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Our Science – Datta Website

Siddhartha A.K. Datta, Ph.D.

Selected Publications

1)  Munro JB, Nath A, Färber M, Datta SA, Rein A, Rhoades E, Mothes W.
A Conformational Transition Observed in Single HIV-1 Gag Molecules during In Vitro Assembly of Virus-Like Particles.
J. Virol. 88: 3577-85, 2014.
2)  Rein A, Datta SA, Jones CP, Musier-Forsyth K.
Diverse interactions of retroviral Gag proteins with RNAs.
Trends Biochem. Sci. 36: 373-80, 2011.
Full Text Article. [Journal]
3)  Datta SA, Heinrich F, Raghunandan S, Krueger S, Curtis JE, Rein A, Nanda H.
HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid.
J. Mol. Biol. 406: 205-14, 2011.
4)  Datta SA, Temeselew LG, Crist RM, Soheilian F, Kamata A, Mirro J, Harvin D, Nagashima K, Cachau RE, Rein A.
On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch?.
J. Virol. 85: 4111-21, 2011.
5)  Datta SA, Zuo X, Clark PK, Campbell SJ, Wang YX, Rein A.
Solution properties of murine leukemia virus gag protein: differences from HIV-1 gag.
J. Virol. 85: 12733-41, 2011.
6)  Goicochea NL, Datta SA, Ayaluru M, Kao C, Rein A, Dragnea B.
Structure and stoichiometry of template-directed recombinant HIV-1 Gag particles.
J. Mol. Biol. 410: 667-80, 2011.
7)  Jones CP, Datta SA, Rein A, Rouzina I, Musier-Forsyth K.
Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activityI via inositol phosphate binding.
J. Virol. 85: 1594-1603, 2011.
Full Text Article. [Journal]
8)  Ramalingam D, Duclair S, Datta SA, Ellington A, Rein A, Prasad VR.
RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production.
J. Virol. 85: 305-14, 2011.
Full Text Article. [Journal]
9)  Gherghe C, Lombo T, Leonard CW, Datta SA, Bess JW, Gorelick RJ, Rein A, Weeks KM.
Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.
Proc. Natl. Acad. Sci. U.S.A. 107: 19248-53, 2010.
Full Text Article. [Journal]
10)  Nanda H, Datta SA, Heinrich F, Lösche M, Rein A, Krueger S, Curtis JE.
Electrostatic interactions and binding orientation of HIV-1 matrix studied by neutron reflectivity.
Biophys. J. 99: 2516-24, 2010.
Full Text Article. [Journal]
11)  Wu T, Datta SA, Mitra M, Gorelick RJ, Rein A, Levin JG.
Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: Biological implications.
Virology. 405: 556-567, 2010.
Full Text Article. [Journal]
12)  Crist RM, Datta SA, Stephen AG, Soheilian F, Mirro J, Fisher RJ, Nagashima K, Rein A.
Assembly properties of human immunodeficiency virus type 1 Gag-leucine zipper chimeras: implications for retrovirus assembly.
J. Virol. 83: 2216-25, 2009.
Full Text Article. [Journal]
13)  Datta SA, Rein A.
Preparation of recombinant HIV-1 gag protein and assembly of virus-like particles in vitro.
Methods Mol. Biol. 485: 197-208, 2009.
Full Text Article. [Journal]
14)  Datta SA, Curtis JE, Ratcliff W, Clark PK, Crist RM, Lebowitz J, Krueger S, Rein A.
Conformation of the HIV-1 Gag protein in solution.
J. Mol. Biol. 365: 812-24, 2007.
Full Text Article. [Journal]
15)  Datta SA, Zhao Z, Clark PK, Tarasov S, Alexandratos JN, Campbell SJ, Kvaratskhelia M, Lebowitz J, Rein A.
Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch.
J. Mol. Biol. 365: 799-811, 2007.
Full Text Article. [Journal]
16)  Ricci EP, Herbreteau CH, Decimo D, Schaupp A, Datta SA, Rein A, Darlix J, Ohlmann T.
In vitro expression of the HIV-2 genomic RNA is controlled by three distinct internal ribosome entry segments that are regulated by the HIV protease and the Gag polyprotein.
RNA. 14: 1443-55, 2008.
Full Text Article. [Journal]
17)  Stephen AG, Datta SA, Worthy KM, Bindu L, Fivash MJ, Turner KB, Fabris D, Rein A, Fisher RJ.
Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.
J Biomol Tech. 18: 259-66, 2007.
Full Text Article. [Journal]
18)  Kovaleski BJ, Kennedy R, Hong MK, Datta SA, Kleiman L, Rein A, Musier-Forsyth K.
In vitro characterization of the interaction between HIV-1 Gag and human lysyl-tRNA synthetase.
J. Biol. Chem. 281: 19449-56, 2006.
Full Text Article. [Journal]
19)  Shkriabai N, Datta SA, Zhao Z, Hess S, Rein A, Kvaratskhelia M.
Interactions of HIV-1 Gag with assembly cofactors.
Biochemistry. 45: 4077-83, 2006.
Full Text Article. [Journal]
20)  Cruceanu M, Urbaneja MA, Hixson CV, Johnson DG, Datta SA, Fivash MJ, Stephen AG, Fisher RJ, Gorelick RJ, Casas-Finet JR, Rein A, Rouzina I, Williams MC.
Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins.
Nucleic Acids Res. 34: 593-605, 2006.
Full Text Article. [Journal]
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This page was last updated on 3/12/2014.