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Our Science – Gildersleeve Website

Jeffrey C. Gildersleeve, Ph.D.

Selected Publications

1)  Yin Z, Comellas-Aragones M, Chowdhury S, Bentley P, Kaczanowska K, Benmohamed L, Gildersleeve JC, Finn MG, Huang X.
Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qß Capsids.
ACS Chem. Biol. 8: 1253-62, 2013.
[Journal]
2)  Campbell CT, Llewellyn SR, Damberg T, Morgan IL, Robert-Guroff M, Gildersleeve JC.
High-Throughput Profiling of Anti-Glycan Humoral Responses to SIV Vaccination and Challenge.
PLoS ONE. 8: e75302, 2013.
[Journal]
3)  Park S, Gildersleeve JC, Blixt O, Shin I.
Carbohydrate microarrays.
Chem Soc Rev. 42: 4310-26, 2013.
[Journal]
4)  Zhang Y, Muthana SM, Farnsworth D, Ludek O, Adams K, Barchi JJ, Gildersleeve JC.
Enhanced epimerization of glycosylated amino acids during solid-phase Peptide synthesis.
J. Am. Chem. Soc. 134: 6316-25, 2012.
[Journal]
5)  Zhang Y, Li Q, Rodriguez LG, Gildersleeve JC.
An array-based method to identify multivalent inhibitors.
J. Am. Chem. Soc. 132(28): 9653-62, 2010.
[Journal]
6)  Campbell CT, Llewellyn SR, Demberg T, Morgan IL, Robert-Guroff M, Gildersleeve JC.
Correction: High-Throughput Profiling of Anti-Glycan Humoral Responses to SIV Vaccination and Challenge.
PLoS ONE. 8, 2013.
[Journal]
7)  Rho J, Mead JR, Wright WS, Brenner DE, Stave JW, Gildersleeve JC, Lampe PD.
Discovery of sialyl Lewis A and Lewis X modified protein cancer biomarkers using high density antibody arrays.
J Proteomics. 96: 291-9, 2014.
[Journal]
8)  Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, Barchi JJ, Gildersleeve JC, Pancer Z, Mariuzza RA.
Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J. Biol. Chem. 288: 23597-606, 2013.
[Journal]
9)  Campbell CT, Gulley JL, Oyelaran O, Hodge JW, Schlom J, Gildersleeve JC.
Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF.
Clin. Cancer Res. 19: 1290-9, 2013.
[Journal]
10)  Hong X, Ma MZ, Gildersleeve JC, Chowdhury S, Barchi JJ, Mariuzza RA, Murphy MB, Mao L, Pancer Z.
Sugar-binding proteins from fish: selection of high affinity "lambodies" that recognize biomedically relevant glycans.
ACS Chem. Biol. 8: 152-60, 2013.
[Journal]
11)  Bayer H, Essig K, Stanzel S, Frank M, Gildersleeve JC, Berger MR, Voss C.
Evaluation of riproximin binding properties reveals a novel mechanism for cellular targeting.
J. Biol. Chem. 287: 35873-86, 2012.
[Journal]
12)  Gildersleeve JC, Wang B, Achilefu S, Tu Z, Xu M.
Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies.
Bioorg. Med. Chem. Lett. 22: 6839-43, 2012.
[Journal]
13)  Yin Z, Nguyen HG, Chowdhury S, Bentley P, Bruckman MA, Miermont A, Gildersleeve JC, Wang Q, Huang X.
Tobacco mosaic virus as a new carrier for tumor associated carbohydrate antigens.
Bioconjug. Chem. 23: 1694-703, 2012.
[Journal]
14)  Zhang Y, Muthana SM, Barchi JJ, Gildersleeve JC.
Divergent behavior of glycosylated threonine and serine derivatives in solid phase Peptide synthesis.
Org. Lett. 14: 3958-61, 2012.
[Journal]
15)  Zhang Y, Gildersleeve JC.
General procedure for the synthesis of neoglycoproteins and immobilization on epoxide-modified glass slides.
Methods Mol. Biol. 808: 155-65, 2012.
[Journal]
16)  Gildersleeve JC.
Glycosyltransferases: Carb loading strategy is spot on.
Nat. Chem. Biol. 8: 741-2, 2012.
[Journal]
17)  Muthana SM, Campbell CT, Gildersleeve JC.
