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Our Science – Ridnour Website

Lisa Ann Ridnour, Ph.D.

Selected Publications

1)  Soto-Pantoja DR, Miller TW, Pendrak ML, Degraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.
CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.
Autophagy. 8, 2012.
2)  Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA.
Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.
Cancer Res. 72: 2394-404, 2012.
3)  Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA.
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer.
Breast Cancer Res. 14: R125, 2012.
4)  Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, Harris CC.
Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease.
PLoS ONE. 7: e44156, 2012.
5)  Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA.
Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation.
PLoS ONE. 7: e44081, 2012.
6)  Ridnour L, Dhanapal S, Hoos M, Wilson J, Lee J, Cheng R, Brueggemann E, Hines H, Wilcock D, Vitek M, Wink D, Colton C.
Nitric Oxide-Mediated Regulation of β-Amyloid Clearance via Alterations of MMP-9/TIMP-1.
J. Neurochem. 2012.
7)  Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA.
S-Nitrosylation of EGFR and Src Activates an Oncogenic Signaling Network in Human Basal-Like Breast Cancer.
Mol. Cancer Res. 10: 1203-15, 2012.
8)  Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA.
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence.
J Neuroinflammation. 8: 115, 2011.
9)  Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA.
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Trends Pharmacol. Sci. 32: 644-51, 2011.
10)  Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA.
Nitric oxide and redox mechanisms in the immune response.
J. Leukoc. Biol. 89: 873-91, 2011.
11)  Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S.
COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.
BMC Cancer. 10: 626, 2010.
12)  Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
Lung Cancer. 68: 154-60, 2010.
13)  Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S.
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.
J. Clin. Invest. 120: 3843-54, 2010.
14)  Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
J. Exp. Med. 207: 2455-67, 2010.
15)  Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD.
Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton.
Cell Stress Chaperones. 15: 165-81, 2010.
16)  Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S.
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.
Clin. Cancer Res. 15: 4165-73, 2009.
17)  Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM, Fukuto JM, Wink DA.
Comparing the chemical biology of NO and HNO.
Arch. Pharm. Res. 32: 1139-53, 2009.
18)  Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA.
Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.
Oncogene. 28: 3837-46, 2009.
19)  Maxhimer JB, Soto-Pantoja DR, Ridnour LA, Shih HB, Degraff WG, Tsokos M, Wink DA, Isenberg JS, Roberts DD.
Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling.
Sci Transl Med. 1: 3ra7, 2009.
20)  Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM, Paolocci N, Wink DA.
The emergence of nitroxyl (HNO) as a pharmacological agent.
Biochim. Biophys. Acta. 1787: 835-40, 2009.
21)  Dai S, Jia Y, Wu SL, Isenberg JS, Ridnour LA, Bandle RW, Wink DA, Roberts DD, Karger BL.
Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin.
J. Proteome Res. 7: 4384-95, 2008.
22)  Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA.
Molecular mechanisms for discrete nitric oxide levels in cancer.
Nitric Oxide. 19: 73-6, 2008.
23)  Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA.
The chemical biology of nitric oxide: implications in cellular signaling.
Free Radic. Biol. Med. 45: 18-31, 2008.
24)  Wink DA, Ridnour LA, Hussain SP, Harris CC.
The reemergence of nitric oxide and cancer.
Nitric Oxide. 19: 65-7, 2008.
25)  Isenberg JS, Hyodo F, Ridnour LA, Shannon CS, Wink DA, Krishna MC, Roberts DD.
Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.
Neoplasia. 10: 886-96, 2008.
26)  Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, Roberts DD.
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells.
Cancer Res. 68: 7090-9, 2008.
27)  Isenberg JS, Maxhimer JB, Hyodo F, Pendrak ML, Ridnour LA, DeGraff WG, Tsokos M, Wink DA, Roberts DD.
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.
Am. J. Pathol. 173: 1100-12, 2008.
