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Our Science – Reinhold Website

William C. Reinhold, B.S.

Selected Publications

1)  Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J, Pommier Y.
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.
Cancer Res. 72: 3499-511, 2012.
2)  Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.
Multifactorial regulation of E-cadherin expression: an integrative study.
Mol. Cancer Ther. 9: 1-16, 2010.
3)  Reinhold WC, Mergny JL, Liu H, Ryan M, Pfister TD, Kinders R, Parchment R, Doroshow J, Weinstein JN, Pommier Y.
Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron.
Cancer Res. 70: 2191-203, 2010.
4)  Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y.
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Proc. Natl. Acad. Sci. U.S.A. 109: 15030-5, 2012.
5)  Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology.
Cancer Res. 73: 4372-82, 2013.
6)  Kohn KW, Zeeberg BM, Reinhold WC, Pommier Y.
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype.
PLoS ONE. 9: e99269, 2014.
7)  Varma S, Pommier Y, Sunshine M, Weinstein JN, Reinhold WC.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE. 9: e92047, 2014.
8)  Reinhold WC, Varma S, Sousa F, Sunshine M, Abaan OD, Davis SR, Reinhold SW, Kohn KW, Morris J, Meltzer PS, Doroshow JH, Pommier Y.
NCI-60 Whole Exome Sequencing and Pharmacological CellMiner Analyses.
PLoS ONE. 9: e101670, 2014.
9)  Giovinazzi S, Sirleto P, Aksenova V, Morozov VM, Zori R, Reinhold WC, Ishov AM.
Usp7 protects genomic stability by regulating Bub3.
Oncotarget. 5: 3728-42, 2014.
10)  Reinhold WC.
Commentary on "MelanomaDB: a web tool for integrative analysis of melanoma genomic information to identify disease-associated molecular pathways".
Front Genet. 4: 156, 2013.
11)  Jung HM, Patel RS, Phillips BL, Wang H, Cohen DM, Reinhold WC, Chang LJ, Yang LJ, Chan EK.
Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.
Mol. Biol. Cell. 24: 1638-48, S1-7, 2013.
12)  Giovinazzi S, Morozov VM, Summers MK, Reinhold WC, Ishov AM.
USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.
Cell Death Differ. 20: 721-31, 2013.
13)  Zoppoli G, Solier S, Reinhold WC, Liu H, Connelly JW, Monks A, Shoemaker RH, Abaan OD, Davis SR, Meltzer PS, Doroshow JH, Pommier Y.
CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.
Oncogene. 31: 403-18, 2012.
14)  Zeeberg BR, Kohn KW, Kahn A, Larionov V, Weinstein JN, Reinhold W, Pommier Y.
Concordance of gene expression and functional correlation patterns across the NCI-60 cell lines and the Cancer Genome Atlas glioblastoma samples.
PLoS ONE. 7: e40062, 2012.
15)  Schowalter RM, Reinhold WC, Buck CB.
Entry Tropism of BK and Merkel Cell Polyomaviruses in Cell Culture.
PLoS ONE. 7: e42181, 2012.
16)  Kouprina N, Lee NC, Pavlicek A, Samoshkin A, Kim JH, Lee HS, Varma S, Reinhold WC, Otstot J, Solomon G, Davis S, Meltzer PS, Schleutker J, Larionov V.
Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.
Genes Chromosomes Cancer. 51: 933-48, 2012.
17)  Zeeberg BR, Reinhold W, Snajder R, Thallinger GG, Weinstein JN, Kohn KW, Pommier Y.
Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines.
PLoS ONE. 7: e30317, 2012.
18)  Kohn KW, Zeeberg BR, Reinhold WC, Sunshine M, Luna A, Pommier Y.
Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes.
PLoS ONE. 7: e35716, 2012.
19)  Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, Zheng W, Liu P.
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proc. Natl. Acad. Sci. U.S.A. 109: 14592-7, 2012.
20)  Ruan X, Kocher JP, Pommier Y, Liu H, Reinhold WC.
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap Trios, and relation to fragile site location.
PLoS ONE. 7: e31628, 2012.
21)  Zoppoli G, Douarre C, Dalla Rosa I, Liu H, Reinhold W, Pommier Y.
Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.
Nucleic Acids Res. 39: 6620-32, 2011.
22)  Eddy J, Vallur AC, Varma S, Liu H, Reinhold WC, Pommier Y, Maizels N.
G4 motifs correlate with promoter-proximal transcriptional pausing in human genes.
Nucleic Acids Res. 39: 4975-83, 2011.
23)  Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI.
Genome-wide depletion of replication initiation events in highly transcribed regions.
Genome Res. 21: 1822-32, 2011.
24)  Reinhold WC, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V.
Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability.
PLoS ONE. 6: e25991, 2011.
25)  Chen CF, He X, Arslan AD, Mo YY, Reinhold WC, Pommier Y, Beck WT.
Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness.
Mol. Pharmacol. 79: 735-41, 2011.
26)  Zeeberg BR, Liu H, Kahn AB, Ehler M, Rajapakse VN, Bonner RF, Brown JD, Brooks BP, Larionov VL, Reinhold W, Weinstein JN, Pommier YG.
RedundancyMiner: De-replication of redundant GO categories in microarray and proteomics analysis.
BMC Bioinformatics. 12: 52, 2011.
27)  Gmeiner WH, Reinhold WC, Pommier Y.
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Mol. Cancer Ther. 9: 3105-14, 2010.
28)  Liu H, D'Andrade P, Fulmer-Smentek S, Lorenzi P, Kohn KW, Weinstein JN, Pommier Y, Reinhold WC.
mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities.
Mol. Cancer Ther. 9: 1080-91, 2010.
29)  Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H, Kolbe L, Hearing VJ.
Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB.
J. Invest. Dermatol. 130: 1685-96, 2010.
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This page was last updated on 7/20/2014.