Modifications of glycans: biological significance and therapeutic opportunities.
ACS Chem. Biol. 7: 31-43, 2012.
[Journal]
18)  Shoreibah MG, Jackson C, Price PW, Meagher R, Godwin AK, Cai Q, Gildersleeve JC.
anti-hESC mAb Hesca-2 binds to a glycan epitope commonly found on carcinomas.
Stem Cells Dev. 20: 515-25, 2011.
[Journal]
19)  Zhang Y, Campbell C, Li Q, Gildersleeve JC.
Multidimensional glycan arrays for enhanced antibody profiling.
Mol Biosyst. 6(9): 1583-91, 2010.
[Journal]
20)  McCann TE, Kosaka N, Mitsunaga M, Choyke PL, Gildersleeve JC, Kobayashi H.
Biodistribution and Excretion of Monosaccharide-Albumin Conjugates Measured with in Vivo Near-Infrared Fluorescence Imaging.
Bioconjug Chem. 21(10): 1925-32, 2010.
[Journal]
21)  Li Q, Rodriguez LG, Farnsworth DF, Gildersleeve JC.
Effects of hapten density on the induced antibody repertoire.
Chembiochem. 11(12): 1686-91, 2010.
[Journal]
22)  Oyelaran O, Gildersleeve JC.
Evaluation of human antibody responses to keyhole limpet hemocyanin on a carbohydrate microarray.
Proteomics Clin Appl. 4(3): 285-294, 2010.
[Journal]
23)  Li Q, Anver MR, Li Z, Butcher DO, Gildersleeve JC.
GalNAcalpha1-3Gal, a new prognostic marker for cervical cancer.
Int. J. Cancer. 126(2): 459-68, 2010.
[Journal]
24)  Campbell C, Zhang Y, Gildersleeve J.
Construction and Use of Glycan Microarrays.
Curr. Protocols. Chem. Biol. 2: 37-53, 2010.
[Journal]
25)  Xu M, Wang F, Gildersleeve JC, Achilefu S.
MAb L9E10 to blood group H2 antigen binds to colon cancer stem cells and inhibits tumor cell migration and invasion.
Hybridoma (Larchmt). 29(4): 355-9, 2010.
[Journal]
26)  Ludek OR, Gu W, Gildersleeve JC.
Activation of glycosyl trichloroacetimidates with perchloric acid on silica (HClO(4)-SiO(2)) provides enhanced alpha-selectivity.
Carbohydr Res. 345(14): 2074-8, 2010.
[Journal]
27)  Wang Y, Gildersleeve JC, Basu A, Zimmt MB.
Photo- and Biophysical Studies of Lectin-Conjugated Fluorescent Nanoparticles: Reduced Sensitivity in High Density Assays (dagger).
J Phys Chem B. 114(45): 14487-94, 2010.
[Journal]
28)  Oyelaran O, Gildersleeve JC.
Glycan arrays: recent advances and future challenges.
Curr Opin Chem Biol. 13: 406-13, 2009.
[Journal]
29)  Oyelaran O, Li Q, Farnsworth DW, Gildersleeve JC.
Microarrays with Varying Carbohydrate Density Reveal Distinct Subpopulations of Serum Antibodies.
J. Proteome Res. 8: 3529-38, 2009.
[Journal]
30)  Oyelaran O, McShane LM, Dodd L, Gildersleeve JC.
Profiling Human Serum Antibodies with a Carbohydrate Antigen Microarray.
J. Proteome Res. 8: 4301-10, 2009.
[Journal]
31)  Li Q, Anver MR, Butcher DO, Gildersleeve JC.
Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines.
Mol. Cancer Ther. 8: 971-9, 2009.
[Journal]
32)  Hsu KL, Gildersleeve JC, Mahal LK.
A simple strategy for the creation of a recombinant lectin microarray.
Mol Biosyst. 4: 654-62, 2008.
[Journal]
33)  Gildersleeve JC, Oyelaran O, Simpson JT, Allred B.
Improved procedure for direct coupling of carbohydrates to proteins via reductive amination.
Bioconjug. Chem. 19: 1485-90, 2008.
[Journal]
34)  Manimala JC, Roach TA, Li Z, Gildersleeve JC.
Supplier-dependent anti-glycan monoclonal antibody specificities: Comment on.
Glycobiology. 18: 746, 2008.
[Journal]
35)  Li Z, Gildersleeve JC.