28)  Brown KE, Meleah Mathahs M, Broadhurst KA, Coleman MC, Ridnour LA, Schmidt WN, Spitz DR.
Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state?.
Free Radic. Biol. Med. 42: 228-35, 2007.
29)  Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD.
Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.
Br. J. Pharmacol. 151: 63-72, 2007.
30)  Roberts DD, Isenberg JS, Ridnour LA, Wink DA.
Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis.
Clin. Cancer Res. 13: 795-8, 2007.
31)  Ridnour LA, Windhausen AN, Isenberg JS, Yeung N, Thomas DD, Vitek MP, Roberts DD, Wink DA.
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.
Proc. Natl. Acad. Sci. U.S.A. 104: 16898-903, 2007.
32)  Thomas DD, Espey MG, Pociask DA, Ridnour LA, Donzelli S, Wink DA.
Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite.
Cancer Res. 66: 11600-4, 2006.
33)  Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD.
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1.
J. Biol. Chem. 281: 26069-80, 2006.
34)  Donzelli S, Espey MG, Thomas DD, Mancardi D, Tocchetti CG, Ridnour LA, Paolocci N, King SB, Miranda KM, Lazzarino G, Fukuto JM, Wink DA.
Discriminating formation of HNO from other reactive nitrogen oxide species.
Free Radic. Biol. Med. 40: 1056-66, 2006.
35)  Isenberg JS, Ridnour LA, Thomas DD, Wink DA, Roberts DD, Espey MG.
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients.
Free Radic. Biol. Med. 40: 1028-33, 2006.
36)  Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, Wink DA.
Superoxide fluxes limit nitric oxide-induced signaling.
J. Biol. Chem. 281: 25984-93, 2006.
37)  Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB, Lazzarino G, Miranda KM, Roberts DD, Feelisch M, Wink DA.
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.
Antioxid. Redox Signal. 8: 1363-71, 2006.
38)  Ridnour LA, Thomas DD, Donzelli S, Espey MG, Roberts DD, Wink DA, Isenberg JS.
The biphasic nature of nitric oxide responses in tumor biology.
Antioxid. Redox Signal. 8: 1329-37, 2006.
39)  Miranda KM, Katori T, Torres de Holding CL, Thomas L, Ridnour LA, McLendon WJ, Cologna SM, Dutton AS, Champion HC, Mancardi D, Tocchetti CG, Saavedra JE, Keefer LK, Houk KN, Fukuto JM, Kass DA, Paolocci N, Wink DA.
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
J. Med. Chem. 48: 8220-8, 2005.
40)  Miranda KM, Dutton AS, Ridnour LA, Foreman CA, Ford E, Paolocci N, Katori T, Tocchetti CG, Mancardi D, Thomas DD, Espey MG, Houk KN, Fukuto JM, Wink DA.
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
J. Am. Chem. Soc. 127: 722-31, 2005.
41)  Isenberg JS, Ridnour LA, Espey MG, Wink DA, Roberts DD.
Nitric oxide in wound-healing.
Microsurgery. 25: 442-51, 2005.
42)  Ridnour LA, Isenberg JS, Espey MG, Thomas DD, Roberts DD, Wink DA.
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1.
Proc. Natl. Acad. Sci. U.S.A. 102: 13147-52, 2005.
43)  Ridnour LA, Sim JE, Choi J, Dickinson DA, Forman HJ, Ahmad IM, Coleman MC, Hunt CR, Goswami PC, Spitz DR.
Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.
Free Radic. Biol. Med. 38: 1361-71, 2005.
44)  Isenberg JS, Ridnour LA, Perruccio EM, Espey MG, Wink DA, Roberts DD.
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner.
Proc. Natl. Acad. Sci. U.S.A. 102: 13141-6, 2005.
45)  Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, Wink DA.
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.
Proc. Natl. Acad. Sci. U.S.A. 101: 8894-9, 2004.
46)  Mancardi D, Ridnour LA, Thomas DD, Katori T, Tocchetti CG, Espey MG, Miranda KM, Paolocci N, Wink DA.
