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Our Science – Rausch Website

Jason W. Rausch, Ph.D.

Selected Publications

1)  Rausch J.
Le Grice S, Goette M, eds.
Progress towards developing potent and specific inhibitors of HIV RT-associated ribonuclease H. In: Human Immunodeficiency Virus Reverse Transcriptase: A Bench-to-Bedside Success.
New York: Springer Publishing; 2013. p. 143-172 [Book Chapter]
2)  Fang X, Wang J, O'Carroll IP, Mitchell M, Zuo X, Wang Y, Yu P, Liu Y, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans RE, Watts NR, Stahl SJ, Wingfield PT, Byrd RA, Le Grice SF, Rein A, Wang Y.
An Unusual Topological Structure of the HIV-1 Rev Response Element.
Cell. 155: 594-605, 2013.
Full Text Article. [Journal]
3)  Lusvarghi S, Sztuba-Solinska J, Purzycka KJ, Pauly GT, Rausch JW, Grice SF.
The HIV-2 Rev-response element: determining secondary structure and defining folding intermediates.
Nucleic Acids Res. 41: 6637-49, 2013.
4)  Rausch JW, Chelico L, Goodman MF, Le Grice SF.
Dissecting APOBEC3G substrate specificity by nucleoside analog interference.
J. Biol. Chem. 284: 7047-58, 2009.
5)  Abbondanzieri EA, Bokinsky G, Rausch JW, Zhang JX, Le Grice SF, Zhuang X.
Dynamic binding orientations direct activity of HIV reverse transcriptase.
Nature. 453: 184-9, 2008.
6)  Masaoka T, Chung S, Caboni P, Rausch J, Wilson JA, Taskent-Sezgin H, Beutler JA, Tocco G, Le Grice SF.
Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J. Med. Chem. 56: 5436-45, 2013.
7)  Lusvarghi S, Stuba-Solinska J, Purzycka K, Rausch J, Le Grice S.
RNA secondary structure prediction using high-throughput SHAPE.
J Vis Exp. 75: e50243, 2013.
Full Text Article. [Journal]
8)  Nowak E, Potrzebowski W, Konarev PV, Rausch JW, Bona MK, Svergun DI, Bujnicki JM, Le Grice SF, Nowotny M.
Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid.
Nucleic Acids Res. 41: 3874-3887, 2013.
Full Text Article. [Journal]
9)  Sztuba-Solinska J, Teramoto T, Rausch JW, Shapiro BA, Padmanabhan R, Le Grice SF.
Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome.
Nucleic Acids Res. 41: 5075-89, 2013.
Full Text Article. [Journal]
10)  Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF.
Synthesis, activity, and structural analysis of novel a-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J. Med. Chem. 54: 4462-73, 2011.
11)  Chung S, Rausch J, Le Grice S.
Targeting HIV reverse transcriptase-associated ribonuclease H function (19th International Conference on AIDS, Cancer and Public Health).
Kozlov A, eds.
. p. (). [Meeting Proceeding]
12)  Rausch J, Abbondanzieri E, Liu S, Zhuang X, Le Grice S.
Lever A, Jeang K, Berkhout B, eds.
Retrovirus replication: New perspectives on enzyme and substrate dynamics. In: Recent Advances in Human Retroviruses: Principles of Replication and Pathogenesis.
(): World Scientific Publishing; 2010. p. 307-345 [Book Chapter]
13)  Chung NP, Breun SK, Bashirova A, Baumann JG, Martin TD, Karamchandani JM, Rausch JW, Le Grice SF, Wu L, Carrington M, Kewalramani VN.
HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).
J. Biol. Chem. 285: 2100-12, 2010.
14)  Götte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF.
Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.
Biochim. Biophys. Acta. 1804: 1202-12, 2010.
15)  Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR, Bermingham A, Beutler JA, Liu S, Zhuang X, Le Grice SF.
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.
Antimicrob. Agents Chemother. 54: 3913-21, 2010.
16)  Chung S, Rausch J, Le Grice S.
Targeting HIV-1 reverse transcriptase: A coat with many pockets. In: Innovations in Pharmaceutical Technology. Volume 31.
.: .; 2009. p. 48-51 [Book Chapter]