An armed-disarmed approach for blocking aglycon transfer of thioglycosides.
Tetrahedron Lett. 48: 559-562, 2007.
[Journal]
36)  Oyelaran O, Gildersleeve JC.
Application of carbohydrate array technology to antigen discovery and vaccine development.
Expert Rev Vaccines. 6: 957-69, 2007.
[Journal]
37)  Manimala JC, Roach TA, Li Z, Gildersleeve JC.
High-Throughput Carbohydrate Microarray Profiling of 27 Antibodies Demonstrates Widespread Specificity Problems.
Glycobiology. 2007.
[Journal]
38)  Manimala JC, Roach TA, Li Z, Gildersleeve JC.
High-Throughput Carbohydrate Microarray Analysis of 24 Lectins.
Angew Chem Int Ed Engl. 2006.
[Journal]
39)  Li Z, Gildersleeve JC.
Mechanistic studies and methods to prevent aglycon transfer of thioglycosides.
J. Am. Chem. Soc. 128: 11612-9, 2006.
[Journal]
40)  Manimala JC, Li Z, Jain A, VedBrat S, Gildersleeve JC.
Carbohydrate Array Analysis of Anti-Tn Antibodies and Lectins Reveals Unexpected Specificities: Implications for Diagnostic and Vaccine Development.
Chembiochem. 6: 2229-2241, 2005.
[Journal]
41)  Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO.
Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn.
Cancer Immunol Immunother. 54: 424-30, 2005.
[Journal]
42)  Zhang Z, Gildersleeve J, Yang YY, Xu R, Loo JA, Uryu S, Wong CH, Schultz PG.
A new strategy for the synthesis of glycoproteins.
Science. 303: 371-3, 2004.
[Journal]
43)  Gildersleeve J, Varvak A, Atwell S, Evans D, Schultz PG.
Development of a High-Throughput Screen for Protein Catalysts: Application to the Directed Evolution of Antibody Aldolases.
Angew Chem Int Ed Engl. 42: 5971-5973, 2003.
[Journal]
44)  Gildersleeve J, Janes J, Ulrich H, Yang P, Barbas C, Schultz PG.
Development of a genetic selection for catalytic antibodies.
Bioorg Med Chem Lett. 12: 1691-4, 2002.
[Journal]
45)  Xuereb H, Maletic A, Gildersleeve J, Pelczer I, Kahn D.
Design of an Oligosaccharide Scaffold that Binds in the Minor Groove of DNA.
J. Am. Chem. Soc. 122: 1883-1890, 2000.
[Journal]
46)  Gildersleeve J, Smith A, Sakurai K, Raghavan S, K D.
Scavenging Byproducts in the Sulfoxide Glycosylation Reaction: Application to the Synthesis of Ciclamycin 0.
J. Am. Chem. Soc. 121: 6176-6182, 1999.
[Journal]
47)  Gildersleeve J, Pascal R, Kahn D.
Sulfenate Intermediates in the Sulfoxide Glycosylation Reaction.
J. Am. Chem. Soc. 120: 5961-5969, 1998.
[Journal]
48)  Liang R, Yan L, Loebach J, Ge M, Uozumi Y, Sekanina K, Horan N, Gildersleeve J, Thompson C, Smith A, Biswas K, Still WC, Kahne D.
Parallel synthesis and screening of a solid phase carbohydrate library.
Science. 274: 1520-2, 1996.
[Journal]
49)  Wang L, Cummings RD, Smith DF, Huflejt M, Campbell CT, Gildersleeve JC, Gerlach JQ, Kilcoyne M, Joshi L, Serna S, Reichardt N, Parera Pera N, Pieters RJ, Eng W, Mahal LK.
Cross-platform comparison of glycan microarray formats.
Glycobiology. [Epub ahead of print], 2014.
[Journal]
50)  Muthana SM, Gildersleeve JC.
Glycan microarrays: Powerful tools for biomarker discovery.
Cancer Biomark. 14: 29-41, 2014.
[Journal]
51)  Campbell CT, Gulley JL, Oyelaran O, Hodge JW, Schlom J, Gildersleeve JC.
Humoral response to a viral glycan correlates with survival on PROSTVAC-VF.
Proc. Natl. Acad. Sci. U.S.A. [Epub ahead of print], 2014.
[Journal]
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This page was last updated on 4/28/2014.