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.
Curr. Mol. Med. 4: 723-40, 2004.
47)  Ridnour LA, Thomas DD, Mancardi D, Espey MG, Miranda KM, Paolocci N, Feelisch M, Fukuto J, Wink DA.
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
Biol. Chem. 385: 1-10, 2004.
48)  Ridnour LA, Oberley TD, Oberley LW.
Tumor suppressive effects of MnSOD overexpression may involve imbalance in peroxide generation versus peroxide removal.
Antioxid. Redox Signal. 6: 501-12, 2004.
49)  Brown KE, Dennery PA, Ridnour LA, Fimmel CJ, Kladney RD, Brunt EM, Spitz DR.
Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats.
Liver Int. 23: 232-42, 2003.
50)  Wink DA, Miranda KM, Katori T, Mancardi D, Thomas DD, Ridnour L, Espey MG, Feelisch M, Colton CA, Fukuto JM, Pagliaro P, Kass DA, Paolocci N.
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
Am. J. Physiol. Heart Circ. Physiol. 285: H2264-76, 2003.
51)  Henderson JP, Byun J, Williams MV, McCormick ML, Parks WC, Ridnour LA, Heinecke JW.
Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors.
Proc. Natl. Acad. Sci. U.S.A. 98: 1631-6, 2001.
52)  Ridnour LA, Sim JE, Hayward MA, Wink DA, Martin SM, Buettner GR, Spitz DR.
A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media.
Anal. Biochem. 281: 223-9, 2000.
53)  Goswami PC, Sheren J, Albee LD, Parsian A, Sim JE, Ridnour LA, Higashikubo R, Gius D, Hunt CR, Spitz DR.
Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.
J. Biol. Chem. 275: 38384-92, 2000.
54)  Lee YJ, Galoforo SS, Sim JE, Ridnour LA, Choi J, Forman HJ, Corry PM, Spitz DR.
Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line.
Free Radic. Biol. Med. 28: 575-84, 2000.
55)  Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ.
Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?.
Ann. N. Y. Acad. Sci. 899: 349-62, 2000.
56)  Ridnour LA, Winters RA, Ercal N, Spitz DR.
Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives.
Meth. Enzymol. 299: 258-67, 1999.
57)  Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ.
Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells.
Free Radic. Biol. Med. 26: 419-30, 1999.
58)  Brown KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR.
Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload.
Free Radic. Biol. Med. 24: 545-55, 1998.
59)  Goswami PC, Albee LD, Spitz DR, Ridnour LA.
A polymerase chain reaction assay for simultaneous detection and quantitation of proto-oncogene and GAPD mRNAs in different cell growth rates.
Cell Prolif. 30: 271-82, 1997.
60)  Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD.
Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase.
Oncogene. 10: 1989-2000, 1995.
61)  Czaja MJ, Schilsky ML, Xu Y, Schmiedeberg P, Compton A, Ridnour L, Oberley LW.
Induction of MnSOD gene expression in a hepatic model of TNF-alpha toxicity does not result in increased protein.
Am. J. Physiol. 266: G737-44, 1994.
62)  Church SL, Grant JW, Ridnour LA, Oberley LW, Swanson PE, Meltzer PS, Trent JM.
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.
Proc. Natl. Acad. Sci. U.S.A. 90: 3113-7, 1993.
63)  Bertolatus JA, Klinzman D, Bronsema DA, Ridnour L, Oberley LW.
Evaluation of the role of reactive oxygen species in doxorubicin hydrochloride nephrosis.
J. Lab. Clin. Med. 118: 435-45, 1991.
64)  Oberley LW, Ridnour LA, Sierra-Rivera E, Oberley TD, Guernsey DL.
Superoxide dismutase activities of differentiating clones from an immortal cell line.
J. Cell. Physiol. 138: 50-60, 1989.
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This page was last updated on 10/25/2012.