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Our Science – Chen Website

Jianbo Chen, Ph.D.

Selected Publications

1)  Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis.
Proc. Natl. Acad. Sci. U.S.A. 106: 13535-40, 2009.
[Journal]
2)  Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor.
J. Virol. 79: 4140-9, 2005.
[Journal]
3)  Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways.
Proc. Natl. Acad. Sci. U.S.A. 101: 632-7, 2004.
[Journal]
4)  Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids.
Mol. Cell. 9: 505-14, 2002.
[Journal]
5)  Chen J, Ahlquist P.
Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a.
J. Virol. 74: 4310-8, 2000.
[Journal]
6)  Chen J, Nikolaitchik O, Dilley K, Hu W.
Freed E, eds.
Packaging of the HIV-1 RNA genome. In: Advances in HIV-1 Assembly and Release.
Switzerland: Springer International Publishing; 2013. p. 55-73 [Book Chapter]
7)  Hatch SC, Sardo L, Chen J, Burdick R, Gorelick R, Fivash MJ, Pathak VK, Hu WS.
Gag-Dependent Enrichment of HIV-1 RNA near the Uropod Membrane of Polarized T Cells.
J. Virol. 87: 11912-11915, 2013.
[Journal]
8)  Dilley KA, Ni N, Nikolaitchik OA, Chen J, Galli A, Hu WS.
Determining the frequency and mechanisms of HIV-1 and HIV-2 RNA copackaging by single-virion analysis.
J. Virol. 85: 10499-508, 2011.
[Journal]
9)  Josefsson L, King MS, Makitalo B, Brännström J, Shao W, Maldarelli F, Kearney MF, Hu WS, Chen J, Gaines H, Mellors JW, Albert J, Coffin JM, Palmer SE.
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Proc. Natl. Acad. Sci. U.S.A. 108: 11199-204, 2011.
[Journal]
10)  Ni N, Nikolaitchik OA, Dilley KA, Chen J, Galli A, Fu W, Prasad VV, Ptak RG, Pathak VK, Hu WS.
Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners.
J. Virol. 85: 7603-12, 2011.
[Journal]
11)  Hussein IT, Ni N, Galli A, Chen J, Moore MD, Hu WS.
Delineation of the preferences and requirements of the human immunodeficiency virus type 1 dimerization initiation signal by using an in vivo cell-based selection approach.
J. Virol. 84: 6866-75, 2010.
[Journal]
12)  Burdick R, Smith JL, Chaipan C, Friew Y, Chen J, Venkatachari NJ, Delviks-Frankenberry KA, Hu WS, Pathak VK.
P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages.
J. Virol. 84: 10241-53, 2010.
[Journal]
13)  Moore MD, Nikolaitchik OA, Chen J, Hammarskjöld ML, Rekosh D, Hu WS.
Probing the HIV-1 genomic RNA trafficking pathway and dimerization by genetic recombination and single virion analyses.
PLoS Pathog. 5: e1000627, 2009.
[Journal]
14)  Chen J, Pathak VK, Peng W, Hu WS.
Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses.
J. Virol. 82: 8253-61, 2008.
[Journal]
15)  Motomura K, Chen J, Hu WS.
Genetic recombination between human immunodeficiency virus type 1 (HIV-1) and HIV-2, two distinct human lentiviruses.
J. Virol. 82: 1923-33, 2008.
[Journal]
16)  Chin MP, Lee SK, Chen J, Nikolaitchik OA, Powell DA, Fivash MJ, Hu WS.
Long-range recombination gradient between HIV-1 subtypes B and C variants caused by sequence differences in the dimerization initiation signal region.
J. Mol. Biol. 377: 1324-33, 2008.
[Journal]
17)  Thomas DC, Voronin YA, Nikolenko GN, Chen J, Hu WS, Pathak VK.
Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis.
J. Virol. 81: 4798-807, 2007.
[Journal]
18)  Moore MD, Fu W, Nikolaitchik O, Chen J, Ptak RG, Hu WS.
Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination.
J. Virol. 81: 4002-11, 2007.
[Journal]
19)  Chin MP, Chen J, Nikolaitchik OA, Hu WS.
Molecular determinants of HIV-1 intersubtype recombination potential.
Virology. 363: 437-46, 2007.
[Journal]
20)  Fu W, Prasad VV, Chen J, Nikolaitchik O, Hu WS.
Molecular mechanisms of simian immunodeficiency virus SIV(agm) RNA encapsidation.
Virology. 363: 210-9, 2007.
[Journal]
21)  Xu H, Chertova E, Chen J, Ott DE, Roser JD, Hu WS, Pathak VK.
Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions.
Virology. 360: 247-56, 2007.
[Journal]
22)  Chen J, Powell D, Hu WS.
High frequency of genetic recombination is a common feature of primate lentivirus replication.
J. Virol. 80: 9651-8, 2006.
[Journal]
23)  Chen J, Rhodes TD, Hu WS.
Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells.
J. Virol. 79: 9337-40, 2005.
[Journal]
24)  Rhodes TD, Nikolaitchik O, Chen J, Powell D, Hu WS.
Genetic recombination of human immunodeficiency virus type 1 in one round of viral replication: effects of genetic distance, target cells, accessory genes, and lack of high negative interference in crossover events.
J. Virol. 79: 1666-77, 2005.
[Journal]
25)  Chin MP, Rhodes TD, Chen J, Fu W, Hu WS.
Identification of a major restriction in HIV-1 intersubtype recombination.
Proc. Natl. Acad. Sci. U.S.A. 102: 9002-7, 2005.
[Journal]
26)  Ahlquist P, Schwartz M, Chen J, Kushner D, Hao L, Dye BT.
Viral and host determinants of RNA virus vector replication and expression.
Vaccine. 23: 1784-7, 2005.
[Journal]
27)  Schwartz M, Chen J, Lee WM, Janda M, Ahlquist P.
Alternate, virus-induced membrane rearrangements support positive-strand RNA virus genome replication.
Proc. Natl. Acad. Sci. U.S.A. 101: 11263-8, 2004.
[Journal]
28)  Chen J, Noueiry A, Ahlquist P.
An alternate pathway for recruiting template RNA to the brome mosaic virus RNA replication complex.
J. Virol. 77: 2568-77, 2003.
[Journal]
29)  Noueiry AO, Diez J, Falk SP, Chen J, Ahlquist P.
Yeast Lsm1p-7p/Pat1p deadenylation-dependent mRNA-decapping factors are required for brome mosaic virus genomic RNA translation.
Mol. Cell. Biol. 23: 4094-106, 2003.
[Journal]
30)  Chen J, Noueiry A, Ahlquist P.
Brome mosaic virus Protein 1a recruits viral RNA2 to RNA replication through a 5' proximal RNA2 signal.
J. Virol. 75: 3207-19, 2001.
[Journal]
31)  den Boon JA, Chen J, Ahlquist P.
Identification of sequences in Brome mosaic virus replicase protein 1a that mediate association with endoplasmic reticulum membranes.
J. Virol. 75: 12370-81, 2001.
[Journal]
32)  Noueiry AO, Chen J, Ahlquist P.
A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA.
Proc. Natl. Acad. Sci. U.S.A. 97: 12985-90, 2000.
[Journal]
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This page was last updated on 7/7/2014.