-throughput cell-based assay for AP-1 hits.
Mol. Cancer Ther. 8: 571-81, 2009.
23)  Booth NL, Sayers TJ, Brooks AD, Thomas CL, Jacobsen K, Goncharova EI, McMahon JB, Henrich CJ.
A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.
Cancer Immunol. Immunother. 58: 1229-44, 2009.
24)  Beutler JA, Kang M, Robert F, Clement JA, Pelletier J, Colburn NH, McKee TC, Goncharova E, McMahon JB, Henrich CJ.
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
J. Nat. Prod. 72: 503-6, 2009.
25)  Ruocco KM, Goncharova EI, Young MR, Colburn NH, McMahon JB, Henrich CJ.
A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 12: 133-9, 2007.
26)  Henrich CJ, Robey RW, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, Dean M, McMahon JB.
New inhibitors of ABCG2 identified by high-throughput screening.
Mol. Cancer Ther. 6: 3271-8, 2007.
27)  Henrich CJ, Goncharova EI, Wilson JA, Gardella RS, Johnson TR, McMahon JB, Takada K, Bokesch HR, Gustafson KR.
Natural products active in aberrant c-Kit signaling.
Chemical biology & drug design. 69: 321-30, 2007.
28)  Henrich CJ, Bokesch HR, Dean M, Bates SE, Robey RW, Goncharova EI, Wilson JA, McMahon JB.
A high-throughput cell-based assay for inhibitors of ABCG2 activity.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 11: 176-83, 2006.
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This page was last updated on 3/31/2014.