17)  Beilhartz GL, Wendeler M, Baichoo N, Rausch J, Le Grice S, Götte M.
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.
J. Mol. Biol. 388: 462-74, 2009.
18)  Legiewicz M, Rausch J, Le Grice S.
SHAPE technology: A modern framework for RNA structure derivation.
Eur Pharm Rev. 3: 13-18, 2009.
19)  Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X.
Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.
Science. 322: 1092-7, 2008.
20)  Turner KB, Brinson RG, Yi-Brunozzi HY, Rausch JW, Miller JT, Le Grice SF, Marino JP, Fabris D.
Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands.
Nucleic Acids Res. 36: 2799-810, 2008.
21)  Rausch JW, Le Grice SF.
Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.
Curr. HIV Res. 5: 11-22, 2007.
22)  Rausch JW, Le Grice SF.
Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.
Nucleic Acids Res. 35: 256-68, 2007.
23)  Rausch JW, Le Grice SF.
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.
Int. J. Biochem. Cell Biol. 36: 1752-66, 2004.
24)  Dash C, Rausch JW, Le Grice SF.
Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.
Nucleic Acids Res. 32: 1539-47, 2004.
25)  Rausch JW, Qu J, Yi-Brunozzi HY, Kool ET, Le Grice SF.
Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection.
Proc. Natl. Acad. Sci. U.S.A. 100: 11279-84, 2003.
26)  Rausch JW, Lener D, Miller JT, Julias JG, Hughes SH, Le Grice SF.
Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.
Biochemistry. 41: 4856-65, 2002.
27)  Cristofaro JV, Rausch JW, Le Grice SF, DeStefano JJ.
Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.
Biochemistry. 41: 10968-75, 2002.
28)  Miller JT, Rausch JW, Le Grice SF.
Evaluation of retroviral ribonuclease H activity.
Methods Mol. Biol. 160: 335-54, 2001.
29)  Gorshkova II, Rausch JW, Le Grice SF, Crouch RJ.
HIV-1 reverse transcriptase interaction with model RNA-DNA duplexes.
Anal. Biochem. 291: 198-206, 2001.
30)  Rausch JW, Grice MK, Henrietta M, Miller JT, Le Grice SF.
Interaction of p55 reverse transcriptase from the Saccharomyces cerevisiae retrotransposon Ty3 with conformationally distinct nucleic acid duplexes.
J. Biol. Chem. 275: 13879-87, 2000.
31)  Cowan JA, Ohyama T, Howard K, Rausch JW, Cowan SM, Le Grice SF.
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry.
J. Biol. Inorg. Chem. 5: 67-74, 2000.
32)  Rausch JW, Sathyanarayana BK, Bona MK, Le Grice SF.
Probing contacts between the ribonuclease H domain of HIV-1 reverse transcriptase and nucleic acid by site-specific photocross-linking.
J. Biol. Chem. 275: 16015-22, 2000.
33)  Stetor SR, Rausch JW, Guo MJ, Burnham JP, Boone LR, Waring MJ, Le Grice SF.
Characterization of (+) strand initiation and termination sequences located at the center of the equine infectious anemia virus genome.
Biochemistry. 38: 3656-67, 1999.
34)  Rausch JW, Le Grice SF.
Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase.
J. Biol. Chem. 272: 8602-10, 1997.
35)  Arts EJ, Stetor SR, Li X, Rausch JW, Howard KJ, Ehresmann B, North TW, Wöhrl BM, Goody RS, Wainberg MA, Grice SF.
Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs: implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.
Proc. Natl. Acad. Sci. U.S.A. 93: 10063-8, 1996.
36)  Rausch JW, Arts EJ, Wöhrl BM, Le Grice SF.
Involvement of C-terminal structural elements of equine infectious anemia virus reverse transcriptase in DNA polymerase and ribonuclease H activities.
J. Mol. Biol. 257: 500-11, 1996.
37)  Cirino NM, Cameron CE, Smith JS, Rausch JW, Roth MJ, Benkovic SJ, Le Grice SF.
Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase.
Biochemistry. 34: 9936-43, 1995.
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This page was last updated on 7/7/2014.